In this study, an improved random access(RA) scheme for Machine-to-Machine(M2M) communications is proposed. The improved RA scheme is realized by two steps. First, the improved RA scheme achieves a reasonable resource...In this study, an improved random access(RA) scheme for Machine-to-Machine(M2M) communications is proposed. The improved RA scheme is realized by two steps. First, the improved RA scheme achieves a reasonable resource tradeoff between physical random access channel(PRACH) and physical uplink shared channel(PUSCH). To realize a low-complexity resource allocation between PRACH and PUSCH, a boundary of traffic load is derived to divide the number of active M2 M users(UEs) into multiple intervals. The corresponding resource allocation for these intervals is determined by e NB. Then the resource allocation for other number of UEs can be obtained from the allocation of these intervals with less computation. Second, the access barring on arrival rate of new UEs is introduced in the improved RA scheme to reduce the expected delay. Numerical results show that the proposed improved RA scheme can realize a low-complexity resource allocation between PRACH and PUSCH. Meanwhile, the expected delay can be effectively reduced by access barring on arriving rate of new M2 M UEs.展开更多
Objective To investigate if low dose total body irradiation (TBI, 6.0- 9.0 Gy) combined with intensified chemotherapy followed by autologous peripheral blood stem cell transplantation results in better survival in ch...Objective To investigate if low dose total body irradiation (TBI, 6.0- 9.0 Gy) combined with intensified chemotherapy followed by autologous peripheral blood stem cell transplantation results in better survival in children with refractory leukemia or solid tumors.Methods Twenty-one children with malignant tumors were included in this study. There were 14 males and 7 females aged 3.5- 12 years. Underlying disease included high-risk acute lymphoblastic leukemia (ALL, CR1 in 3 children and CR2 in 5 children), acute myeloblastic leukemia (AML, 9 children), nonHodgkin' s lymphoma stage Ⅳ (2 children), and neuroblastoma stage Ⅳ (2 children). The peripheral hematopoietic stem cells were collected six to eleven months after complete response, mobilized with high dose chemotherapy alone or combined with GM-CSF or G-CSF. The conditioning regimen consisted of chemotherapy with two to three combinations of the following drugs: cyclophosphamide,arabinosylcytosine, McNU, etopside, and Idarubicin on the basis of TBI (6.0-9.0Gy). A mean of (1.8 ± 0.5) × 108/kg autologous mononuclear cells were transplanted. The patients were followed up after transplantation.Results Severe bone marrow suppression occurred in all patients around day + 7. Peripheral white blood cell count decreased to 0 in all patients at day + 4.8 ± 2.9, and platelet count decreased to less than 20× 109/L at day + 9.0 ± 2.6. Successful engraftment was achieved in 21 patients, but four died of infection at day + 17, + 20, + 31 and + 67, respectively. Recovery of white blood cell (WBC) to 10 × 109/L, absolute neutrophil count to 0.5 × 109/L, platelet count to 20 × 109/L occurred on 21 ± 12,26± 13, and 27 ± 10 days, respectively. During the follow up period, three patients relapsed at + 5months, + 1.5 years, and + 2 years 10 months, respectively. One patient died of intracranial hemorrhage at +8 months. Thirteen patients had event-free survival for 2 - 12 years, with a mean of 6.7±3.4 years.Conclusion Our preliminary data suggest that myeloablative therapy with low dose TBI (6.0 - 9.0 Gy)combined with intensified chemotherapy followed by autologous paripheral blood stem cell transplantation might be associated with favorable results in children with refractory leukemia or solid tumors.展开更多
基金supported by Key Laboratory of Universal Wireless Communications(Beijing University of Posts and Telecommunications),Ministry of Education,P.R.China,KFKT-2014103)National Science and Technology Major Project of China(No.2013ZX03006001)National Natural Science Foundation of China(61501056)
文摘In this study, an improved random access(RA) scheme for Machine-to-Machine(M2M) communications is proposed. The improved RA scheme is realized by two steps. First, the improved RA scheme achieves a reasonable resource tradeoff between physical random access channel(PRACH) and physical uplink shared channel(PUSCH). To realize a low-complexity resource allocation between PRACH and PUSCH, a boundary of traffic load is derived to divide the number of active M2 M users(UEs) into multiple intervals. The corresponding resource allocation for these intervals is determined by e NB. Then the resource allocation for other number of UEs can be obtained from the allocation of these intervals with less computation. Second, the access barring on arrival rate of new UEs is introduced in the improved RA scheme to reduce the expected delay. Numerical results show that the proposed improved RA scheme can realize a low-complexity resource allocation between PRACH and PUSCH. Meanwhile, the expected delay can be effectively reduced by access barring on arriving rate of new M2 M UEs.
文摘Objective To investigate if low dose total body irradiation (TBI, 6.0- 9.0 Gy) combined with intensified chemotherapy followed by autologous peripheral blood stem cell transplantation results in better survival in children with refractory leukemia or solid tumors.Methods Twenty-one children with malignant tumors were included in this study. There were 14 males and 7 females aged 3.5- 12 years. Underlying disease included high-risk acute lymphoblastic leukemia (ALL, CR1 in 3 children and CR2 in 5 children), acute myeloblastic leukemia (AML, 9 children), nonHodgkin' s lymphoma stage Ⅳ (2 children), and neuroblastoma stage Ⅳ (2 children). The peripheral hematopoietic stem cells were collected six to eleven months after complete response, mobilized with high dose chemotherapy alone or combined with GM-CSF or G-CSF. The conditioning regimen consisted of chemotherapy with two to three combinations of the following drugs: cyclophosphamide,arabinosylcytosine, McNU, etopside, and Idarubicin on the basis of TBI (6.0-9.0Gy). A mean of (1.8 ± 0.5) × 108/kg autologous mononuclear cells were transplanted. The patients were followed up after transplantation.Results Severe bone marrow suppression occurred in all patients around day + 7. Peripheral white blood cell count decreased to 0 in all patients at day + 4.8 ± 2.9, and platelet count decreased to less than 20× 109/L at day + 9.0 ± 2.6. Successful engraftment was achieved in 21 patients, but four died of infection at day + 17, + 20, + 31 and + 67, respectively. Recovery of white blood cell (WBC) to 10 × 109/L, absolute neutrophil count to 0.5 × 109/L, platelet count to 20 × 109/L occurred on 21 ± 12,26± 13, and 27 ± 10 days, respectively. During the follow up period, three patients relapsed at + 5months, + 1.5 years, and + 2 years 10 months, respectively. One patient died of intracranial hemorrhage at +8 months. Thirteen patients had event-free survival for 2 - 12 years, with a mean of 6.7±3.4 years.Conclusion Our preliminary data suggest that myeloablative therapy with low dose TBI (6.0 - 9.0 Gy)combined with intensified chemotherapy followed by autologous paripheral blood stem cell transplantation might be associated with favorable results in children with refractory leukemia or solid tumors.
