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葛根芩连汤对2型糖尿病大鼠的降血糖抗氧化作用 被引量:19
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作者 周艳 谭海荣 +2 位作者 潘竞锵 肖柳英 吕彩云 《中国新医药》 2003年第6期17-18,共2页
目的 研究葛根芩连汤对2型糖尿病大鼠血糖的影响,同时观察动物体内氧化-抗氧化作用的变化。方法 以腹腔注射小量链脲霉素(SZT)后,加饲高脂、高热量饲料10周,造成糖耐量减退(IGT)、高脂血症、肥胖、高胰岛素血症、胰岛素敏感性低下和... 目的 研究葛根芩连汤对2型糖尿病大鼠血糖的影响,同时观察动物体内氧化-抗氧化作用的变化。方法 以腹腔注射小量链脲霉素(SZT)后,加饲高脂、高热量饲料10周,造成糖耐量减退(IGT)、高脂血症、肥胖、高胰岛素血症、胰岛素敏感性低下和胰岛素抵抗(IR)的2型DM大鼠模型,测其空腹血糖征(FBG)和口服葡萄糖耐量试验(OGTT)后2小时血糖(2hBG)以及给药后2h空腹血清血糖(TSG)、超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量。结果 该方降低痛鼠FBG和OGTT后2hBG(P<0.01),改善2型DM模型大鼠的IGT;降低FSG(P<0.01)和MDA,提高SOD的活性(P<0.01)。结论 葛根芩连汤能产生磺脲类或双胍类药物的降糖和改善糖耐量作用,并具有抗氧化活性. 展开更多
关键词 葛根芩连汤 糖尿病 降血糖抗氧化作用 胰岛素抵 大鼠
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Antioxidant Activity of Polysaccharides in Yam Bulbils and Their Hypoglycemic Effect in Diabetic Mice 被引量:8
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作者 梁潇 黄月琴 +1 位作者 陈建平 郝朋伟 《Agricultural Science & Technology》 CAS 2015年第7期1332-1335,共4页
The polysaccharides in yam bulbils were extracted, and their antioxidant activity and hypoglycemic effect in diabetic mice were discussed. The results showed that the antioxidant activity of polysaccharides in yam bul... The polysaccharides in yam bulbils were extracted, and their antioxidant activity and hypoglycemic effect in diabetic mice were discussed. The results showed that the antioxidant activity of polysaccharides in yam bulbils was signifi- cantly enhanced with the increase of concentration; they showed a strong scaveng- ing ability against DPPH. and .OH, and the scavenging ability was dose dependent to some extent; the scavenging rates reached 91.15% and 89.06% respectively when the dose reached 4.0 mg/ml; the polysaccharides in yam bulbils significantly educed the blood glucose in model rice, and the hypoglycemic effect of large-dose polysaccharides was more obvious. The polysaccharides in yam bulbils has good antioxidant activity and hypoglycemic effect, which provides a new source for devel- opment of safe and natural food antioxidants and blood sugar-lowering agents. 展开更多
关键词 Yam bulbils POLYSACCHARIDES Antioxidant activity Hypoglycemic effect
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