Background: Finasteride,an inhibitor of type 2 5α-reductase,inhibits conversion of testosterone to dihydrotestosterone,resulting in a decrease in serum and scalp dihydrotestosterone levels believed to be pathogenic i...Background: Finasteride,an inhibitor of type 2 5α-reductase,inhibits conversion of testosterone to dihydrotestosterone,resulting in a decrease in serum and scalp dihydrotestosterone levels believed to be pathogenic in androgenetic alopecia. Oral finasteride has been shown to be effective in the treatment of hair loss in men,while its efficacy in women has remained controversial. Methods: 5 postmenopausal women without clinical or laboratory signs of hyperandrogenism were given 2.5 or 5 mg/day oral finasteride for the treatment of pattern hair loss. Efficacy was evaluated by patient and investigator assessments,and review of photographs taken at baseline and at months 6,12 and 18 by an expert panel. Results: Finasteride treatment improved scalp hair by all evaluation techniques. The patients’self-assessment demonstrated that finasteride treatment decreased hair loss,increased hair growth and improved appearance of hair. These improvements were confirmed by investigator assessment and assessments of photographs. No adverse effects were noted. Conclusions: Oral finasteride in a dosage of 2.5 mg/day or more may be effective for the treatment of pattern hair loss in postmenopausal women in the absence of clinical or laboratory signs of hyperandrogenism.展开更多
Hyperandrogenism with hyperandrogenemia should be considered in those with sev ere acne of sudden onset or conspicuous male-pattern baldness with hairline rec ession, although the majority of female patients with acne...Hyperandrogenism with hyperandrogenemia should be considered in those with sev ere acne of sudden onset or conspicuous male-pattern baldness with hairline rec ession, although the majority of female patients with acne or androgenetic alope cia possess no endocrine diorder. Herein we describe on the contrary 2 young wom en with primary amenorrhea displaying prominent hyperandrogenemia but subtle cut aneous manifestation. The first one presenting vertical alopecia had an elevated level of serum dehydroepiandrosterone sulfate (>800 μg/dl)and was suspected to be a case of late-onset, non-classical adrenal hyperplasia. The second case w ith mild acne had a soaring serum level of total testosterone >9,000 ng/dl deriv ed from an androgen-secreting adrenal adenoma overexpressing steroidogenic acut e regulatory protein, P450 side-chain cleavage enzyme and aromatase. A careful patient history and a complete physical examination are mandatory in each indivi dual female case with acne or alopecia. The possibility of adrenal tumor should be explored in patients with escalated circulating testosterone.展开更多
文摘Background: Finasteride,an inhibitor of type 2 5α-reductase,inhibits conversion of testosterone to dihydrotestosterone,resulting in a decrease in serum and scalp dihydrotestosterone levels believed to be pathogenic in androgenetic alopecia. Oral finasteride has been shown to be effective in the treatment of hair loss in men,while its efficacy in women has remained controversial. Methods: 5 postmenopausal women without clinical or laboratory signs of hyperandrogenism were given 2.5 or 5 mg/day oral finasteride for the treatment of pattern hair loss. Efficacy was evaluated by patient and investigator assessments,and review of photographs taken at baseline and at months 6,12 and 18 by an expert panel. Results: Finasteride treatment improved scalp hair by all evaluation techniques. The patients’self-assessment demonstrated that finasteride treatment decreased hair loss,increased hair growth and improved appearance of hair. These improvements were confirmed by investigator assessment and assessments of photographs. No adverse effects were noted. Conclusions: Oral finasteride in a dosage of 2.5 mg/day or more may be effective for the treatment of pattern hair loss in postmenopausal women in the absence of clinical or laboratory signs of hyperandrogenism.
文摘Hyperandrogenism with hyperandrogenemia should be considered in those with sev ere acne of sudden onset or conspicuous male-pattern baldness with hairline rec ession, although the majority of female patients with acne or androgenetic alope cia possess no endocrine diorder. Herein we describe on the contrary 2 young wom en with primary amenorrhea displaying prominent hyperandrogenemia but subtle cut aneous manifestation. The first one presenting vertical alopecia had an elevated level of serum dehydroepiandrosterone sulfate (>800 μg/dl)and was suspected to be a case of late-onset, non-classical adrenal hyperplasia. The second case w ith mild acne had a soaring serum level of total testosterone >9,000 ng/dl deriv ed from an androgen-secreting adrenal adenoma overexpressing steroidogenic acut e regulatory protein, P450 side-chain cleavage enzyme and aromatase. A careful patient history and a complete physical examination are mandatory in each indivi dual female case with acne or alopecia. The possibility of adrenal tumor should be explored in patients with escalated circulating testosterone.
