In this paper, a principal question regarding the effect of inputs on the characteristics of dynamic systems is discussed. Whether an input implemented only for a limited duration, can change the characteristics of a ...In this paper, a principal question regarding the effect of inputs on the characteristics of dynamic systems is discussed. Whether an input implemented only for a limited duration, can change the characteristics of a dynamic system such that the behavior of the free system, after eliminating the input, differs from that before acting the input？ In this paper, it is shown that a limited time acted input is not able to change the dynamical properties of a system after its elimination. Regarding the proposed approach, a novel finite duration treatment method is developed for a tumor-immune system. The vaccine therapy is used to change the parameters of the system and the chemotherapy is applied for pushing the system to the domain of attraction of the healthy state. For optimal chemotherapy, an optimal control is used based on state-dependent Riccati equation （SDRE）. It is shown that, in spite of eliminating the treatment （therapeutic inputs）, the system approaches to healthy state conditions. The present analysis suggests that a proper treatment method must change the dynamics of the cancer instead of only reducing the population of cancer cells.展开更多
文摘In this paper, a principal question regarding the effect of inputs on the characteristics of dynamic systems is discussed. Whether an input implemented only for a limited duration, can change the characteristics of a dynamic system such that the behavior of the free system, after eliminating the input, differs from that before acting the input？ In this paper, it is shown that a limited time acted input is not able to change the dynamical properties of a system after its elimination. Regarding the proposed approach, a novel finite duration treatment method is developed for a tumor-immune system. The vaccine therapy is used to change the parameters of the system and the chemotherapy is applied for pushing the system to the domain of attraction of the healthy state. For optimal chemotherapy, an optimal control is used based on state-dependent Riccati equation （SDRE）. It is shown that, in spite of eliminating the treatment （therapeutic inputs）, the system approaches to healthy state conditions. The present analysis suggests that a proper treatment method must change the dynamics of the cancer instead of only reducing the population of cancer cells.
