复方炔诺孕酮缓释微囊注射液的研究

采用复凝聚法制备复方避孕药［左炔诺孕酮（ＬＮＧ）和雌二醇戊酸酯（ＥＶ）之重量比为５：３］缓释微囊肌肉注射液。囊径１０～６０μｍ的占８２．６％，室温贮存５年后，囊形、囊径分布和含量几乎无变化。体外以５０％乙醇液或含５％乙醇的ｐＨ７．４磷酸盐缓冲液作释放介质时，微囊注射液释放ＬＮＧ均服从零级释放规律，ｋ＿ｒ分别为７２μｇ／ｈ、３４μｇ／ｄ，ｔ＿（５０）为１０．４ｈ、３２．３ｄ，释放量对时间的线性关系良好，与破囊后的注射液相比有极显著差异。微囊注射液具有明显的缓释作用。

激素、维生素及相关药物——Bayer向美国申请Qlaira的NDA

Bayer公司已向美国申请其基于雌二醇的新的口服避孕药Qlaira（雌二醇戊酸酯／地诺孕素）（I），用于口服避孕及治疗大量及／或持久月经出血适应症的NDA。

The Change of Serum Prolactin Level after Multiple Injection of Norethisterone Enanthate and Estradiol Valerate

Sixteen healthy fertile women were recruited in a longitudinal study,and monthly given an injectable containing Norethisterone Enanthate (NET-EN) 50mg and Estradiol Valerate (EV) 5mg on the 5th day of menstrual cycle for 12 months.Blood samples were collected from each subject prior to and on day 1,7,21 after the 1st,6th and 12th injection.Serum Prolactin (PRL) level was measured by RIA.The PRL level of each cycle in almost every individual showed an obvious increase after injection of NET-EN/EV,followed by a gradual decrease from the middle of cycle length,then returned to its basal level.The profile of PRL level for each treated cycle could be well described by polynomial equation.The results indicate that there is no obvious effects and constant increase tendency on PRL level after long-term (1 year) injections of NET-EN 50mg/EV 5mg in healthy women.