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颅内外血管旁路移植术治疗慢性、症状性颈动脉或大脑中动脉闭塞的前瞻性、多中心、随机对照研究设计方案 被引量:4
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作者 马妍 段炼 +20 位作者 佟晓光 佟志勇 顾宇翔 王东海 王继跃 任军 阿里木江·艾力 蔡艺玲 黄玉杰 蒯东 王晓健 黄承光 游潮 曹毅 于加省 罗祺 邹安琪 黄胜平 何伟文 吉训明 凌锋 《中国脑血管病杂志》 CAS 2014年第5期277-280,共4页
1研究背景 1967年,Yasargil等首先采用颞浅动脉-大脑中动脉旁路移植术治疗缺血性脑血管病的方法[1],以颅外-颅内动脉旁路移植术(extracranial-intracranial artery bypass,EIAB)为代表的血运重建术作为缺血性脑血管病的治疗手... 1研究背景 1967年,Yasargil等首先采用颞浅动脉-大脑中动脉旁路移植术治疗缺血性脑血管病的方法[1],以颅外-颅内动脉旁路移植术(extracranial-intracranial artery bypass,EIAB)为代表的血运重建术作为缺血性脑血管病的治疗手段曾风靡一时。1985年,新英格兰医学杂志发表了前瞻性、国际多中心、随机、对照临床试验的结论--EIAB并不能降低缺血性卒中的发生率[2]。短时间内,EIAB治疗脑缺血的病例数急剧减少,但部分学者始终未放弃对此的研究。进入21世纪后,由于精确定量评价脑血流动力学方法的出现,对1985年的临床试验结论进行重新评价的呼声不断,北美国家和日本已经开始了多中心前瞻性研究工作[3-4]。 展开更多
关键词 颈动脉疾病 梗塞 大脑中动脉 血管旁路移植术 随机对照方案
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症状性颅内动脉狭窄不同疗法的多中心随机对照研究设计方案 被引量:5
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作者 高鹏 +21 位作者 焦力群 赵振伟 于嘉 蔡艺灵 崔永强 王贵平 李天晓 贺迎坤 吴伟 尹森 史怀璋 郑秉杰 何伟文 姜顺婷 尹龙 魏铭 黄胜平 白小欣 王大明 刘加春 祁鹏 凌锋 《中国脑血管病杂志》 CAS 2014年第6期329-336,共8页
1研究背景:颅内动脉狭窄治疗现状 大约10%15%的缺血性卒中是由颅内动脉粥样硬化性狭窄( intracranial atherosclerotic stenosis, ICAS)导致的。据不同文献报道,ICAS患者年卒中发生率为3%15%,每年卒中再次发作的风险高达15%17%。195... 1研究背景:颅内动脉狭窄治疗现状 大约10%15%的缺血性卒中是由颅内动脉粥样硬化性狭窄( intracranial atherosclerotic stenosis, ICAS)导致的。据不同文献报道,ICAS患者年卒中发生率为3%15%,每年卒中再次发作的风险高达15%17%。1955年,学者们开始采用华法林抗凝治疗ICAS。此后的多项回顾性研究表明华法林的效果要优于阿司匹林。直到2005年, WASID ( The Warfarin-Aspirin Symptomatic Intracranial Disease Study )研究发现,华法林的治疗效果并不优于阿司匹林,反而显著增加不良事件的发生率[1]。因此,对于ICAS患者推荐使用抗血小板聚集治疗。 展开更多
关键词 颅内动脉疾病 多中心研究 随机对照方案 症状性颅内动脉狭窄
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单病例随机对照试验方案清单(SPENT 2019)解读 被引量:1
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作者 李艳飞 储夏静 +4 位作者 卢存存 韩嘉妮 郑忠礼 李秀霞 杨克虎 《中国循证医学杂志》 CSCD 北大核心 2022年第4期475-482,共8页
单病例随机对照试验(N-of-1 trials)是一种基于单个患者所设计的多轮试验期交替的前瞻性临床随机交叉对照试验,可为临床决策者提供干预措施效果比较的高级别证据。近期,由多位学者组成的国际团队在BMJ上发表了N-of-1 trials方案规范清单... 单病例随机对照试验(N-of-1 trials)是一种基于单个患者所设计的多轮试验期交替的前瞻性临床随机交叉对照试验,可为临床决策者提供干预措施效果比较的高级别证据。近期,由多位学者组成的国际团队在BMJ上发表了N-of-1 trials方案规范清单(SPENT 2019),目的在于明确N-of-1 trials方案的内容设计,提高研究方案的完整性和透明度。本文将结合具体实例对SPENT 2019清单的14个主要扩展子条目进行详细解读,以期进一步规范国内N-of-1 trials研究的发表。 展开更多
关键词 单病例随机对照试验 报告规范 报告质量 单病例随机对照试验方案清单(SPENT 2019)
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Calcium dobesilate for diabetic retinopathy: a systematic review and meta-analysis 被引量:55
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作者 ZHANG XinYuan LIU Wei +3 位作者 WU ShanShan JIN JingLong LI WeiHong Wang NingLi 《Science China(Life Sciences)》 SCIE CAS CSCD 2015年第1期101-107,共7页
Many randomized clinical controlled trials have confirmed the efficacy and safety of calcium dobesilate in treating diabetic retinopathy(DR).This systematic review critically evaluated the evidence that links calcium ... Many randomized clinical controlled trials have confirmed the efficacy and safety of calcium dobesilate in treating diabetic retinopathy(DR).This systematic review critically evaluated the evidence that links calcium dobesilate to DR.In this fixed-effects meta-analysis,a total of 221 pertinent English-language articles published between January 1975 and October 2013 were identified.Systematic searches of PUBMED,Springer Link and the Cochrane Clinical Trials Database were conducted using the keywords "diabetic retinopathy" and "calcium dobesilate".The extracted information included the study design,inclusion and exclusion criteria,setting,sample size,participant mean age,treatment regime,mean change in best corrected visual acuity,laboratory parameters,capillary fragility,intraocular pressure and fundus manifestations based on the findings of fluorescent angiography.The summary statistics indicated that calcium dobesilate was significantly associated with improving retinal microaneurysms(RR: 0.62,95%CI: 0.42?0.90,P=0.01),retinalhemorrhages(RR: 0.39,95% CI: 0.17?0.88,P=0.02); exudates(RR: 0.31,95% CI: 0.12?0.81,P=0.02),reduction of whole blood viscosity(MD: ?0.57 CP,95% CI: ?0.75 to ?0.38,P<0.001),plasma viscosity(MD: ?0.36 CP,95% CI: ?0.63 to ?0.09,P=0.01) and blood cholesterol(MD: ?0.48 mg m L?1,95% CI: ?0.64?0.33,P<0.00001).Intraocular pressure was also significantly reduced(MD: ?5.59 mm Hg,95% CI: ?6.69 to ?4.50,P<0.00001).The results indicate that calcium dobesilate effectively treats DR at the systematic and local ocular levels. 展开更多
关键词 diabetic retinopathy calcium dobesilate randomized controlled clinical trial systemic review META-ANALYSIS
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Long-term effectiveness of moxibustion on herbs for moderate-severe persistent allergic rhinitis population:A study protocol for a randomized controlled trial 被引量:2
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作者 Yi-fan JIA Ji-ping ZHAO,Sheng-nan GUO +2 位作者 Qi XIE Yi XIAO Sheng CHEN 《World Journal of Acupuncture-Moxibustion》 CSCD 2018年第3期212-217,I0007,共7页
Background: Allergic rhinitis(AR) is defined as an immunoglobulin led atopic disorder that affects the nasal mucosa. Moxibustion on herbs, a common complementary and alternative medicine approach, is frequently use... Background: Allergic rhinitis(AR) is defined as an immunoglobulin led atopic disorder that affects the nasal mucosa. Moxibustion on herbs, a common complementary and alternative medicine approach, is frequently used for treating AR in clinical practice. Western medicine is good at quick symptomatic relief,while offer little or no sustainable and steady long-term effect. Little established evidence is available to support the long-term effectiveness of moxibustion on herbs for AR.Objective: This study is a randomized controlled trial to assess the long-term effectiveness of moxibustion on herbs in moderate-severe persistent AR population.Methods: The study sample size is 56 patients. Eligible patients with moderate-severe persistent AR will be randomized into a moxibustion on herbs combined with conventional treatment group(MOHCT group) and a conventional treatment group(CT group) in a 1:1 ratio. Patients in the MOHCT group will receive a 30-min moxibustion on herbs treatment on Zhiyang(至阳 GV 9), Dàzhuī(大椎 GV 14) and bilateral Shenshu(肾俞 BL 23), Fèishū(肺俞 BL 13) for a total of 12 times on the basis of conventional treatment, while those in the CT group will receive conventional treatment alone. The primary outcome measure is VAS score for total nasal symptoms, which will be obtained via a self-recorded AR diary. The secondary outcome measures include the average occurrence of symptoms per week, use of medication and Rhinoconjunctivitis Quality of Life Questionnaire(RQLQ).Discussion: The objectives of this study include(1) to evaluate the long-term effectiveness and safety of moxibustion on herbs for treating AR;(2) to evaluate whether moxibustion on herbs can reduce the frequency of AR symptoms in patients with moderate-severe persistent allergic rhinitis. The finding of this study will provide evidence on the long-term effectiveness of moxibustion on herbs for moderatesevere persistent AR. 展开更多
关键词 Moxibustion on herbs Moderate-severe persistent Allergic rhinitis Long-term effectiveness Randomized controlled trial (RCT) Protocol
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