Although the Japan Society of Obstetrics and Gynecology （JSOG） endorses new-type PGD using CGH for only carriers of balanced chromosomal translocations, it is against the ethical guidelines of the JSOG to decide whe...Although the Japan Society of Obstetrics and Gynecology （JSOG） endorses new-type PGD using CGH for only carriers of balanced chromosomal translocations, it is against the ethical guidelines of the JSOG to decide whether or not embryos should be implanted due to aneuploidy discovered as a result of new-type PGD. In the author＇s opinion, it should be at the discretion of the JSOG＇s own randomized controlled trials, which should involve multiple facilities, whether or not a scientific basis can be found for the value of the new-type PGD in cases of recurrent miscarriage, in cases of implantation failure, and in cases where the women are of advanced maternal age. Dr. Netsu＇s 36 cases of selective reduction may be against the Japanese Maternal Health Protection Law that prohibits abortion due to congenital disease, but with the backdrop that there are many abortions that are performed as a result of parental convenience in Japan, it is difficult to understand the difference between the over 300,000 abortions that are performed every year in Japan and Dr. Netsu＇s prescribed surgery which is designed to selectively reduce fetuses with congenital disease for the purpose of evading physical danger for women with multiple gestations.展开更多
In this article,the random walking method is used to solve the steady linear convection-diffusion equation(CDE)with disc boundary condition.The integral solution corresponding to the random walking method is deduced a...In this article,the random walking method is used to solve the steady linear convection-diffusion equation(CDE)with disc boundary condition.The integral solution corresponding to the random walking method is deduced and the relationship between the diffusion coefficient of CDE and the intensity of the random diffusion motion is obtained.The random number generator for arbitrary axisymmetric disc boundary is deduced through the polynomial fitting and inverse transform sampling method.The proposed method is tested through two numerical cases.The results show that the random walking method can solve the steady linear CDE effectively.The influence of the parameters on the results is also studied.It is found that the error of the solution can be decreased by increasing the particle releasing rate and the total walking time.展开更多
文摘Although the Japan Society of Obstetrics and Gynecology （JSOG） endorses new-type PGD using CGH for only carriers of balanced chromosomal translocations, it is against the ethical guidelines of the JSOG to decide whether or not embryos should be implanted due to aneuploidy discovered as a result of new-type PGD. In the author＇s opinion, it should be at the discretion of the JSOG＇s own randomized controlled trials, which should involve multiple facilities, whether or not a scientific basis can be found for the value of the new-type PGD in cases of recurrent miscarriage, in cases of implantation failure, and in cases where the women are of advanced maternal age. Dr. Netsu＇s 36 cases of selective reduction may be against the Japanese Maternal Health Protection Law that prohibits abortion due to congenital disease, but with the backdrop that there are many abortions that are performed as a result of parental convenience in Japan, it is difficult to understand the difference between the over 300,000 abortions that are performed every year in Japan and Dr. Netsu＇s prescribed surgery which is designed to selectively reduce fetuses with congenital disease for the purpose of evading physical danger for women with multiple gestations.
基金supported by the International Scientific and Technological Cooperation Program of China(Grant No.2011DFG13020)the China Postdoctoral Science Foundation(Grant No.2013M530043)the National Hi-Tech Research and Development Program of China("863"Project)(Grant No.2007AA05Z426)
文摘In this article,the random walking method is used to solve the steady linear convection-diffusion equation(CDE)with disc boundary condition.The integral solution corresponding to the random walking method is deduced and the relationship between the diffusion coefficient of CDE and the intensity of the random diffusion motion is obtained.The random number generator for arbitrary axisymmetric disc boundary is deduced through the polynomial fitting and inverse transform sampling method.The proposed method is tested through two numerical cases.The results show that the random walking method can solve the steady linear CDE effectively.The influence of the parameters on the results is also studied.It is found that the error of the solution can be decreased by increasing the particle releasing rate and the total walking time.
