Despite its high prevalence, nonulcer dyspepsia is still difficult to study, d ue to the lack of adequate tools to measure significant outcomes. The objective of this study was to develop and validate a symptom-focuse...Despite its high prevalence, nonulcer dyspepsia is still difficult to study, d ue to the lack of adequate tools to measure significant outcomes. The objective of this study was to develop and validate a symptom-focused, disease- -specific questionnaire to evaluate patients with nonulcer dyspepsia. For tha t, the questionnaire was carefully written following widely accepted terminology , so as to facilitate translation and validation in other languages and cultures . The questionnaire was developed using Rome I terminology for symptoms, which w ere evaluated according to their intensity, duration, and frequency when applica ble.Thirty-one patients with nonulcer dyspepsia, as well as 31 sex and age-mat ched volunteers without digestive problems were used to assess the internal cons istency, reproducibility,responsiveness, content validity, and discriminant vali dity of the questionnaire. Another 31 functional dyspeptic patients were enrolle d for assessment of criterion validity. Cronbach’s αcoefficient was 0.82. The intraclass correlation coefficient for the scores obtained 7 days apart was 0.86 . The mean score obtained after 3 months of treatment was 16.4, vs. 23.03 at bas eline (P = 0.001). Two blinded gastroenterologists agreed that the questionnaire adequately evaluated nonulcer dyspepsia.The median symptoms score for controls was 0, vs. 22.5 for dyspeptic patients (P = 0.001). An inverse correlation was o bserved between quality of life and dyspeptic symptoms (R=-0.28, P = 0.026). Th e proposed questionnaire has high degrees of both reproducibility and responsive ness. As this questionnaire was based on Rome I International Consensus terminol ogy, it is expected that it will be easy to translate and validate.展开更多
他的名字叫Ronaldo de Assis Moreira,大家都喜欢叫他罗纳尔迪尼奥。他拥有阳光般灿烂的微笑,对生活和竞技的巨大热情以及出神入化的卓越球技。大家很早就对他精湛的室内足球球技有所耳闻。早年,在巴西阿雷格里港的大街上,海滩边,以及...他的名字叫Ronaldo de Assis Moreira,大家都喜欢叫他罗纳尔迪尼奥。他拥有阳光般灿烂的微笑,对生活和竞技的巨大热情以及出神入化的卓越球技。大家很早就对他精湛的室内足球球技有所耳闻。早年,在巴西阿雷格里港的大街上,海滩边,以及在随家乡球队格雷米奥队征战期间,罗纳尔迪尼奥表现出超强的控球能力,精准的传球和娴熟细腻的脚下功夫,令人大为称道。随后,在世人的注目下.他从巴西走向了世界,成为巴西队赢得2002年世界杯冠军的功臣,此后又连获2004年和2005年"世界足球先生"殊荣,并帮助巴塞罗那队在欧洲冠军杯中一举夺魁。他是一个传奇,这是毋庸置疑的。展开更多
文摘Despite its high prevalence, nonulcer dyspepsia is still difficult to study, d ue to the lack of adequate tools to measure significant outcomes. The objective of this study was to develop and validate a symptom-focused, disease- -specific questionnaire to evaluate patients with nonulcer dyspepsia. For tha t, the questionnaire was carefully written following widely accepted terminology , so as to facilitate translation and validation in other languages and cultures . The questionnaire was developed using Rome I terminology for symptoms, which w ere evaluated according to their intensity, duration, and frequency when applica ble.Thirty-one patients with nonulcer dyspepsia, as well as 31 sex and age-mat ched volunteers without digestive problems were used to assess the internal cons istency, reproducibility,responsiveness, content validity, and discriminant vali dity of the questionnaire. Another 31 functional dyspeptic patients were enrolle d for assessment of criterion validity. Cronbach’s αcoefficient was 0.82. The intraclass correlation coefficient for the scores obtained 7 days apart was 0.86 . The mean score obtained after 3 months of treatment was 16.4, vs. 23.03 at bas eline (P = 0.001). Two blinded gastroenterologists agreed that the questionnaire adequately evaluated nonulcer dyspepsia.The median symptoms score for controls was 0, vs. 22.5 for dyspeptic patients (P = 0.001). An inverse correlation was o bserved between quality of life and dyspeptic symptoms (R=-0.28, P = 0.026). Th e proposed questionnaire has high degrees of both reproducibility and responsive ness. As this questionnaire was based on Rome I International Consensus terminol ogy, it is expected that it will be easy to translate and validate.
文摘他的名字叫Ronaldo de Assis Moreira,大家都喜欢叫他罗纳尔迪尼奥。他拥有阳光般灿烂的微笑,对生活和竞技的巨大热情以及出神入化的卓越球技。大家很早就对他精湛的室内足球球技有所耳闻。早年,在巴西阿雷格里港的大街上,海滩边,以及在随家乡球队格雷米奥队征战期间,罗纳尔迪尼奥表现出超强的控球能力,精准的传球和娴熟细腻的脚下功夫,令人大为称道。随后,在世人的注目下.他从巴西走向了世界,成为巴西队赢得2002年世界杯冠军的功臣,此后又连获2004年和2005年"世界足球先生"殊荣,并帮助巴塞罗那队在欧洲冠军杯中一举夺魁。他是一个传奇,这是毋庸置疑的。
