Objective: To observe the clinical effect of electroacupuncture in treating perimenopause syndrome (PMS) and explore its possible action mechanism. Methods: All of 110 cases with PMS were randomized into group A [...Objective: To observe the clinical effect of electroacupuncture in treating perimenopause syndrome (PMS) and explore its possible action mechanism. Methods: All of 110 cases with PMS were randomized into group A [Guanyuan (CV 4) and Sanyinjiao (SP 6)] and group B [Neiguan (PC 6) and Zusanli (ST 36)], 55 cases in each. After 4-week treatments, the Kupperman Menopausal Index (KMI) was adopted to evaluate the therapeutic effect. Estradiol (E2), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were assayed respectively before and after treatments. Results: The KMI decreased by 52.6% in group A, versus 47.4% in group B. The total effective rate was 93.6% in group A, versus 85.7% in group B, and the difference was not significant (P〈0.05). The content of E2 both increased in the two groups after 4-week treatments (P〈0.05); the contents of FSH and LH dropped but without statistical difference (P〈0.05). Conclusion: Both of the two acupoints groups can significantly lower KMI, and effectively increase the contents of E2 in patients with PMS展开更多
文摘Objective: To observe the clinical effect of electroacupuncture in treating perimenopause syndrome (PMS) and explore its possible action mechanism. Methods: All of 110 cases with PMS were randomized into group A [Guanyuan (CV 4) and Sanyinjiao (SP 6)] and group B [Neiguan (PC 6) and Zusanli (ST 36)], 55 cases in each. After 4-week treatments, the Kupperman Menopausal Index (KMI) was adopted to evaluate the therapeutic effect. Estradiol (E2), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were assayed respectively before and after treatments. Results: The KMI decreased by 52.6% in group A, versus 47.4% in group B. The total effective rate was 93.6% in group A, versus 85.7% in group B, and the difference was not significant (P〈0.05). The content of E2 both increased in the two groups after 4-week treatments (P〈0.05); the contents of FSH and LH dropped but without statistical difference (P〈0.05). Conclusion: Both of the two acupoints groups can significantly lower KMI, and effectively increase the contents of E2 in patients with PMS