阿苷洛韦治疗流行性腮腺炎临床疗效观察(附30例报告)

流行性腮腺炎每年的发病率都较高,好发于幼托儿童及在校小学生。为了缩短流行性腮腺炎病程、减少并发症,我院近来运用阿苷洛韦(无环鸟苷)治疗流行性腮腺炎,收到了较好的疗效,现报告如下。临床资料 1 病例所用病例系1993年1月以来所收治的住院患者,随机配对各30例,分别予以施阿苷洛韦(治疗组)和病毒唑(对照组)治疗,

阿苷洛韦针与三氮唑核苷针对比治疗带状疱疹的疗效观察

用阿苷洛韦针与三氮唑核苷针治疗带状疱疹.结果:阿苷洛韦组有效率为95.8%,三氮唑核苷组有效率为87.5%.说明前者为目前临床治疗疱疹病毒感染的首选药物.

用反相高效液相色谱法同时测定血中地苷洛韦和阿苷洛韦的浓度

目的：为了满足地苷洛韦（脱氧无环鸟苷，ＤＣＶ）药代动力学研究和血药浓度监测的需要，建立了能够同时测定血中ＤＣＶ和阿苷洛韦（无环鸟苷，ＡＣＶ）的反相高效液相色谱（ＨＰＬＣ）分离测定方法。方法：血浆经离心式超滤器离心除蛋白后，取超滤液直接进行ＨＰＬＣ分析。色谱条件如下：ＳｐｈｅｒｉｓｏｒｂＣ１８分析柱；甲醇水（１５８５，体积比）作为流动相，流速０．７ｍｌ／ｍｉｎ；可编程紫外检测器，波长：ＤＣＶ３０５ｎｍ，ＡＣＶ２０５ｎｍ；外标法定量。结果：血中ＤＣＶ和ＡＣＶ的最低检出浓度分别是０．１４和０．０８μｇ／ｍｌ；在１．０～２０μｇ／ｍｌ浓度范围内，血中ＤＣＶ和ＡＣＶ测定的平均回收率分别是（９９．２±１０．４）％和（１０９．２±２．５）％，重复测定变异系数分别是２．７％～１０．７％和０．２％～４．０％。结论：建立了同时测定血中ＤＣＶ和ＡＣＶ浓度的ＨＰＬＣ分离测定方法。该法灵敏、快速、准确、复演性好。

生脉注射液联合阿昔洛韦治疗带状疱疹的疗效观察

生脉注射液与阿昔洛韦合用治疗带状疱疹,取得良好疗效。

阿艹甘洛韦片治疗带状疱疹临床观察

阿艹甘洛韦片治疗带状疱疹临床观察广东省深圳市南山人民医院皮肤科（５１８０５２）徐大云宦秉瑜带状疱疹是皮肤科常见疾病。是由水痘一带状疱疹病毒感染所致。临床上往往由于机体免疫功能下降导致带状疱疹发病主要原因之一。尽管目前有较多的治疗方法：如使用干扰素、聚...

无环鸟苷与聚肌胞联合治疗口腔单纯疱疹的疗效

目的：了解无环鸟苷与聚肌胞联合治疗口腔单纯疱疹感染的效果。方法：以无环鸟苷为抗病毒局部涂擦药物，配以肌注聚肌胞免疫增强剂为全身用药，并以素高捷疗口腔膏与肌注ＶｉｔＢ１２为对照组。结果：实验组与对照组相比，有显著性差异，（χ２＝１０．７１，Ｐ＜０．０１），治愈天数缩短（Ｐ＜０．０１），全身症状轻于对照组，复发时间也相应延长。

病毒性皮肤病

9835615 阿苷洛韦治疗寻常疱疹的经验[俄,英摘]/∥.-1997,75(7).-56～59 友谊医 9835616 尖锐湿疣的门诊治疗[日]/泷泽宪∥临妇产.-1997,51(2).-148～151 冀医情 9835617 色素性疣:DNA技术学对人乳头(状)瘤病毒毒基因型的鉴定[日]/本多章乃∥皮科临.-1997,39(5).-719～724

Effects of herpes simplex virus thymidine kinase/acyclovir system on growth of human pulmonary adenocarcinoma A549 cell line in vitro and in vivo

Objective: To observe the effect of anciclovir (ACV) treatment on tumors induced by inoculation of TK gene-transfected human pulmonary adenocarcinoma A549 cells in nude mice. Methods: A recombinant plasmid containing TK gene was constructed and transfected into A549 cells by electroporation. The sensitivity of the transgenic cells (A549-TK) to ACV was examined by MTT assay in vitro and for in vivo observation, inoculation of A549-TK and A-549 cells into nude mice was separately performed to induce tumor growth, the response of which to ACV treatment was observed, and the tumor tissues were pathologically examined. Results: A recombinant plasmid containing TK gene was successfully constructed and transfected into A549 cells. The sensitivity of A549-TK cells to ACV was 43 times higher than that of A549 cells. The tumors induced by A549-TK cells showed no significant increase in size after ACV treatment (P>0. 05) , and light microscopy revealed local tissue necrosis, karyoklasis, and nuclei disappearance. Conclusion: A549-TK cells acquires sensitivity to ACV both in vitro and in vivo, and ACV can inhibit the growth of tumors induced by A549-TK cell inoculation in nude mice.