Objective: To observe the clinical efficacy of Tuina (Chinese therapeutic massage) plus electroacupuncture in treating migraine due to liver-Yang hyperactivity and the effects on the serum levels of calcitonin gene-re...Objective: To observe the clinical efficacy of Tuina (Chinese therapeutic massage) plus electroacupuncture in treating migraine due to liver-Yang hyperactivity and the effects on the serum levels of calcitonin gene-related peptide (CGRP) and prostaglandin (PG) E_(2). Methods: A total of 122 patients with migraine due to liver-Yang hyperactivity were recruited and randomized into a control group and an observation group, each consisting of 61 cases. The control group was given Tong Nao Huo Luo acupuncture (acupuncture treatment for unblocking brain collaterals), and the observation group was Tuina treatment focusing on cervical Ashi points in addition to the intervention received by the control group. Both groups were treated once daily for 21 consecutive days. When the intervention finished, the two groups were observed for changes in the headache score, symptom and sign scores of traditional Chinese medicine (TCM), the severity of impact on life, and serum CGRP and PGE_(2) levels. The clinical efficacy was compared after 21 d of treatment. Results: The observation group had a higher total effective rate than the control group, 90.2% versus 73.8% (P<0.05);after treatment, the headache and TCM symptom and sign scores decreased in both groups (P<0.05) and were lower in the observation group than in the control group (P<0.05);the migraine’s impact on life was less severe in the observation group than in the control group (P<0.05);the levels of serum CGRP and PGE_(2) dropped in the two groups (P<0.05) and were lower in the observation group (P<0.05). Conclusion: Tong Nao Huo Luo acupuncture can produce more significant efficacy in treating migraine due to liver-Yang hyperactivity when combined with cervical Tuina at Ashi points, better alleviating the headache, improving TCM symptoms and body signs, and reducing the impact of headache on life. The mechanism may be associated with inhibiting the expression of serum pain factors CGRP and PGE_(2).展开更多
文摘Objective: To observe the clinical efficacy of Tuina (Chinese therapeutic massage) plus electroacupuncture in treating migraine due to liver-Yang hyperactivity and the effects on the serum levels of calcitonin gene-related peptide (CGRP) and prostaglandin (PG) E_(2). Methods: A total of 122 patients with migraine due to liver-Yang hyperactivity were recruited and randomized into a control group and an observation group, each consisting of 61 cases. The control group was given Tong Nao Huo Luo acupuncture (acupuncture treatment for unblocking brain collaterals), and the observation group was Tuina treatment focusing on cervical Ashi points in addition to the intervention received by the control group. Both groups were treated once daily for 21 consecutive days. When the intervention finished, the two groups were observed for changes in the headache score, symptom and sign scores of traditional Chinese medicine (TCM), the severity of impact on life, and serum CGRP and PGE_(2) levels. The clinical efficacy was compared after 21 d of treatment. Results: The observation group had a higher total effective rate than the control group, 90.2% versus 73.8% (P<0.05);after treatment, the headache and TCM symptom and sign scores decreased in both groups (P<0.05) and were lower in the observation group than in the control group (P<0.05);the migraine’s impact on life was less severe in the observation group than in the control group (P<0.05);the levels of serum CGRP and PGE_(2) dropped in the two groups (P<0.05) and were lower in the observation group (P<0.05). Conclusion: Tong Nao Huo Luo acupuncture can produce more significant efficacy in treating migraine due to liver-Yang hyperactivity when combined with cervical Tuina at Ashi points, better alleviating the headache, improving TCM symptoms and body signs, and reducing the impact of headache on life. The mechanism may be associated with inhibiting the expression of serum pain factors CGRP and PGE_(2).
