需要治疗的病例数(number needed to treat,NNT)是近年来国际上用于评价临床疗效的一个简单而有效的指标,它通过对分类变量数据绝对危险度减低这一指标的计算,能够客观评价干预措施的临床疗效。然而,目前国内对于这一指标临床应用的介...需要治疗的病例数(number needed to treat,NNT)是近年来国际上用于评价临床疗效的一个简单而有效的指标,它通过对分类变量数据绝对危险度减低这一指标的计算,能够客观评价干预措施的临床疗效。然而,目前国内对于这一指标临床应用的介绍尚未见报道。本文通过已发表的临床研究文献的实例,解释NNT这一指标及其95%可信区间的计算,并通过其相关名词的解释、荟萃分析的方法等方面说明该指标的具体应用。展开更多
目的应用"需要治疗的病例数(Number Needed to be Treated,NNT)"指标对慢性浅表性胃炎(中医脾阳虚证型)的中西药治疗进行疗效评价。方法将符合标准的慢性浅表性胃炎(中医脾阳虚证型)病例分两组即中药组和西药组,分别予以中成...目的应用"需要治疗的病例数(Number Needed to be Treated,NNT)"指标对慢性浅表性胃炎(中医脾阳虚证型)的中西药治疗进行疗效评价。方法将符合标准的慢性浅表性胃炎(中医脾阳虚证型)病例分两组即中药组和西药组,分别予以中成药附子理中丸和西药常规治疗,以"反酸"为治疗时间终点结局事件,计算NNT及其相关指标。结果 NNT=8。每治疗8例慢性浅表性胃炎患者,中药组要比西药组多预防1例反酸事件的发生,但中药组和西药组的治疗效果之间差异无显著性。结论 NNT作为疗效比较和评价的指标之一,具有直观明了的特点,容易被临床医生理解,在循证医学和临床流行病学领域值得推广应用。展开更多
The recent explosion of biological data and the concomitant proliferation of distributed databases make it challenging for biologists and bioinformaticians to discover the best data resources for their needs, and the ...The recent explosion of biological data and the concomitant proliferation of distributed databases make it challenging for biologists and bioinformaticians to discover the best data resources for their needs, and the most efficient way to access and use them For the biologist, running bioinformatics analyses involve a time-consuming management of data and tools. Users need support to organize their work, retrieve parameters and reproduce their analyses. They also need to be able to combine their analytic tools using a safe data flow software mechanism. Finally we have designed a system, Bioinfo-Portal, to provide a flexible and usable web environment for defining and running bioinformatics analyses. It embeds simple yet powerful data management features that allow the user to reproduce analyses and to combine tools using an adobe flex tool. Bioinfo-Portal can also act as a front end to provide a unified view of already-existing collections of bioinformatics resources. Users can analyze genomic and proteomic data by using the tools that has been integrated in the portal (tools for alignments, dotplots, motif detection, domain analysis, profile searching and tertiary structure prediction). The sequences that user obtained from portal's nucleotide and protein databases are easily analyzed by the portal tools on the same interface in no time. User can also take benefit from the animations.展开更多
文摘需要治疗的病例数(number needed to treat,NNT)是近年来国际上用于评价临床疗效的一个简单而有效的指标,它通过对分类变量数据绝对危险度减低这一指标的计算,能够客观评价干预措施的临床疗效。然而,目前国内对于这一指标临床应用的介绍尚未见报道。本文通过已发表的临床研究文献的实例,解释NNT这一指标及其95%可信区间的计算,并通过其相关名词的解释、荟萃分析的方法等方面说明该指标的具体应用。
文摘目的应用"需要治疗的病例数(Number Needed to be Treated,NNT)"指标对慢性浅表性胃炎(中医脾阳虚证型)的中西药治疗进行疗效评价。方法将符合标准的慢性浅表性胃炎(中医脾阳虚证型)病例分两组即中药组和西药组,分别予以中成药附子理中丸和西药常规治疗,以"反酸"为治疗时间终点结局事件,计算NNT及其相关指标。结果 NNT=8。每治疗8例慢性浅表性胃炎患者,中药组要比西药组多预防1例反酸事件的发生,但中药组和西药组的治疗效果之间差异无显著性。结论 NNT作为疗效比较和评价的指标之一,具有直观明了的特点,容易被临床医生理解,在循证医学和临床流行病学领域值得推广应用。
文摘The recent explosion of biological data and the concomitant proliferation of distributed databases make it challenging for biologists and bioinformaticians to discover the best data resources for their needs, and the most efficient way to access and use them For the biologist, running bioinformatics analyses involve a time-consuming management of data and tools. Users need support to organize their work, retrieve parameters and reproduce their analyses. They also need to be able to combine their analytic tools using a safe data flow software mechanism. Finally we have designed a system, Bioinfo-Portal, to provide a flexible and usable web environment for defining and running bioinformatics analyses. It embeds simple yet powerful data management features that allow the user to reproduce analyses and to combine tools using an adobe flex tool. Bioinfo-Portal can also act as a front end to provide a unified view of already-existing collections of bioinformatics resources. Users can analyze genomic and proteomic data by using the tools that has been integrated in the portal (tools for alignments, dotplots, motif detection, domain analysis, profile searching and tertiary structure prediction). The sequences that user obtained from portal's nucleotide and protein databases are easily analyzed by the portal tools on the same interface in no time. User can also take benefit from the animations.