Two new furostanol glycosides, aspacochinosides L （1） and M （2）, were isolated from the roots of Asparagus cochinchinensis （Lour.） Merr. Their structures were determined by chemical methods and NMR spectral anal...Two new furostanol glycosides, aspacochinosides L （1） and M （2）, were isolated from the roots of Asparagus cochinchinensis （Lour.） Merr. Their structures were determined by chemical methods and NMR spectral analysis, including extensive 1D and 2D NMR experiments. Compounds 1 and 2 were investigated for their anti-neuroinflammatory activity in LPS-induced BV-2 cells. Compound 2 showed moderate inhibitory effect on NO production in LPS-induced BV-2 microglial cells with IC 50 value of 32.26 μM.展开更多
基金supported by National Key Technology R&D Program"New Drug Innovation"of China(Grant No.2012ZX09301002-002-002and2012ZX09304-005)
文摘Two new furostanol glycosides, aspacochinosides L （1） and M （2）, were isolated from the roots of Asparagus cochinchinensis （Lour.） Merr. Their structures were determined by chemical methods and NMR spectral analysis, including extensive 1D and 2D NMR experiments. Compounds 1 and 2 were investigated for their anti-neuroinflammatory activity in LPS-induced BV-2 cells. Compound 2 showed moderate inhibitory effect on NO production in LPS-induced BV-2 microglial cells with IC 50 value of 32.26 μM.
