目的:从中国医疗卫生体系角度出发,评价阿得贝利单抗联合化疗与安慰剂在一线治疗广泛期小细胞肺癌的成本-效果。方法:根据一项Ⅲ期临床试验数据(CAPSTONE-1)建立分区生存模型,以99%的患者死亡为终点,研究时限为5.4年。计算增量成本-效果...目的:从中国医疗卫生体系角度出发,评价阿得贝利单抗联合化疗与安慰剂在一线治疗广泛期小细胞肺癌的成本-效果。方法:根据一项Ⅲ期临床试验数据(CAPSTONE-1)建立分区生存模型,以99%的患者死亡为终点,研究时限为5.4年。计算增量成本-效果比(incremental cost-effectiveness ratio,ICER),并对主要参数进行单因素敏感性分析和概率敏感性分析。结果:基础分析结果显示,阿得贝利联合化疗组比安慰剂联合化疗组多了0.29个质量调整生命年(quality-adjusting life years,QALYs),而成本增加了206494.10元,ICER为703030.60元/QALY。单因素敏感性分析结果显示阿得贝利单抗成本、无进展生存期状态的效用值以及临终关怀成本对ICER影响较大。概率敏感性分析结果显示模型稳健。结论:在2022年中国3倍人均国内生产总值的意愿支付阈值下,阿得贝利单抗联合化疗一线治疗广泛期小细胞肺癌不具有经济性。展开更多
人们都知道悉尼夺得了2000年奥运会的举办权,但未必了解平时每年有多少次国际性体育大赛在澳大利亚举行。赫赫有名的维多利亚澳式橄榄球联赛(Victorian Football Lcague,VFL)、举世瞩目的墨尔本职业板球赛(MCG)、扣人心弦的阿得雷德欧...人们都知道悉尼夺得了2000年奥运会的举办权,但未必了解平时每年有多少次国际性体育大赛在澳大利亚举行。赫赫有名的维多利亚澳式橄榄球联赛(Victorian Football Lcague,VFL)、举世瞩目的墨尔本职业板球赛(MCG)、扣人心弦的阿得雷德欧洲汽车大奖赛(Formula l Grand Prix)、名闻遐迩的墨尔本杯赛马节(Melbourne Cup)等众多的体育赛事都令人心弛神往。澳大利亚是世界上最小的大陆,最大的岛屿。展开更多
Motion event typology predicts that languages can be divided into either satellite-framed, verb-framed or serial-framed languages. However, an increasing number of studies show that languages within the same type pred...Motion event typology predicts that languages can be divided into either satellite-framed, verb-framed or serial-framed languages. However, an increasing number of studies show that languages within the same type predispose their speakers to describe motion events differently. Based on the narrative behavior of 15 native speakers, we provide evidence that suggests Tunisian Arabic （TA） is an untypical verb-framed language. One the one hand, TA conflates motion and path meanings in the main verb, and native speakers adhere to the boundary-crossing constraint. On the other hand, the availability of a rich manner verb lexicon combined with the availability of mono-verbal clauses ready to be coordinated asyndetically, encourages TA speakers to attend to the manner of motion more often than reported for a typical verb-framed language （e.g., Spanish）. Based on these fmdings, we conclude that predictions based on motion event typology are best considered as guidelines, and not as an accurate reflection of how motion meanings may be lexicalized and expressed in individual languages展开更多
文摘目的:从中国医疗卫生体系角度出发,评价阿得贝利单抗联合化疗与安慰剂在一线治疗广泛期小细胞肺癌的成本-效果。方法:根据一项Ⅲ期临床试验数据(CAPSTONE-1)建立分区生存模型,以99%的患者死亡为终点,研究时限为5.4年。计算增量成本-效果比(incremental cost-effectiveness ratio,ICER),并对主要参数进行单因素敏感性分析和概率敏感性分析。结果:基础分析结果显示,阿得贝利联合化疗组比安慰剂联合化疗组多了0.29个质量调整生命年(quality-adjusting life years,QALYs),而成本增加了206494.10元,ICER为703030.60元/QALY。单因素敏感性分析结果显示阿得贝利单抗成本、无进展生存期状态的效用值以及临终关怀成本对ICER影响较大。概率敏感性分析结果显示模型稳健。结论:在2022年中国3倍人均国内生产总值的意愿支付阈值下,阿得贝利单抗联合化疗一线治疗广泛期小细胞肺癌不具有经济性。
文摘人们都知道悉尼夺得了2000年奥运会的举办权,但未必了解平时每年有多少次国际性体育大赛在澳大利亚举行。赫赫有名的维多利亚澳式橄榄球联赛(Victorian Football Lcague,VFL)、举世瞩目的墨尔本职业板球赛(MCG)、扣人心弦的阿得雷德欧洲汽车大奖赛(Formula l Grand Prix)、名闻遐迩的墨尔本杯赛马节(Melbourne Cup)等众多的体育赛事都令人心弛神往。澳大利亚是世界上最小的大陆,最大的岛屿。
文摘Motion event typology predicts that languages can be divided into either satellite-framed, verb-framed or serial-framed languages. However, an increasing number of studies show that languages within the same type predispose their speakers to describe motion events differently. Based on the narrative behavior of 15 native speakers, we provide evidence that suggests Tunisian Arabic （TA） is an untypical verb-framed language. One the one hand, TA conflates motion and path meanings in the main verb, and native speakers adhere to the boundary-crossing constraint. On the other hand, the availability of a rich manner verb lexicon combined with the availability of mono-verbal clauses ready to be coordinated asyndetically, encourages TA speakers to attend to the manner of motion more often than reported for a typical verb-framed language （e.g., Spanish）. Based on these fmdings, we conclude that predictions based on motion event typology are best considered as guidelines, and not as an accurate reflection of how motion meanings may be lexicalized and expressed in individual languages
