AIM： To investigate the effect of two-channel gastric electrical stimulation （GES） with trains of pulses on gastric emptying and slow waves.METHODS： Seven dogs implanted with four pairs of electrodes and equipped ...AIM： To investigate the effect of two-channel gastric electrical stimulation （GES） with trains of pulses on gastric emptying and slow waves.METHODS： Seven dogs implanted with four pairs of electrodes and equipped with a duodenal cannula were involved in this study. Two experiments were performed.The first experiment included a series of sessions in the fasting state with trains of short or long pulses, each lasted 10 min. A 5-min recording without pacing was made between two sessions. The second experiment was performed in three sessions （control, single-channel GES, and two-channel GES）. The stimulus was applied via the 1st pair of electrodes for single-channel GES （GES via one pair of electrodes located at 14 cm above the pylorus）, and simultaneously via the 1st and 3rd channels for two-channel GES （GES via two pairs of electrodes located at 6 and 14 cm above the pylorus）, Gastric liquid emptying was collected every 15 min via the cannula for 90 min.RESULTS： GES with trains of pulses at a pulse width of 4 ms or higher was able to entrain gastric slow waves. Two-channel GES was about 50% more efficient than single-channel GES in entraining gastric slow waves. Two-channel but not single-channel GES with trains of pulses was capable of accelerating gastric emptying in healthy dogs. Compared with the control session, two-channel GES significantly increased gastric emptying of liquids at 15 rain （79.0% ± 6.4% vs 61.3% ± 6.1%, P 〈 0.01）, 30 min （83.2% ± 6.3 % vs 68.2% ± 6.9%, P 〈 0.01）, 60 min （86.9% ± 5.5 % vs 74.1% ± 5.9%, P 〈 0.01）, and 90 rain （91.0% ± 3.4% vs 76.5% ± 5.9%, P 〈 0.01）.CONCLUSION： Two-channel GES with trains of pulses accelerates gastric emptying in healthy dogs and may have a therapeutic potential for the treatment of gastric motility disorders.展开更多
Objective To seek a better therapy for treating post-stroke dysphagia. Methods Patients with stroke and swallowing disorders were randomly divided into ordinary acupuncture group （group A, 58 cases） and swallowing n...Objective To seek a better therapy for treating post-stroke dysphagia. Methods Patients with stroke and swallowing disorders were randomly divided into ordinary acupuncture group （group A, 58 cases） and swallowing neuromuscular electrical stimulation combined with acupuncture group （group B, 62 cases）. Two-group patients were given the same basic internal medical treatment. In addition, group A was given normal acupuncture treatment with the choice of local points： Junjin （金津 EX-HN 12）, Yuye（玉液 EX-HN 23）, Fengchi （风池 GB 20）, Yifeng （翳风 TE 17）, Lianquan （廉泉 CV 23）, Wangu （完骨 GB 12）. Group B was given swallowing neuromuscular electrical stimulation combined with acupuncture： GB 20, Fengfu （风夜 GV 16）, TE 17, Yiming （翳明 EX-HN 14）, Yamen （哑门 GV 15）, Tianrong（天容 SI 17）, Tianchuang （天窗 SI 16）, CV 23, the uniform reinforcing-reducing manipulation was used; EX- HN 12, EX-HN 13, the piercing and blood-letting method （1-2 mL blood） was used; at the same time, the swallowing neuromuscular electrical stimulation therapy device was used to electrically stimulate the nerves and muscles in the throat and neck at specific output pulse current （50-100 Hz）. Treatment was made twice a day, 30 minutes each time. Two weeks after the treatment, the patients were assessed in symptoms improvement and clinical efficacy. Results The total effective rate in group B was 91.4% and 75.8% in group A; in the total efficiency comparison in both groups, χ^2=5.232, P〈0.05. The difference in improvement of symptoms with post-stroke dysphagia treated with above mentioned combination treatment was statistically significant between both groups （P〈0.05）. Conclusion The above mentioned swallowing neuromuscular electrical stimulation combined with acupuncture treatment has a better clinical effect when compared with ordinary acupuncture.展开更多
Voiding dysfunction,such as urge-frequency syndrome,urge incontinence,stress incontinence and unobstructive urinary retention,is often refractory to pharmacotherapy.Electrical neuromodulation has proved to be benefici...Voiding dysfunction,such as urge-frequency syndrome,urge incontinence,stress incontinence and unobstructive urinary retention,is often refractory to pharmacotherapy.Electrical neuromodulation has proved to be beneficial for these situations.Electroacupuncture pudendal nerve stimulation(EPNS),as one therapy of electrical neuromodulation,is beneficial for voiding dysfunction.The performance and application of EPNS will be introduced in this article.展开更多
Objective：To investigate the effect of electrical stimulation to sacral spinal nerve 3 （S3 stimulation） on gastrointestinal dysfunction after spinal cord injury （SCI）.Methods：Six rabbits were taken as normal con...Objective：To investigate the effect of electrical stimulation to sacral spinal nerve 3 （S3 stimulation） on gastrointestinal dysfunction after spinal cord injury （SCI）.Methods：Six rabbits were taken as normal controls to record their gastrointestinal multipoint biological discharge,colon pressure and rectoanal inhibitory reflex.Electrodes were implanted into S3 in another 18 rabbits.Then the model of SCI was conducted following Fehling＇s method：the rabbit S3 was clamped to induce transverse injury,which was claimed by both somatosensory evoked potential and motion evoked potential.Two hours after SCI,S3 stimulation was conducted.The 18 rabbits were subdivided into 3 groups to respectively record their gastrointestinal electric activities （n=6）,colon pressure （n=6）,and rectum pressure （n=6）.Firstly the wave frequency was fixed at 15 Hz and pulse width at 400 μs and three stimulus intensities （6 V,8 V,10 V） were tested.Then the voltage was fixed at 6 V and the pulse width changed from 200 μs,400 μs to 600 μs.The response was recorded and analyzed.The condition of defecation was also investigated.Results：After SCI,the mainly demonstrated change was dyskinesia of the single haustrum and distal colon.The rectoanal inhibitory reflex almost disappeared.S3 stimulation partly recovered the intestinal movement after denervation,promoting defecation.The proper stimulus parameters were 15 Hz,400 μs,6 V,10 s with 20 s intervals and 10 min with 10 min intervals,total 2 h.Conclusion：S3 stimulation is able to restore the intestinal movement after denervation （especially single haustrum and distal colon）,which promotes defecation.展开更多
基金Supported by Funds from Union Hospital and University of Texas Medical Branch
文摘AIM： To investigate the effect of two-channel gastric electrical stimulation （GES） with trains of pulses on gastric emptying and slow waves.METHODS： Seven dogs implanted with four pairs of electrodes and equipped with a duodenal cannula were involved in this study. Two experiments were performed.The first experiment included a series of sessions in the fasting state with trains of short or long pulses, each lasted 10 min. A 5-min recording without pacing was made between two sessions. The second experiment was performed in three sessions （control, single-channel GES, and two-channel GES）. The stimulus was applied via the 1st pair of electrodes for single-channel GES （GES via one pair of electrodes located at 14 cm above the pylorus）, and simultaneously via the 1st and 3rd channels for two-channel GES （GES via two pairs of electrodes located at 6 and 14 cm above the pylorus）, Gastric liquid emptying was collected every 15 min via the cannula for 90 min.RESULTS： GES with trains of pulses at a pulse width of 4 ms or higher was able to entrain gastric slow waves. Two-channel GES was about 50% more efficient than single-channel GES in entraining gastric slow waves. Two-channel but not single-channel GES with trains of pulses was capable of accelerating gastric emptying in healthy dogs. Compared with the control session, two-channel GES significantly increased gastric emptying of liquids at 15 rain （79.0% ± 6.4% vs 61.3% ± 6.1%, P 〈 0.01）, 30 min （83.2% ± 6.3 % vs 68.2% ± 6.9%, P 〈 0.01）, 60 min （86.9% ± 5.5 % vs 74.1% ± 5.9%, P 〈 0.01）, and 90 rain （91.0% ± 3.4% vs 76.5% ± 5.9%, P 〈 0.01）.CONCLUSION： Two-channel GES with trains of pulses accelerates gastric emptying in healthy dogs and may have a therapeutic potential for the treatment of gastric motility disorders.
文摘Objective To seek a better therapy for treating post-stroke dysphagia. Methods Patients with stroke and swallowing disorders were randomly divided into ordinary acupuncture group （group A, 58 cases） and swallowing neuromuscular electrical stimulation combined with acupuncture group （group B, 62 cases）. Two-group patients were given the same basic internal medical treatment. In addition, group A was given normal acupuncture treatment with the choice of local points： Junjin （金津 EX-HN 12）, Yuye（玉液 EX-HN 23）, Fengchi （风池 GB 20）, Yifeng （翳风 TE 17）, Lianquan （廉泉 CV 23）, Wangu （完骨 GB 12）. Group B was given swallowing neuromuscular electrical stimulation combined with acupuncture： GB 20, Fengfu （风夜 GV 16）, TE 17, Yiming （翳明 EX-HN 14）, Yamen （哑门 GV 15）, Tianrong（天容 SI 17）, Tianchuang （天窗 SI 16）, CV 23, the uniform reinforcing-reducing manipulation was used; EX- HN 12, EX-HN 13, the piercing and blood-letting method （1-2 mL blood） was used; at the same time, the swallowing neuromuscular electrical stimulation therapy device was used to electrically stimulate the nerves and muscles in the throat and neck at specific output pulse current （50-100 Hz）. Treatment was made twice a day, 30 minutes each time. Two weeks after the treatment, the patients were assessed in symptoms improvement and clinical efficacy. Results The total effective rate in group B was 91.4% and 75.8% in group A; in the total efficiency comparison in both groups, χ^2=5.232, P〈0.05. The difference in improvement of symptoms with post-stroke dysphagia treated with above mentioned combination treatment was statistically significant between both groups （P〈0.05）. Conclusion The above mentioned swallowing neuromuscular electrical stimulation combined with acupuncture treatment has a better clinical effect when compared with ordinary acupuncture.
基金supported by Project of Shanghai Municipal Science and Technology Commission(09dZ1974900)Project of Shanghai Municipal Science and Technology Commission(12401904600)Project of Shanghai Municipal Health Bureau(ZYSNXD-CCZDYJ010)
文摘Voiding dysfunction,such as urge-frequency syndrome,urge incontinence,stress incontinence and unobstructive urinary retention,is often refractory to pharmacotherapy.Electrical neuromodulation has proved to be beneficial for these situations.Electroacupuncture pudendal nerve stimulation(EPNS),as one therapy of electrical neuromodulation,is beneficial for voiding dysfunction.The performance and application of EPNS will be introduced in this article.
基金This study was supported by the National Natural Science Foundation of China （No. 81101441 ）.
文摘Objective：To investigate the effect of electrical stimulation to sacral spinal nerve 3 （S3 stimulation） on gastrointestinal dysfunction after spinal cord injury （SCI）.Methods：Six rabbits were taken as normal controls to record their gastrointestinal multipoint biological discharge,colon pressure and rectoanal inhibitory reflex.Electrodes were implanted into S3 in another 18 rabbits.Then the model of SCI was conducted following Fehling＇s method：the rabbit S3 was clamped to induce transverse injury,which was claimed by both somatosensory evoked potential and motion evoked potential.Two hours after SCI,S3 stimulation was conducted.The 18 rabbits were subdivided into 3 groups to respectively record their gastrointestinal electric activities （n=6）,colon pressure （n=6）,and rectum pressure （n=6）.Firstly the wave frequency was fixed at 15 Hz and pulse width at 400 μs and three stimulus intensities （6 V,8 V,10 V） were tested.Then the voltage was fixed at 6 V and the pulse width changed from 200 μs,400 μs to 600 μs.The response was recorded and analyzed.The condition of defecation was also investigated.Results：After SCI,the mainly demonstrated change was dyskinesia of the single haustrum and distal colon.The rectoanal inhibitory reflex almost disappeared.S3 stimulation partly recovered the intestinal movement after denervation,promoting defecation.The proper stimulus parameters were 15 Hz,400 μs,6 V,10 s with 20 s intervals and 10 min with 10 min intervals,total 2 h.Conclusion：S3 stimulation is able to restore the intestinal movement after denervation （especially single haustrum and distal colon）,which promotes defecation.
