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丹参注射液生物活性限度测定方法适用性研究 被引量:7
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作者 刘倩 陈晨 +2 位作者 张媛 吴彦霖 高华 《中国药事》 CAS 2013年第9期938-941,共4页
目的探讨丹参注射液生物活性测定方法的适用性。方法采用小鼠体内血栓形成试验、兔体外血小板聚集试验和兔体外血浆活化部分凝血活酶时间(APTT)试验,观察3个厂家,每厂各1批丹参注射液的药理作用,作为生物活性测定方法和限值确定依据。结... 目的探讨丹参注射液生物活性测定方法的适用性。方法采用小鼠体内血栓形成试验、兔体外血小板聚集试验和兔体外血浆活化部分凝血活酶时间(APTT)试验,观察3个厂家,每厂各1批丹参注射液的药理作用,作为生物活性测定方法和限值确定依据。结果3批样品可明显增加血栓形成试验偏瘫恢复数,明显延长急性脑缺血试验小鼠存活时间;3批样品对二磷酸腺苷(ADP)诱导兔体外血小板聚集率有明显抑制作用,可明显延长兔血浆的活化部分凝血活酶时间(APTT),体内体外的结果作用趋势相近。结论小鼠体内血栓形成试验、兔体外血小板聚集试验和兔体外血浆活化部分凝血活酶时间(APTT)试验均可作为丹参注射液生物活性测定方法,建议限值剂量为5g生药·kg-1。选用其中1种方法测定结果阳性即可判断为合格。若结果为阴性,需加做另2种试验,结果必须均为阳性后才能判断为合格。采用生物活性测定方法可对产品进行质量内部控制,积累数据,为制定正式标准提供依据。 展开更多
关键词 丹参注射液 中药质量标准 生物活性 限度测定方法
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灯盏细辛注射液生物活性限度测定方法适用性研究 被引量:7
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作者 芮菁 张月玲 +1 位作者 李元静 唐元泰 《中国药品标准》 CAS 2010年第2期95-99,共5页
目的:探讨灯盏细辛注射液生物活性测定方法的适用性。方法:经预试验,采用小鼠体内血栓形成试验和急性脑缺血试验、大鼠体内和体外血小板聚集试验,观察不同批号灯盏细辛注射液的药理作用,作为生物活性测定方法和限值确定依据。结果:3批... 目的:探讨灯盏细辛注射液生物活性测定方法的适用性。方法:经预试验,采用小鼠体内血栓形成试验和急性脑缺血试验、大鼠体内和体外血小板聚集试验,观察不同批号灯盏细辛注射液的药理作用,作为生物活性测定方法和限值确定依据。结果:3批样品中有2批样品小鼠30mL.kg-1可明显增加血栓形成试验偏瘫恢复数,明显延长急性脑缺血试验小鼠存活时间;大鼠10mL.kg-1可降低体内血小板最大聚集率,另一批反应较弱。3批样品对ADP诱导大鼠体外血小板聚集率有明显抑制作用,体内体外结果作用趋势相近。结论:灯盏细辛注射液三批样品对不同药理模型呈现不同的活性作用差别,考虑均可作为生物活性测定方法。建议选用其中之1~2种方法和10~30mL.kg-1限值剂量对产品进行质量内部控制,积累数据,为制定正式标准提供依据。 展开更多
关键词 灯盏细辛注射液 中药质量标准 生物活性 限度测定方法
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阿奇霉素胶囊微生物限度测定及方法学验证 被引量:3
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作者 张俭俭 田志国 《中国医药导刊》 2011年第3期540-542,共3页
目的:建立阿奇霉素胶囊的微生物限度检查法及方法学验证。方法:采用常规法、离心沉淀薄膜过滤法对阿奇霉素胶囊试验菌回收率的有效性进行评价。结果:常规法试验细菌回收率低于70%,而真菌和酵母菌回收率高于70%;离心沉淀薄膜过滤法的试... 目的:建立阿奇霉素胶囊的微生物限度检查法及方法学验证。方法:采用常规法、离心沉淀薄膜过滤法对阿奇霉素胶囊试验菌回收率的有效性进行评价。结果:常规法试验细菌回收率低于70%,而真菌和酵母菌回收率高于70%;离心沉淀薄膜过滤法的试验细菌回收率高于70%。结论:阿奇霉素胶囊微生物限度检查法可用离心沉淀薄膜过滤法测定细菌数和采用常规法测定霉菌和酵母菌数,该方法可有效去除阿奇霉素胶囊中的抑菌成分,使检验结果更准确、可靠。 展开更多
关键词 阿奇霉素胶囊 微生物限度测定 回收率
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普鲁兰多糖中总氮量限度测定方法研究
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作者 姜静岩 尹晓飞 李小云 《解放军药学学报》 CAS CSCD 2015年第5期461-462,共2页
目的建立普鲁兰多糖中总氮量限度测定方法。方法采用总氮量测定通用改进方法。结果能有效地测定普鲁兰多糖中总氮量。结论改进方法反应可靠、灵敏、易于观察,可用于普鲁兰多糖中总氮量限度测定。
关键词 普鲁兰多糖 总氮量 限度测定
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北柴胡挥发油的GC-MS分析及其多组分测定 被引量:7
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作者 马媛媛 华伟 《中成药》 CAS CSCD 北大核心 2013年第12期2699-2702,共4页
目的确定北柴胡挥发油中的成分,并进行正己醛和正庚醛的限值测定。方法采用GC—MS法,分析北柴胡挥发油的成分,然后采用Gc法,对10批北柴胡药材和注射液进行正己醛和正庚醛的限值测定。结果北柴胡挥发油共确定了5种化学组分,10批北... 目的确定北柴胡挥发油中的成分,并进行正己醛和正庚醛的限值测定。方法采用GC—MS法,分析北柴胡挥发油的成分,然后采用Gc法,对10批北柴胡药材和注射液进行正己醛和正庚醛的限值测定。结果北柴胡挥发油共确定了5种化学组分,10批北柴胡药材和10批北柴胡注射液中正己醛和正庚醛的含有量限值分别为0.030—0.047mg/g和0.026—0.065mg/g,0.0071~0.0092mg/mL和0.0054~0.0077mg/mL。结论该测定方法具有良好的精密度、重复性、稳定性和回收率,能够为北柴胡药材及其注射液的质量控制提供依据。 展开更多
关键词 气质联用仪 正己醛 正庚醛 北柴胡挥发油 限度测定
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Finite Null-Subtractivity of Fuzzy Measure
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作者 李军 《Journal of Southeast University(English Edition)》 EI CAS 2000年第2期80-83,共6页
The concept of finite null subtractivity of fuzzy measure is introduced. The relations among the several kinds of convergences for sequence of measurable function are discussed by using the new structural characteris... The concept of finite null subtractivity of fuzzy measure is introduced. The relations among the several kinds of convergences for sequence of measurable function are discussed by using the new structural characteristic of fuzzy measure. Egoroff's theorem is further generalized on fuzzy measure space. 展开更多
关键词 fuzzy measure finite null subtractivity Egoroff's theorem
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Detection of Total Phenols, Essential and Toxic Elements in Latvian Whole Grain Bread
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作者 Natalia Bobere Anton Podjava Ida Jakobsone 《Journal of Chemistry and Chemical Engineering》 2012年第1期1-6,共6页
A survey was carried out with the aim of assessing the level of the total phenolic compounds (TPC), essential (Na, K, Ca, Mg, Cu, Zn) and toxic (Cd and Pb) elements in 10 Latvian whole grain rye and/or wheat flo... A survey was carried out with the aim of assessing the level of the total phenolic compounds (TPC), essential (Na, K, Ca, Mg, Cu, Zn) and toxic (Cd and Pb) elements in 10 Latvian whole grain rye and/or wheat flour bread samples, obtained from the local market. The quantities of the TPC were determined by spectrophotometry. Mineral content was determined by flame photometry, flame atom absorption spectrometry (FAAS) and electrothermal atomic absorption spectrometry (ETAA) after wet digestion in concentrated HNO3. The values were comparable to the literature data. The average content in all the samples was (on a basis of weight of the product) 547 ± 28 mg/100 g for Na; 280 ±20 mg/100 g for K; 32 ± 2 mg/100 g for Ca; 88 ±5 mg/100 g for Mg; 0.49 ± 0.09 mg/100 g for Cu; 1.6 ±0.2 mg/100 g for Zn. Both Pb and Cd were determined below the limit of detection (LOD 5 0.10 mg/100 g). The LOD values were determined for each element. The TPC content in defatted samples was slightly lower than the non-defatted ones, showing the dependence on the sample preparation. The calculated average levels of the elements were compared with the maximum levels recommended or regulated by the national legislation. 展开更多
关键词 Essential and toxic elements whole grain bread flame photometry FAAS ETAA total phenols spectrophotometry.
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Passive target tracking with intermittent measurement based on random finite set 被引量:4
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作者 罗小波 范红旗 +1 位作者 宋志勇 付强 《Journal of Central South University》 SCIE EI CAS 2014年第6期2282-2291,共10页
In the tracking problem for the maritime radiation source by a passive sensor,there are three main difficulties,i.e.,the poor observability of the radiation source,the detection uncertainty(false and missed detections... In the tracking problem for the maritime radiation source by a passive sensor,there are three main difficulties,i.e.,the poor observability of the radiation source,the detection uncertainty(false and missed detections)and the uncertainty of the target appearing/disappearing in the field of view.These difficulties can make the establishment or maintenance of the radiation source target track invalid.By incorporating the elevation information of the passive sensor into the automatic bearings-only tracking(BOT)and consolidating these uncertainties under the framework of random finite set(RFS),a novel approach for tracking maritime radiation source target with intermittent measurement was proposed.Under the RFS framework,the target state was represented as a set that can take on either an empty set or a singleton; meanwhile,the measurement uncertainty was modeled as a Bernoulli random finite set.Moreover,the elevation information of the sensor platform was introduced to ensure observability of passive measurements and obtain the unique target localization.Simulation experiments verify the validity of the proposed approach for tracking maritime radiation source and demonstrate the superiority of the proposed approach in comparison with the traditional integrated probabilistic data association(IPDA)method.The tracking performance under different conditions,particularly involving different existence probabilities and different appearance durations of the target,indicates that the method to solve our problem is robust and effective. 展开更多
关键词 passive target tracking maritime target joint detection and tracking intermittent measurement random finite set poor observability
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Homemade versus Commercial Jarred Baby Foods with Regard to Nitrites and Nitrates Content
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作者 Anna Bona 《Journal of Food Science and Engineering》 2017年第3期135-140,共6页
This paper presents results of nitrites and nitrates determination in two types of baby foods: commercial products in jars and their homemade conventional counterparts. Nitrites levels in all analyzed samples were be... This paper presents results of nitrites and nitrates determination in two types of baby foods: commercial products in jars and their homemade conventional counterparts. Nitrites levels in all analyzed samples were below of the detection limit (〈 0.9 mg/kg) of applied spectrophotometric method with Griess reagent. Nitrates contents in commercial products ranged: 9.1-38.1 mg/kg while in homemade baby foods levels between 26.6 mg/kg and 118.8 mg/kg were obtained. All the contents of nitrates were lower than the EU legislation maximum limit (200 mg/kg). Comparison of each type of commercial product with its homemade counterpart baby food evidenced significant differences (p 〈 0.05) in average nitrates levels in favor of the first type. Apart from determining and comparing the levels of nitrates in the baby food samples also risk assessment for an average 6-months old infant to nitrates exposure was conducted. The estimated nitrates intake with a typical portion of 200g of baby food ranged between 6% and 25.7% of acceptable daily intake for commercial and from 18.0% to 80.3% for homemade ones. 展开更多
关键词 NITRITES NITRATES baby food food safety WEANING infants.
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Limit Theorems of a Class of Super-Uniformly Elliptic Diffusions
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作者 唐加山 《Journal of Mathematical Research and Exposition》 CSCD 北大核心 2002年第3期345-350,共6页
In this paper, we investigate super-uniformly elliptic diffusions {Xt,t ≥ 0} with its branching mechanism given by ψ(z) = γz1+β(0 < ≤ 1), and, when the initial value X0(dx) is one kind of invariant measures of... In this paper, we investigate super-uniformly elliptic diffusions {Xt,t ≥ 0} with its branching mechanism given by ψ(z) = γz1+β(0 < ≤ 1), and, when the initial value X0(dx) is one kind of invariant measures of the underlying processes, we show that if dimension d satisfies βd ≤ 2, then the random measures Xt will converge to the null in distribution and if βd > 2, then Xt will converge to a nondegenerative random measure in the same sense. 展开更多
关键词 uniformly elliptic diffusion superproces limit theorem.
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