Mycophenolate acid is a novel immunosuppressive drug. Its target of action is the isomerⅡof inosine 5’-monophosphate dehydrogenase(IMPDH). It inhibits de nove purine synthesis and also decreases expression of adhesi...Mycophenolate acid is a novel immunosuppressive drug. Its target of action is the isomerⅡof inosine 5’-monophosphate dehydrogenase(IMPDH). It inhibits de nove purine synthesis and also decreases expression of adhesive molecule. It inhibits selectively the proliferation of lymphocyte, so that it has strong immunosuppressive effects on various rejections to allograft or xenograft, and on autoimmune diseases, and has the features of higher potency and lower toxicity.[展开更多
Phenazine antibiotics phenazine-l-carboxylic acid （PCA） and l-hydroxyphenazine （1-OH-PHZ） were purified from culture broth and mycelia ofStreptomyces griseoluteus P510, Both PCA and 1 -OH-PHZ exhibit strong antifu...Phenazine antibiotics phenazine-l-carboxylic acid （PCA） and l-hydroxyphenazine （1-OH-PHZ） were purified from culture broth and mycelia ofStreptomyces griseoluteus P510, Both PCA and 1 -OH-PHZ exhibit strong antifun- gal activity against six plant pathogens, especially Fusarium oxysporium, with minimal inhibition concentrations less than I and 2/ag, ml- 1 for PCA and 1-OH-PHZ, respectively, The presence of PCA and 1 -OH-PHZ indicates that S. griseoluteus PSlO can be used as a potential source of pesticides,展开更多
文摘Mycophenolate acid is a novel immunosuppressive drug. Its target of action is the isomerⅡof inosine 5’-monophosphate dehydrogenase(IMPDH). It inhibits de nove purine synthesis and also decreases expression of adhesive molecule. It inhibits selectively the proliferation of lymphocyte, so that it has strong immunosuppressive effects on various rejections to allograft or xenograft, and on autoimmune diseases, and has the features of higher potency and lower toxicity.[
基金Supported by the National High Technology Research and Development Program of China(2012AA022107)the National Basic Research Program of China(2012CB722105)+1 种基金the National Natural Science Foundation of China(20706037)the Ph.D.Programs Foundation of Ministry of Education of China(20090073110052)
文摘Phenazine antibiotics phenazine-l-carboxylic acid （PCA） and l-hydroxyphenazine （1-OH-PHZ） were purified from culture broth and mycelia ofStreptomyces griseoluteus P510, Both PCA and 1 -OH-PHZ exhibit strong antifun- gal activity against six plant pathogens, especially Fusarium oxysporium, with minimal inhibition concentrations less than I and 2/ag, ml- 1 for PCA and 1-OH-PHZ, respectively, The presence of PCA and 1 -OH-PHZ indicates that S. griseoluteus PSlO can be used as a potential source of pesticides,
