920125 The clinical significance of detect-ing serum anti-pre S2.MENG Qin (孟勤).etal.Instit Liver Dis,Beijing Med Univ.Chin J InfectDis 1991; 9 (3): 137-140.We introduce a new ELISA inhibition test fordetecting serum...920125 The clinical significance of detect-ing serum anti-pre S2.MENG Qin (孟勤).etal.Instit Liver Dis,Beijing Med Univ.Chin J InfectDis 1991; 9 (3): 137-140.We introduce a new ELISA inhibition test fordetecting serum anti-Pre S2 in general populationpatients with different liver diseases and indi-展开更多
Objective To determine the autoantibodies and anti interferon antibody in chronic viral hepatitis patients treated with interferon and the relation of the antibodies to the curative effect of interferon. Meth...Objective To determine the autoantibodies and anti interferon antibody in chronic viral hepatitis patients treated with interferon and the relation of the antibodies to the curative effect of interferon. Methods Forty chronic viral hepatitis patients (twenty cases for hepatitis B; twenty patients for hepatitis C) were studied. Indirect immunofluorescence assay (IFA) was used to measure the autoantibodies. Enzyme immunoassay (EIA) was used to measure the anti interferon total antibody. Results Compared with normal groups, the autoantibodies in patients increased significantly (P<0.01), and the anti interferon antibody in chronic hepatitis B and hepatitis C patients had an obvious difference (P<0.05). As for the curative effect, the presence or absence of autoantibodies did not have a distinct significance in patients treated with α interferon, but the patients with anti interferon antibody before or after therapy might have a different response to α interferon. Conclusions It was suggested that the presence of auto antibodies was not a contraindication to the use of interferon in patients with chronic viral hepatitis; the clinical significance of anti interferon antidody should be further studied.展开更多
文摘920125 The clinical significance of detect-ing serum anti-pre S2.MENG Qin (孟勤).etal.Instit Liver Dis,Beijing Med Univ.Chin J InfectDis 1991; 9 (3): 137-140.We introduce a new ELISA inhibition test fordetecting serum anti-Pre S2 in general populationpatients with different liver diseases and indi-
文摘Objective To determine the autoantibodies and anti interferon antibody in chronic viral hepatitis patients treated with interferon and the relation of the antibodies to the curative effect of interferon. Methods Forty chronic viral hepatitis patients (twenty cases for hepatitis B; twenty patients for hepatitis C) were studied. Indirect immunofluorescence assay (IFA) was used to measure the autoantibodies. Enzyme immunoassay (EIA) was used to measure the anti interferon total antibody. Results Compared with normal groups, the autoantibodies in patients increased significantly (P<0.01), and the anti interferon antibody in chronic hepatitis B and hepatitis C patients had an obvious difference (P<0.05). As for the curative effect, the presence or absence of autoantibodies did not have a distinct significance in patients treated with α interferon, but the patients with anti interferon antibody before or after therapy might have a different response to α interferon. Conclusions It was suggested that the presence of auto antibodies was not a contraindication to the use of interferon in patients with chronic viral hepatitis; the clinical significance of anti interferon antidody should be further studied.
