Background.The treatment of viral warts remains challenging.A variety of treatment modalities have been used with a range of success.Fluorouracil has been shown to be effective in treating warts but the method of its ...Background.The treatment of viral warts remains challenging.A variety of treatment modalities have been used with a range of success.Fluorouracil has been shown to be effective in treating warts but the method of its delivery directly onto the affected tissue has been of little efficacy.We evaluated the safety and efficacy of intralesional 5-fluorouracil in the treatment of verrucae.Methods.Seventy-six patients with a total 315 verrucae were randomized to receive either a 5-fluorouracil, lidocaine and epinephrine (5-FU +LE) mixture or serum saline injection into the paired verrucae in the same patient.The mixture of 5-FU (4 cm3, 50 mg/mL), lidocaine (1 cm3, 20 mg/mL) and epinephrine (0.0125 mg/mL) was injected into the base of the wart using a mantoux needle.Each lesion was infiltrated with either of the solutions once a week for up to a maximum of 4 weeks, and the patientswere followed up for 6months.Results.Complete response was noted in an average of 70%of the verrucae treated with the 5-FU +LE mixture and in 29%of those in the placebo group (P < 0.001).No clinically significant systemic and local adverse effects occurred.Pain and burning were noted as an immediate injection pain.Recurrence rates were evaluated and no statistically significant difference between the two groups was found.Conclusions.The results demonstrate that treatment of verrucae with 5-FU +LE mixture is safe and effective.展开更多
Background: Bowel preparation is an important part of computed tomographic colonography (CTC); we evaluated two small-volume preparations for screening CTC with regard to quality of preparation and patient acceptabili...Background: Bowel preparation is an important part of computed tomographic colonography (CTC); we evaluated two small-volume preparations for screening CTC with regard to quality of preparation and patient acceptability. Methods: Asymptomatic subjects at average risk for colorectal cancer from a community-based CTC screening program were randomized to bowel preparation comprising magnesium/bisacodyl/picolax or polyethylene glycol (PEG)/picolax. CTC images were evaluated by a blinded investigator for residual feces and fluid; subjects completed a questionnaire regarding acceptability of the preparation. Results: In 176 subjects randomized to magnesium/bisacodyl/picolax (n = 82) or PEG/picolax (n = 94), the former preparation was discontinued because of syncope or presyncope in four (5%) subjects. Another 137 subjects received PEG/picolax without a significant adverse event. There were no other major differences in acceptability of the preparations as reported by subjects. The quality of bowel preparations for reporting CTC was similar. Conclusion: For subjects having screening CTC, both small volume bowel preparations are generally well tolerated and result in minimal fluid and fecal residue; however, the magnesium/ bisacodyl/picolax preparation was accompanied by an unacceptable incidence of syncope and is no longer used by us.展开更多
文摘Background.The treatment of viral warts remains challenging.A variety of treatment modalities have been used with a range of success.Fluorouracil has been shown to be effective in treating warts but the method of its delivery directly onto the affected tissue has been of little efficacy.We evaluated the safety and efficacy of intralesional 5-fluorouracil in the treatment of verrucae.Methods.Seventy-six patients with a total 315 verrucae were randomized to receive either a 5-fluorouracil, lidocaine and epinephrine (5-FU +LE) mixture or serum saline injection into the paired verrucae in the same patient.The mixture of 5-FU (4 cm3, 50 mg/mL), lidocaine (1 cm3, 20 mg/mL) and epinephrine (0.0125 mg/mL) was injected into the base of the wart using a mantoux needle.Each lesion was infiltrated with either of the solutions once a week for up to a maximum of 4 weeks, and the patientswere followed up for 6months.Results.Complete response was noted in an average of 70%of the verrucae treated with the 5-FU +LE mixture and in 29%of those in the placebo group (P < 0.001).No clinically significant systemic and local adverse effects occurred.Pain and burning were noted as an immediate injection pain.Recurrence rates were evaluated and no statistically significant difference between the two groups was found.Conclusions.The results demonstrate that treatment of verrucae with 5-FU +LE mixture is safe and effective.
文摘Background: Bowel preparation is an important part of computed tomographic colonography (CTC); we evaluated two small-volume preparations for screening CTC with regard to quality of preparation and patient acceptability. Methods: Asymptomatic subjects at average risk for colorectal cancer from a community-based CTC screening program were randomized to bowel preparation comprising magnesium/bisacodyl/picolax or polyethylene glycol (PEG)/picolax. CTC images were evaluated by a blinded investigator for residual feces and fluid; subjects completed a questionnaire regarding acceptability of the preparation. Results: In 176 subjects randomized to magnesium/bisacodyl/picolax (n = 82) or PEG/picolax (n = 94), the former preparation was discontinued because of syncope or presyncope in four (5%) subjects. Another 137 subjects received PEG/picolax without a significant adverse event. There were no other major differences in acceptability of the preparations as reported by subjects. The quality of bowel preparations for reporting CTC was similar. Conclusion: For subjects having screening CTC, both small volume bowel preparations are generally well tolerated and result in minimal fluid and fecal residue; however, the magnesium/ bisacodyl/picolax preparation was accompanied by an unacceptable incidence of syncope and is no longer used by us.
