In this article, we report the preparation of a three-dimensional(3D) interconnected mesoporous anatase TiO2-SiO2 nanocomposite. The nanocomposite was obtained by using an ordered two-dimensional(2D) hexagonal mes...In this article, we report the preparation of a three-dimensional(3D) interconnected mesoporous anatase TiO2-SiO2 nanocomposite. The nanocomposite was obtained by using an ordered two-dimensional(2D) hexagonal mesoporous anatase 70 TiO2-30 SiO2-950 nanocomposite(crystallized at 950 °C for 2 h) as a precursor, NaO H as an etchant of SiO2 via a "creating mesopores in the pore walls" approach. Our strategy adopts mild conditions of creating pores such as diluted NaO H solution, appropriate temperature and solid/liquid ratio, etc. aiming at ensuring the integrities of mesopores architecture and anatase nanocrystals. XRD, TEM and N2 sorption techniques have been used to systematically investigate the physico-chemical properties of the nanocomposites. The results show that the intrawall mesopores are highly dense and uniform(average pore size 3.6 nm), and highly link the initial mesochannels in a 3D manner while retaining mesostructural integrity. There is no significant change to either crystallinity or size of the anatase nanocrystals before and after creating the intrawall mesopores. The photocatalytic degradation rates of rhodamine B(RhB, 0.303 min^–1) and methylene blue(MB, 0.757 min^–1) dyes on the resultant nanocomposite are very high, which are 5.1 and 5.3 times that of the precursor; even up to 16.5 and 24.1 times that of Degussa P25 photocatalyst, respectively. These results clearly demonstrate that the 3D interconnected mesopores structure plays an overwhelming role to the increments of activities. The 3D mesoporous anatase TiO2-SiO2 nanocomposite exhibits unexpected-high degradation activities to RhB and MB in the mesoporous metal oxide-based materials reported so far. Additionally, the nanocomposite is considerably stable and reusable. We believe that this method would pave the way for the preparation of other 3D highly interconnected mesoporous metal oxide-based materials with ultra-high performance.展开更多
Micromixing efficiency of viscous media in Y-type micro-channel reactor was studied by using iodide-iodate test reaction as working system.Experiments were carried out in water-glycerin mixtures with 7 different visco...Micromixing efficiency of viscous media in Y-type micro-channel reactor was studied by using iodide-iodate test reaction as working system.Experiments were carried out in water-glycerin mixtures with 7 different viscosities.The experimental results showed that segregation index of the micro-channel reactor increases with the decrease of volumetric flow rate and the increase of solution viscosity.Based on the incorporation model,the micromixing time tm of the micro-channel reactor was estimated in the range of 10-4-10-3s at different viscosities,which indicated that the micro-channel reactor possesses a much better micromixing performance compared to the stirred tank(tm=0.02-0.2s).展开更多
In this work an experimental study combined with an analytical investigation for cooling superheated Carbon Dioxide (CO2) gas were carried out. This work is intended to be part of the super critical Gustav Lorentzen...In this work an experimental study combined with an analytical investigation for cooling superheated Carbon Dioxide (CO2) gas were carried out. This work is intended to be part of the super critical Gustav Lorentzen refrigeration cycle of CO2. Experimental and analytical works concentrated on heat transfer and pressure drop for single phase flow during gas cooling inside tubes filled with porous media. Analytical empirical correlations were formulated for the coefficient of convectional heat transfer and for the pressure drop. A comparison between experimental results and that obtained by developed correlations were carried out, and a comparison between these results and literature published ones were carried out too. The results of this research showed that for cooling process the proposed correlations were proved to be acceptably accurate for pressure drop with difference from experimental results of 2%, while for convective heat transfer the difference from experimental results reached about 3%. More than 90% agreement with literature results was obtained. This work can enhance the calculations of heat flux and pressure drop of gases flow inside porous media filled tubes, and can help in the design procedure of heat exchangers and cooling processes.展开更多
AIM: To evaluate the therapeutic effects of a probiotic supplement (Clostridium butyricum, CGMCC0313 ) in a chemically-induced rat model of experimental colitis. METHODS: An experimental ulcerative colitis model w...AIM: To evaluate the therapeutic effects of a probiotic supplement (Clostridium butyricum, CGMCC0313 ) in a chemically-induced rat model of experimental colitis. METHODS: An experimental ulcerative colitis model was established by rectal injection of oxazolone into the colon of 40 Wistar rats randomly divided into four groups. The positive control group was sacrificed 3 d after colitis onset. The remaining groups were fed daily with either 2 mL of C. butyricum (2.3 × 10^11 CFU/L), 2 mL of mesalamine (100 g/L), or 1 mL of sodium butyrate (50 mmol/L) for 21 d. The animals' body weight, behavior, and bowel movements were recorded weekly. After sacrifice, visual and microscopic observations of pathological changes of colon tissue were made, body weight and wet colon mass index were measured and recorded, and serum levels of interleukin-23 (IL-23) and TNF-α were measured using ELISA. Expression of calcitonin gene-related peptide in colon tissue was measured by RT-PCR. Finally, changes in rat intestinal microflora status were measured in all groups.lowered the serum levels of both IL-23 and tumor necrosis factor-α (TNF-α) with similar or even better efficiency than that of mesalamine or sodium butyrate. The rat intestinal flora appeared to recover more quickly in the group treated with C. butyricum than in the mesalamine and sodium butyrate groups. Finally, we found that the expression level of calcitonin gene related peptide was elevated in colon tissue in the sodium butyrate treated group but not in the C. butyricum or mesalamine treated groups, indicating a sensitization of colon following sodium butyrate treatment. CONCLUSION: In our experimental colitis model, treatment with C. butyricum CGMCC0313, a probiotic supplement, is at least as efficient as treatment with mesalamine.展开更多
Objective To study the mechanism and effect of lipid lowering drugs in arresting the development of arterial restenosis after angioplasty. Methods De-endothelialization injury of rabbit aortae, common iliac and femo...Objective To study the mechanism and effect of lipid lowering drugs in arresting the development of arterial restenosis after angioplasty. Methods De-endothelialization injury of rabbit aortae, common iliac and femoral arteries using balloon angioplasty and the expression of growth factors such as platelet derived growth factor-B (PDGF-B), transforming growth factor β-1 (TGFβ-1), and fibroblast growth factos (bFGF) were investigated. Total serum cholesterol (TC) and triglycerides (TG) were analyzed during and after the treatment using either simvastatin combined with gemfibrozil or simvastatin alone for 6 weeks.Results Serum total cholesterol and triglycerides were only slightly to moderately increased after high cholesterol ration intake lasting for 6 weeks in rabbits of two therapeutic groups (simvastatin plus gemfibrozil or only simvastatin). A positive correlation was found between TC and intimal/medial ratio (r=0.5873, P<0.05). PDGF-B detected by immuno-histochemistry and RT-PCR analysis showed that the release of PDGF-B was inhibited by simvastatin and gemfibrozil after de-endothelialization. RT-PCR analysis showed that TGFβ-1 was increased in the neointima in two treatment groups but no definite change was seen in the mRNA of bFGF in the smooth muscle cell (SMC) of the balloon-injured arteries even under lipid lowering drug treatment. Conclusion In addition to the lipid lowering effect, both simvastatin and gemfibrozil also influence the release of PDGF-Band TGF-1 in the neointima after de-endothelialization.展开更多
基金supported by the National Natural Science Foundation of China(21373056)the Science and Technology Commission of Shanghai Municipality(13DZ2275200)~~
文摘In this article, we report the preparation of a three-dimensional(3D) interconnected mesoporous anatase TiO2-SiO2 nanocomposite. The nanocomposite was obtained by using an ordered two-dimensional(2D) hexagonal mesoporous anatase 70 TiO2-30 SiO2-950 nanocomposite(crystallized at 950 °C for 2 h) as a precursor, NaO H as an etchant of SiO2 via a "creating mesopores in the pore walls" approach. Our strategy adopts mild conditions of creating pores such as diluted NaO H solution, appropriate temperature and solid/liquid ratio, etc. aiming at ensuring the integrities of mesopores architecture and anatase nanocrystals. XRD, TEM and N2 sorption techniques have been used to systematically investigate the physico-chemical properties of the nanocomposites. The results show that the intrawall mesopores are highly dense and uniform(average pore size 3.6 nm), and highly link the initial mesochannels in a 3D manner while retaining mesostructural integrity. There is no significant change to either crystallinity or size of the anatase nanocrystals before and after creating the intrawall mesopores. The photocatalytic degradation rates of rhodamine B(RhB, 0.303 min^–1) and methylene blue(MB, 0.757 min^–1) dyes on the resultant nanocomposite are very high, which are 5.1 and 5.3 times that of the precursor; even up to 16.5 and 24.1 times that of Degussa P25 photocatalyst, respectively. These results clearly demonstrate that the 3D interconnected mesopores structure plays an overwhelming role to the increments of activities. The 3D mesoporous anatase TiO2-SiO2 nanocomposite exhibits unexpected-high degradation activities to RhB and MB in the mesoporous metal oxide-based materials reported so far. Additionally, the nanocomposite is considerably stable and reusable. We believe that this method would pave the way for the preparation of other 3D highly interconnected mesoporous metal oxide-based materials with ultra-high performance.
基金Supported by the National-Natural Science Foundation of China (20821004, 20806004) and the National High Technology Research and Development Program of China (2007AA030207, 2006AA030202, 2006AA030203).
文摘Micromixing efficiency of viscous media in Y-type micro-channel reactor was studied by using iodide-iodate test reaction as working system.Experiments were carried out in water-glycerin mixtures with 7 different viscosities.The experimental results showed that segregation index of the micro-channel reactor increases with the decrease of volumetric flow rate and the increase of solution viscosity.Based on the incorporation model,the micromixing time tm of the micro-channel reactor was estimated in the range of 10-4-10-3s at different viscosities,which indicated that the micro-channel reactor possesses a much better micromixing performance compared to the stirred tank(tm=0.02-0.2s).
文摘In this work an experimental study combined with an analytical investigation for cooling superheated Carbon Dioxide (CO2) gas were carried out. This work is intended to be part of the super critical Gustav Lorentzen refrigeration cycle of CO2. Experimental and analytical works concentrated on heat transfer and pressure drop for single phase flow during gas cooling inside tubes filled with porous media. Analytical empirical correlations were formulated for the coefficient of convectional heat transfer and for the pressure drop. A comparison between experimental results and that obtained by developed correlations were carried out, and a comparison between these results and literature published ones were carried out too. The results of this research showed that for cooling process the proposed correlations were proved to be acceptably accurate for pressure drop with difference from experimental results of 2%, while for convective heat transfer the difference from experimental results reached about 3%. More than 90% agreement with literature results was obtained. This work can enhance the calculations of heat flux and pressure drop of gases flow inside porous media filled tubes, and can help in the design procedure of heat exchangers and cooling processes.
基金The Model Subject of High-Tech Industrializing Conversion of Series Microecological New Drugs,National Development and Reform Commission High-Tech,[2004]2078
文摘AIM: To evaluate the therapeutic effects of a probiotic supplement (Clostridium butyricum, CGMCC0313 ) in a chemically-induced rat model of experimental colitis. METHODS: An experimental ulcerative colitis model was established by rectal injection of oxazolone into the colon of 40 Wistar rats randomly divided into four groups. The positive control group was sacrificed 3 d after colitis onset. The remaining groups were fed daily with either 2 mL of C. butyricum (2.3 × 10^11 CFU/L), 2 mL of mesalamine (100 g/L), or 1 mL of sodium butyrate (50 mmol/L) for 21 d. The animals' body weight, behavior, and bowel movements were recorded weekly. After sacrifice, visual and microscopic observations of pathological changes of colon tissue were made, body weight and wet colon mass index were measured and recorded, and serum levels of interleukin-23 (IL-23) and TNF-α were measured using ELISA. Expression of calcitonin gene-related peptide in colon tissue was measured by RT-PCR. Finally, changes in rat intestinal microflora status were measured in all groups.lowered the serum levels of both IL-23 and tumor necrosis factor-α (TNF-α) with similar or even better efficiency than that of mesalamine or sodium butyrate. The rat intestinal flora appeared to recover more quickly in the group treated with C. butyricum than in the mesalamine and sodium butyrate groups. Finally, we found that the expression level of calcitonin gene related peptide was elevated in colon tissue in the sodium butyrate treated group but not in the C. butyricum or mesalamine treated groups, indicating a sensitization of colon following sodium butyrate treatment. CONCLUSION: In our experimental colitis model, treatment with C. butyricum CGMCC0313, a probiotic supplement, is at least as efficient as treatment with mesalamine.
文摘Objective To study the mechanism and effect of lipid lowering drugs in arresting the development of arterial restenosis after angioplasty. Methods De-endothelialization injury of rabbit aortae, common iliac and femoral arteries using balloon angioplasty and the expression of growth factors such as platelet derived growth factor-B (PDGF-B), transforming growth factor β-1 (TGFβ-1), and fibroblast growth factos (bFGF) were investigated. Total serum cholesterol (TC) and triglycerides (TG) were analyzed during and after the treatment using either simvastatin combined with gemfibrozil or simvastatin alone for 6 weeks.Results Serum total cholesterol and triglycerides were only slightly to moderately increased after high cholesterol ration intake lasting for 6 weeks in rabbits of two therapeutic groups (simvastatin plus gemfibrozil or only simvastatin). A positive correlation was found between TC and intimal/medial ratio (r=0.5873, P<0.05). PDGF-B detected by immuno-histochemistry and RT-PCR analysis showed that the release of PDGF-B was inhibited by simvastatin and gemfibrozil after de-endothelialization. RT-PCR analysis showed that TGFβ-1 was increased in the neointima in two treatment groups but no definite change was seen in the mRNA of bFGF in the smooth muscle cell (SMC) of the balloon-injured arteries even under lipid lowering drug treatment. Conclusion In addition to the lipid lowering effect, both simvastatin and gemfibrozil also influence the release of PDGF-Band TGF-1 in the neointima after de-endothelialization.