920333 Measurement of epidermal growthfactor on the stimulation of DNA synthesis inliver cells by flow cytometry.CHEN Tuxing (陈图兴),et al.Nanjing Med Coll.(210029) Chin
Objective To evaluate metabolic abnormalities in patients with mesial temporal lobe epilepsy （MTLE） with proton magnetic resonance spectroscopy （MRS） using a 3.0T MR scanner. Methods Sixty-three patients （32 wom...Objective To evaluate metabolic abnormalities in patients with mesial temporal lobe epilepsy （MTLE） with proton magnetic resonance spectroscopy （MRS） using a 3.0T MR scanner. Methods Sixty-three patients （32 women and 31 men） with diagnosed MTLE underwent diagnostic MR imaging （MRI） and proton MRS using a 3.0T MR scanner. The clinical history and interictal epileptiform discharges （IEDs） were recorded. Sixteen healthy volunteers served as control. The results of proton MRS were compared with the findings of electroencephalogram and structural MRI findings. Results Twenty-seven of the 63 patients with MTLE showed unilateral hippocampal sclerosis, and 9 showed bilateral hippocampal sclerosis. The concentration ratio of N-acytelaspartate （NAA） / [ creatine （ Cr ） ＋ choline （Cho） ] in the hippocampal region of MTLE patients （0. 64±0. 07） was significantly lower than control （0. 80±0. 05, P = 0.023）. In the patients with unilateral hippocampal sclerosis, NAA/（Cr ＋ Cho） in the hippocampal region ipsilateral to the sclerotic hippocampus （0.56±0.06） was significantly lower than the ratio in the contralateral hippocampal region （0.69±0.07, P 〈 0. 001 ）. There was significant difference in hippocampal NAA/（ Cr ＋ Cho） between the refractory patients and the non-refractory patients （0. 64±0. 05 vs.0.71±0. 07, P =0. 04）. Forty-five patients were lateralized by IEDs, while 49 patients were lateralized by metabolite ratio. And lateralization determined by proton MRS and IEDs was concordant in 33 patients. Conclusions MRS as a noninvasive tool adds helpful metabolite information to routine MRI in evaluation of MTLE. The method is well established and should be a routine clinical application in the investigation of epilepsy.展开更多
Objective:To investigate gender difference in the effects of daytime sleep on item and source memories,which are dissociable elements of declarative memory,and the effects of sleep on recollection and familiarity,whic...Objective:To investigate gender difference in the effects of daytime sleep on item and source memories,which are dissociable elements of declarative memory,and the effects of sleep on recollection and familiarity,which are two processes underlying recognition. Methods:Participants saw a series of pictures with either blue or red background,and were then given a pretest for item and source memories. Then males and females respectively were randomly assigned either to a wake or a sleep condition. In the wake condition,participants remained awake until the posttest;in the sleep condition,participants slept for 1 h until awakened and asked to remain awake until the posttest. Results:Daytime sleep contributed to retention of source memory rather than item memory in females,whereas males undergoing daytime sleep had a trend towards increased familiarity. For females,however,neither recollection nor familiarity appeared to be influenced by daytime sleep. Conclusion:The mechanism underlying gender difference may be linked with different memory traces resulting from different encoding strategies,as well as with different electrophysiological changes during daytime sleep.展开更多
文摘920333 Measurement of epidermal growthfactor on the stimulation of DNA synthesis inliver cells by flow cytometry.CHEN Tuxing (陈图兴),et al.Nanjing Med Coll.(210029) Chin
文摘Objective To evaluate metabolic abnormalities in patients with mesial temporal lobe epilepsy （MTLE） with proton magnetic resonance spectroscopy （MRS） using a 3.0T MR scanner. Methods Sixty-three patients （32 women and 31 men） with diagnosed MTLE underwent diagnostic MR imaging （MRI） and proton MRS using a 3.0T MR scanner. The clinical history and interictal epileptiform discharges （IEDs） were recorded. Sixteen healthy volunteers served as control. The results of proton MRS were compared with the findings of electroencephalogram and structural MRI findings. Results Twenty-seven of the 63 patients with MTLE showed unilateral hippocampal sclerosis, and 9 showed bilateral hippocampal sclerosis. The concentration ratio of N-acytelaspartate （NAA） / [ creatine （ Cr ） ＋ choline （Cho） ] in the hippocampal region of MTLE patients （0. 64±0. 07） was significantly lower than control （0. 80±0. 05, P = 0.023）. In the patients with unilateral hippocampal sclerosis, NAA/（Cr ＋ Cho） in the hippocampal region ipsilateral to the sclerotic hippocampus （0.56±0.06） was significantly lower than the ratio in the contralateral hippocampal region （0.69±0.07, P 〈 0. 001 ）. There was significant difference in hippocampal NAA/（ Cr ＋ Cho） between the refractory patients and the non-refractory patients （0. 64±0. 05 vs.0.71±0. 07, P =0. 04）. Forty-five patients were lateralized by IEDs, while 49 patients were lateralized by metabolite ratio. And lateralization determined by proton MRS and IEDs was concordant in 33 patients. Conclusions MRS as a noninvasive tool adds helpful metabolite information to routine MRI in evaluation of MTLE. The method is well established and should be a routine clinical application in the investigation of epilepsy.
基金supported partially by the National Basic Research Program (973) of China (No. 2006CB303101)the National Natural Science Foundation of China (No. 90820305)
文摘Objective:To investigate gender difference in the effects of daytime sleep on item and source memories,which are dissociable elements of declarative memory,and the effects of sleep on recollection and familiarity,which are two processes underlying recognition. Methods:Participants saw a series of pictures with either blue or red background,and were then given a pretest for item and source memories. Then males and females respectively were randomly assigned either to a wake or a sleep condition. In the wake condition,participants remained awake until the posttest;in the sleep condition,participants slept for 1 h until awakened and asked to remain awake until the posttest. Results:Daytime sleep contributed to retention of source memory rather than item memory in females,whereas males undergoing daytime sleep had a trend towards increased familiarity. For females,however,neither recollection nor familiarity appeared to be influenced by daytime sleep. Conclusion:The mechanism underlying gender difference may be linked with different memory traces resulting from different encoding strategies,as well as with different electrophysiological changes during daytime sleep.
