We further study the kinetic behavior of the exchange-driven growth withbirth and death for the case of birth rate kernel being less than that of death based on themean-Geld theory. The symmetric exchange rate kernel ...We further study the kinetic behavior of the exchange-driven growth withbirth and death for the case of birth rate kernel being less than that of death based on themean-Geld theory. The symmetric exchange rate kernel is K(k,j) = K′(k,j) = Ikj~v, and the birth anddeath rates are proportional to the aggregate's size. The long time asymptotic behavior of theaggregate size distribution a_k(t) is found to obey a much unusual scaling law with an exponentiallygrowing scaling function Φ(x) = exp(x).展开更多
A thorough understanding of how proteins induce nanoparticle （NP） aggregation is crucial when designing in vitro and in vivo assays and interpreting experimental results. This knowledge is also crucial when developi...A thorough understanding of how proteins induce nanoparticle （NP） aggregation is crucial when designing in vitro and in vivo assays and interpreting experimental results. This knowledge is also crucial when developing nano-applications and formulation for drug delivery systems. In this study, we found that extraction of immunoglobulin G （IgG） from cow serum results in lower polystyrene NPs aggregation. Moreover, addition of isolated IgG or fibrinogen to fetal cow serum enhanced this aggregation, thus demonstrating that these factors are major drivers of NP aggregation in serum. Counter-intuitively, NP aggregation was inversely dependent on protein concentration; i.e., low protein concentrations induced large aggregates, whereas high protein concentrations induced small aggregates. Protein-induced NP aggregation and aggregate size were monitored by absorbance at 400 nm and dynamic light scattering, respectively. Here, we propose a mechanism behind the protein concentration dependent aggregation; this mechanism involves the effects of multiple protein interactions on the NP surface, surface area limitations, aggregation kinetics, and the influence of other serum proteins.展开更多
文摘We further study the kinetic behavior of the exchange-driven growth withbirth and death for the case of birth rate kernel being less than that of death based on themean-Geld theory. The symmetric exchange rate kernel is K(k,j) = K′(k,j) = Ikj~v, and the birth anddeath rates are proportional to the aggregate's size. The long time asymptotic behavior of theaggregate size distribution a_k(t) is found to obey a much unusual scaling law with an exponentiallygrowing scaling function Φ(x) = exp(x).
文摘A thorough understanding of how proteins induce nanoparticle （NP） aggregation is crucial when designing in vitro and in vivo assays and interpreting experimental results. This knowledge is also crucial when developing nano-applications and formulation for drug delivery systems. In this study, we found that extraction of immunoglobulin G （IgG） from cow serum results in lower polystyrene NPs aggregation. Moreover, addition of isolated IgG or fibrinogen to fetal cow serum enhanced this aggregation, thus demonstrating that these factors are major drivers of NP aggregation in serum. Counter-intuitively, NP aggregation was inversely dependent on protein concentration; i.e., low protein concentrations induced large aggregates, whereas high protein concentrations induced small aggregates. Protein-induced NP aggregation and aggregate size were monitored by absorbance at 400 nm and dynamic light scattering, respectively. Here, we propose a mechanism behind the protein concentration dependent aggregation; this mechanism involves the effects of multiple protein interactions on the NP surface, surface area limitations, aggregation kinetics, and the influence of other serum proteins.
