AIM: To investigate preoperative factors associated with poor shore-term outcome after resection for multi- nodular hepatocellular carcinoma (HCC) and to assess the contraindication of patients for surgery, METHODS...AIM: To investigate preoperative factors associated with poor shore-term outcome after resection for multi- nodular hepatocellular carcinoma (HCC) and to assess the contraindication of patients for surgery, METHODS: We retrospectively analyzed 162 multi- nodular HCC patients with Child-Pugh A liver function who underwent surgical resection. The prognostic significance of preoperative factors was investigated by univariate analysis using the log-rank test and by multivariate analysis using the Cox proportional hazards model. Each independent risk factor was then assigned points to construct a scoring model to evaluate the in- dication for surgical intervention. A receiver operating characteristics (ROC) curve was constructed to assess the predictive ability of this system.RESULTS: The median overall survival was 38.3 mo (range: 3-80 too), while the median disease-free sur- vival was 18.6 mo (range: 1-79 too). The 1-year mor- tality was 14%. Independent prognostic risk factors of 1-year death included prealburnin 〈 170 rng/L [hazard ratio (HR): 5.531, P 〈 0.001], alkaline phosphatase 〉 129 U/L (HR: 3.252, P = 0.005), α fetoprotein 〉 20 μg/L (HR: 7.477, P = 0.011), total tumor size 〉 8 cm (HR: 10.543; P 〈 0.001), platelet count 〈 100×109/L (HR: 9.937, P 〈 0.001), and y-glutamyl transpeptidase 〉 64 U/L (HR: 3.791, P 〈 0.001). The scoring model had a strong ability to predict 1-year survival (area under ROC: 0.925, P 〈 0.001). Patients with a score ≥5 had significantly poorer short-term outcome than those with a score 〈 5 (1-year mortality: 62% vs 5%, P 〈 0.001; 1-year recurrence rate: 86% vs 33%, P 〈 0.001). Patients with score ≥5 had greater possibility of microvascular invasion (P 〈 0.001), poor tumor dif- ferentiation (P = 0.003), liver cirrhosis with small nod- ules (P 〈 0.001), and intraoperative blood transfusion (P = 0.010). CONCLUSION: A composite preoperative scoring model can be used as an indication of prognosis of HCC patients after surgical resection. Resection should be considered with caution in patients with a score ≥5, which indicates a contraindication for surgery.展开更多
Gelatin from the sea cucumber(Paracaudina chinens var.) was hydrolyzed by bromelain and the hydrolysate was found to have a high free radical scavenging activity. The hydrolysate was fractionated through an ultrafiltr...Gelatin from the sea cucumber(Paracaudina chinens var.) was hydrolyzed by bromelain and the hydrolysate was found to have a high free radical scavenging activity. The hydrolysate was fractionated through an ultrafiltration membrane with 5 kDa molecular weight cutoff(MWCO). The portion(less than 5 kDa) was further separated by Sephadex G-25. The active peak was col-lected and assayed for free radical scavenging activity. The scavenging rates for superoxide anion radicals(O2·-) and hydroxyl radi-cals(·OH) of the fraction with the highest activity were 29.02% and 75.41%,respectively. A rabbit liver mitochondrial free radical damage model was adopted to study the free radical scavenging activity of the fraction. The results showed that the sea cucumber gelatin hydrolysate can prevent the damage of rabbit liver and mitochondria.展开更多
AIM To evaluate the role of albumin at the time of ulcerative colitis(UC) diagnosis in predicting the clinical course of disease.METHODS Nationwide cohort of patients with newly diagnosed UC in the Veterans Affairs he...AIM To evaluate the role of albumin at the time of ulcerative colitis(UC) diagnosis in predicting the clinical course of disease.METHODS Nationwide cohort of patients with newly diagnosed UC in the Veterans Affairs health care system was identified and divided into two categories: hypoalbuminemia(i.e.,≤ 3.5 gm/dl) or normal albumin levels(i.e.,> 3.5 gm/dl) at the time of UC diagnosis. The exposure of interest was presence of hypoalbuminemia defined asalbumin level ≤ 3.5 g/dl at the time of UC diagnosis. Patients were then followed over time to identify the use of ≥ 2 courses of corticosteroids(CS),thiopurines,anti-TNF medications and requirement of colectomy for UC management. RESULTS The eligible study cohort included 802 patients,but 92(11.4%) patients did not have their albumin levels checked at the time of UC diagnosis,and they were excluded. A total of 710 patients,who had albumin levels checked at time of UC diagnosis,were included in our study. Amongst them,536 patients had a normal albumin level and 174 patients had hypoalbuminemia. Patients with hypoalbuminemia at diagnosis had a higher likelihood of ≥ 2 courses of CS use(adjusted HR = 1.7,95%CI: 1.3-2.3),higher likelihood of thiopurine or anti-TNF use(adjusted HR = 1.72,95%CI: 1.23-2.40) than patients with normal albumin level at diagnosis. There was a trend of higher likelihood of colectomy in hypoalbuminemic patients,but it was not statistically significant(Adjusted HR = 1.7,95%CI: 0.90-3.25).CONCLUSION Hypoalbuminemia at disease diagnosis can serve as a prognostic marker to predict the clinical course of UC at the time of diagnosis.展开更多
The Microcystis aeruginosa(MA) was immobilized on sodium alginate and used as biosorbent for removal of Cd(Ⅱ) ions from aqueous solution.The biosorption process is pH dependent,and the optimum biosorption was observe...The Microcystis aeruginosa(MA) was immobilized on sodium alginate and used as biosorbent for removal of Cd(Ⅱ) ions from aqueous solution.The biosorption process is pH dependent,and the optimum biosorption was observed at pH 6.0 with the biosorption capacity of 98.38 mg/g.Among Langmuir,Freundlich and Temkin isotherm models,the Freundlich and the Temkin isotherm fit well with the experimental data.Cd(Ⅱ) ions biosorption follows the pseudo-second-order kinetic model.The rate controlling mechanism study reveals that film diffusion is the rate-limiting step and intraparticle diffusion is also involved in biosorption.Thermodynamic parameters,such as Gibbs free energy(ΔG°),the enthalpy(ΔH°) and entropy(ΔS°) were calculated,and revealed that the biosorption process is spontaneous,exothermic and random.Furthermore,the immobilized MA can be regenerated using 0.1 mol/L HCl solutions.展开更多
To investigate the clinical course of ulcerative colitis (UC) patients who develop acute pancreatitis.METHODSWe analyzed 3307 UC patients from the inflammatory bowel disease registry at Asan Medical Center from June 1...To investigate the clinical course of ulcerative colitis (UC) patients who develop acute pancreatitis.METHODSWe analyzed 3307 UC patients from the inflammatory bowel disease registry at Asan Medical Center from June 1989 to May 2015. The clinical course of UC patients who developed acute pancreatitis was compared with that of non-pancreatitis UC patients.RESULTSAmong 51 patients who developed acute pancreatitis, 13 (0.40%) had autoimmune, 10 (0.30%) had aminosalicylate-induced, and 13 (1.73%) had thiopurine-induced pancreatitis. All 13 patients with autoimmune pancreatitis (AIP) had type 2 AIP. Two (15.4%) patients had pre-existing AIP, and three (23.1%) patients developed AIP and UC simultaneously. Compared to non-pancreatitis patients, AIP patients had UC diagnosed at a significantly younger age (median, 22.9 years vs 36.4 years; P = 0.001). AIP and aminosalicylate-induced pancreatitis patients had more extensive UC compared to non-pancreatitis patients. All patients with pancreatitis recovered uneventfully, and there were no recurrences. Biologics were used more frequently in aminosalicylate- and thiopurine-induced pancreatitis patients compared to non-pancreatitis patients [adjusted OR (95%CI), 5.16 (1.42-18.67) and 6.90 (1.83-25.98), respectively]. Biologic utilization rate was similar among AIP and non-pancreatitis patients [OR (95%CI), 0.84 (0.11-6.66)]. Colectomy rates for autoimmune, aminosalicylate-induced, and thiopurine-induced pancreatitis, and for non-pancreatitis patients were 15.4% (2/13), 20% (2/10), 15.4% (2/13), and 7.3% (239/3256), respectively; the rates were not significantly different after adjusting for baseline disease extent.CONCLUSIONPancreatitis patients show a non-significant increase in colectomy, after adjusting for baseline disease extent.展开更多
PtSnNa/AlSBA-15 catalysts with different amounts of Sn were prepared for propane dehydrogenation.The catalysts were characterized by XRF,BET,H2 chemisorption,NH3-TPD,H2-TPR,and TPO techniques.Test results indicated th...PtSnNa/AlSBA-15 catalysts with different amounts of Sn were prepared for propane dehydrogenation.The catalysts were characterized by XRF,BET,H2 chemisorption,NH3-TPD,H2-TPR,and TPO techniques.Test results indicated that the presence of tin not only modified the acid function and the interfacial character between metal and support,but also reduced the coke deposition effectively.Among these catalysts investigated thereby,the PtSn(0.7%)Na/AlSBA-15 catalyst had the best catalytic performance in terms of propane conversion and stability.With the continuous addition of Sn,more amounts of Sn0 species appeared,which was unfavorable to the reaction.The PtSn(0.7%)Na/AlSBA-15 catalyst was parametrically characterized in order to obtain necessary information to integrate the process operating conditions.A weight hourly space velocity of 3 h-1,a reaction temperature of 610 ℃ and a H2/C3H8 molar ratio of 0.25 were found to be optimum conditions for achieving a higher dehydrogenation activity of the catalyst.展开更多
PACEMAKER lead infections are rare.There are only about 0.4%-1.1% of the patients who have been implanted permanent pacemakers suffering from serious infections which lead to endocarditis.1 Generally,removal of the ...PACEMAKER lead infections are rare.There are only about 0.4%-1.1% of the patients who have been implanted permanent pacemakers suffering from serious infections which lead to endocarditis.1 Generally,removal of the infected pacemaker wire and lead,long-term anti-infection therapy,and implantation of a new pacemaker to another anatomic site are accepted approaches for these patients.展开更多
The simplification of fatigue load spectrum,which can effectively reduce experimental cost,is of great importance for structural fatigue tests.By introducing random variables,the probabilistic tolerance method of remo...The simplification of fatigue load spectrum,which can effectively reduce experimental cost,is of great importance for structural fatigue tests.By introducing random variables,the probabilistic tolerance method of removing small amplitude cycles proposed in this paper takes into account the randomness of both load and fatigue limit.The probability of the damage occurrence caused by the removed small loads is calculated to ensure that it cannot exceed the given probabilistic tolerance.Accordingly,the omission level is obtained and the truncated spectrum is formed.The unnotched aluminum sheet specimens are used to perform the fatigue test on the original fatigue spectrum and truncated fatigue spectrum of a transporter.The test results show that there is no statistical difference between the test life of the truncated spectrum and that of the original spectrum,which demonstrates the validity of the small-load-omitting method that considers randomness.展开更多
In MIMO full duplex system,power amplifier(PA) nonlinearity limits the self-interference(SI) cancellation seriously. Most existing methods need to model and estimate the PA nonlinearity in order to reconstruct the SI,...In MIMO full duplex system,power amplifier(PA) nonlinearity limits the self-interference(SI) cancellation seriously. Most existing methods need to model and estimate the PA nonlinearity in order to reconstruct the SI,however the estimation error caused by the mismatch between the estimated PA model and the actual PA property still impacts the cancellation ability,especially when the transmit power is high. In this paper we propose a polarization oblique projection based self-interference cancellation method which does not need to estimate the PA nonlinearity coefficients. It exploits the polarization state information of the signals which is immune to the PA nonlinearity,and establishes an oblique projection operator to cancel the SI. Numerical results and analysis demonstrate that it can cancel the nonlinear SI effectively. Moreover the signal to interfere plus noise ratio(SINR) and the achievable sum rate do not deteriorate when the transmit power is high. Further,the upper bound of the achievable sum rate can be more than twice that of the half duplex.展开更多
To solve dynamic obstacle avoidance problems, a novel algorithm was put forward with the advantages of wireless sensor network (WSN). In view of moving velocity and direction of both the obstacles and robots, a mathem...To solve dynamic obstacle avoidance problems, a novel algorithm was put forward with the advantages of wireless sensor network (WSN). In view of moving velocity and direction of both the obstacles and robots, a mathematic model was built based on the exposure model, exposure direction and critical speeds of sensors. Ant colony optimization (ACO) algorithm based on bionic swarm intelligence was used for solution of the multi-objective optimization. Energy consumption and topology of the WSN were also discussed. A practical implementation with real WSN and real mobile robots were carried out. In environment with multiple obstacles, the convergence curve of the shortest path length shows that as iterative generation grows, the length of the shortest path decreases and finally reaches a stable and optimal value. Comparisons show that using sensor information fusion can greatly improve the accuracy in comparison with single sensor. The successful path of robots without collision validates the efficiency, stability and accuracy of the proposed algorithm, which is proved to be better than tradition genetic algorithm (GA) for dynamic obstacle avoidance in real time.展开更多
文摘AIM: To investigate preoperative factors associated with poor shore-term outcome after resection for multi- nodular hepatocellular carcinoma (HCC) and to assess the contraindication of patients for surgery, METHODS: We retrospectively analyzed 162 multi- nodular HCC patients with Child-Pugh A liver function who underwent surgical resection. The prognostic significance of preoperative factors was investigated by univariate analysis using the log-rank test and by multivariate analysis using the Cox proportional hazards model. Each independent risk factor was then assigned points to construct a scoring model to evaluate the in- dication for surgical intervention. A receiver operating characteristics (ROC) curve was constructed to assess the predictive ability of this system.RESULTS: The median overall survival was 38.3 mo (range: 3-80 too), while the median disease-free sur- vival was 18.6 mo (range: 1-79 too). The 1-year mor- tality was 14%. Independent prognostic risk factors of 1-year death included prealburnin 〈 170 rng/L [hazard ratio (HR): 5.531, P 〈 0.001], alkaline phosphatase 〉 129 U/L (HR: 3.252, P = 0.005), α fetoprotein 〉 20 μg/L (HR: 7.477, P = 0.011), total tumor size 〉 8 cm (HR: 10.543; P 〈 0.001), platelet count 〈 100×109/L (HR: 9.937, P 〈 0.001), and y-glutamyl transpeptidase 〉 64 U/L (HR: 3.791, P 〈 0.001). The scoring model had a strong ability to predict 1-year survival (area under ROC: 0.925, P 〈 0.001). Patients with a score ≥5 had significantly poorer short-term outcome than those with a score 〈 5 (1-year mortality: 62% vs 5%, P 〈 0.001; 1-year recurrence rate: 86% vs 33%, P 〈 0.001). Patients with score ≥5 had greater possibility of microvascular invasion (P 〈 0.001), poor tumor dif- ferentiation (P = 0.003), liver cirrhosis with small nod- ules (P 〈 0.001), and intraoperative blood transfusion (P = 0.010). CONCLUSION: A composite preoperative scoring model can be used as an indication of prognosis of HCC patients after surgical resection. Resection should be considered with caution in patients with a score ≥5, which indicates a contraindication for surgery.
文摘Gelatin from the sea cucumber(Paracaudina chinens var.) was hydrolyzed by bromelain and the hydrolysate was found to have a high free radical scavenging activity. The hydrolysate was fractionated through an ultrafiltration membrane with 5 kDa molecular weight cutoff(MWCO). The portion(less than 5 kDa) was further separated by Sephadex G-25. The active peak was col-lected and assayed for free radical scavenging activity. The scavenging rates for superoxide anion radicals(O2·-) and hydroxyl radi-cals(·OH) of the fraction with the highest activity were 29.02% and 75.41%,respectively. A rabbit liver mitochondrial free radical damage model was adopted to study the free radical scavenging activity of the fraction. The results showed that the sea cucumber gelatin hydrolysate can prevent the damage of rabbit liver and mitochondria.
文摘AIM To evaluate the role of albumin at the time of ulcerative colitis(UC) diagnosis in predicting the clinical course of disease.METHODS Nationwide cohort of patients with newly diagnosed UC in the Veterans Affairs health care system was identified and divided into two categories: hypoalbuminemia(i.e.,≤ 3.5 gm/dl) or normal albumin levels(i.e.,> 3.5 gm/dl) at the time of UC diagnosis. The exposure of interest was presence of hypoalbuminemia defined asalbumin level ≤ 3.5 g/dl at the time of UC diagnosis. Patients were then followed over time to identify the use of ≥ 2 courses of corticosteroids(CS),thiopurines,anti-TNF medications and requirement of colectomy for UC management. RESULTS The eligible study cohort included 802 patients,but 92(11.4%) patients did not have their albumin levels checked at the time of UC diagnosis,and they were excluded. A total of 710 patients,who had albumin levels checked at time of UC diagnosis,were included in our study. Amongst them,536 patients had a normal albumin level and 174 patients had hypoalbuminemia. Patients with hypoalbuminemia at diagnosis had a higher likelihood of ≥ 2 courses of CS use(adjusted HR = 1.7,95%CI: 1.3-2.3),higher likelihood of thiopurine or anti-TNF use(adjusted HR = 1.72,95%CI: 1.23-2.40) than patients with normal albumin level at diagnosis. There was a trend of higher likelihood of colectomy in hypoalbuminemic patients,but it was not statistically significant(Adjusted HR = 1.7,95%CI: 0.90-3.25).CONCLUSION Hypoalbuminemia at disease diagnosis can serve as a prognostic marker to predict the clinical course of UC at the time of diagnosis.
基金Project(41271332) supported by the National Natural Science Foundation of ChinaProject(11JJ2031) supported by the Natural Science Foundation of Hunan Province,China+1 种基金Project(2012SK2021) supported by the Science and Technology Planning Program of Hunan Province,ChinaProject(CX2012B138) supported by the Hunan Provincial Innovation Foundation for Postgraduate,China
文摘The Microcystis aeruginosa(MA) was immobilized on sodium alginate and used as biosorbent for removal of Cd(Ⅱ) ions from aqueous solution.The biosorption process is pH dependent,and the optimum biosorption was observed at pH 6.0 with the biosorption capacity of 98.38 mg/g.Among Langmuir,Freundlich and Temkin isotherm models,the Freundlich and the Temkin isotherm fit well with the experimental data.Cd(Ⅱ) ions biosorption follows the pseudo-second-order kinetic model.The rate controlling mechanism study reveals that film diffusion is the rate-limiting step and intraparticle diffusion is also involved in biosorption.Thermodynamic parameters,such as Gibbs free energy(ΔG°),the enthalpy(ΔH°) and entropy(ΔS°) were calculated,and revealed that the biosorption process is spontaneous,exothermic and random.Furthermore,the immobilized MA can be regenerated using 0.1 mol/L HCl solutions.
基金Supported by Korean Health Technology R and D Project,Ministry of Health and Welfare,South Korea,No.A120176
文摘To investigate the clinical course of ulcerative colitis (UC) patients who develop acute pancreatitis.METHODSWe analyzed 3307 UC patients from the inflammatory bowel disease registry at Asan Medical Center from June 1989 to May 2015. The clinical course of UC patients who developed acute pancreatitis was compared with that of non-pancreatitis UC patients.RESULTSAmong 51 patients who developed acute pancreatitis, 13 (0.40%) had autoimmune, 10 (0.30%) had aminosalicylate-induced, and 13 (1.73%) had thiopurine-induced pancreatitis. All 13 patients with autoimmune pancreatitis (AIP) had type 2 AIP. Two (15.4%) patients had pre-existing AIP, and three (23.1%) patients developed AIP and UC simultaneously. Compared to non-pancreatitis patients, AIP patients had UC diagnosed at a significantly younger age (median, 22.9 years vs 36.4 years; P = 0.001). AIP and aminosalicylate-induced pancreatitis patients had more extensive UC compared to non-pancreatitis patients. All patients with pancreatitis recovered uneventfully, and there were no recurrences. Biologics were used more frequently in aminosalicylate- and thiopurine-induced pancreatitis patients compared to non-pancreatitis patients [adjusted OR (95%CI), 5.16 (1.42-18.67) and 6.90 (1.83-25.98), respectively]. Biologic utilization rate was similar among AIP and non-pancreatitis patients [OR (95%CI), 0.84 (0.11-6.66)]. Colectomy rates for autoimmune, aminosalicylate-induced, and thiopurine-induced pancreatitis, and for non-pancreatitis patients were 15.4% (2/13), 20% (2/10), 15.4% (2/13), and 7.3% (239/3256), respectively; the rates were not significantly different after adjusting for baseline disease extent.CONCLUSIONPancreatitis patients show a non-significant increase in colectomy, after adjusting for baseline disease extent.
基金the Production and Research Prospective Joint Research Project(BY2009153)the Science and Technology Support Program(BE2008129) of Jiangsu Province of Chinathe National Nature Science Foundation of China(50873026) for financial supports
文摘PtSnNa/AlSBA-15 catalysts with different amounts of Sn were prepared for propane dehydrogenation.The catalysts were characterized by XRF,BET,H2 chemisorption,NH3-TPD,H2-TPR,and TPO techniques.Test results indicated that the presence of tin not only modified the acid function and the interfacial character between metal and support,but also reduced the coke deposition effectively.Among these catalysts investigated thereby,the PtSn(0.7%)Na/AlSBA-15 catalyst had the best catalytic performance in terms of propane conversion and stability.With the continuous addition of Sn,more amounts of Sn0 species appeared,which was unfavorable to the reaction.The PtSn(0.7%)Na/AlSBA-15 catalyst was parametrically characterized in order to obtain necessary information to integrate the process operating conditions.A weight hourly space velocity of 3 h-1,a reaction temperature of 610 ℃ and a H2/C3H8 molar ratio of 0.25 were found to be optimum conditions for achieving a higher dehydrogenation activity of the catalyst.
文摘PACEMAKER lead infections are rare.There are only about 0.4%-1.1% of the patients who have been implanted permanent pacemakers suffering from serious infections which lead to endocarditis.1 Generally,removal of the infected pacemaker wire and lead,long-term anti-infection therapy,and implantation of a new pacemaker to another anatomic site are accepted approaches for these patients.
基金supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)National Natural Science Foundations of China(Nos.52075244,52002181)。
文摘The simplification of fatigue load spectrum,which can effectively reduce experimental cost,is of great importance for structural fatigue tests.By introducing random variables,the probabilistic tolerance method of removing small amplitude cycles proposed in this paper takes into account the randomness of both load and fatigue limit.The probability of the damage occurrence caused by the removed small loads is calculated to ensure that it cannot exceed the given probabilistic tolerance.Accordingly,the omission level is obtained and the truncated spectrum is formed.The unnotched aluminum sheet specimens are used to perform the fatigue test on the original fatigue spectrum and truncated fatigue spectrum of a transporter.The test results show that there is no statistical difference between the test life of the truncated spectrum and that of the original spectrum,which demonstrates the validity of the small-load-omitting method that considers randomness.
基金supported by the National Natural Science Foundations of China under Grant No.61501050 and No.61271177
文摘In MIMO full duplex system,power amplifier(PA) nonlinearity limits the self-interference(SI) cancellation seriously. Most existing methods need to model and estimate the PA nonlinearity in order to reconstruct the SI,however the estimation error caused by the mismatch between the estimated PA model and the actual PA property still impacts the cancellation ability,especially when the transmit power is high. In this paper we propose a polarization oblique projection based self-interference cancellation method which does not need to estimate the PA nonlinearity coefficients. It exploits the polarization state information of the signals which is immune to the PA nonlinearity,and establishes an oblique projection operator to cancel the SI. Numerical results and analysis demonstrate that it can cancel the nonlinear SI effectively. Moreover the signal to interfere plus noise ratio(SINR) and the achievable sum rate do not deteriorate when the transmit power is high. Further,the upper bound of the achievable sum rate can be more than twice that of the half duplex.
基金Project(60475035) supported by the National Natural Science Foundation of China
文摘To solve dynamic obstacle avoidance problems, a novel algorithm was put forward with the advantages of wireless sensor network (WSN). In view of moving velocity and direction of both the obstacles and robots, a mathematic model was built based on the exposure model, exposure direction and critical speeds of sensors. Ant colony optimization (ACO) algorithm based on bionic swarm intelligence was used for solution of the multi-objective optimization. Energy consumption and topology of the WSN were also discussed. A practical implementation with real WSN and real mobile robots were carried out. In environment with multiple obstacles, the convergence curve of the shortest path length shows that as iterative generation grows, the length of the shortest path decreases and finally reaches a stable and optimal value. Comparisons show that using sensor information fusion can greatly improve the accuracy in comparison with single sensor. The successful path of robots without collision validates the efficiency, stability and accuracy of the proposed algorithm, which is proved to be better than tradition genetic algorithm (GA) for dynamic obstacle avoidance in real time.