目的探究持续性高眼压性青光眼患者采用抗青光眼手术的治疗效果。方法选取本院2012年3月—2017年3月的45例接受手术治疗的青光眼患者,根据用药后眼压情况分为两组,观察组22例患者为用药后眼压超过40 mm Hg,即持续性高眼压,对照组23例患...目的探究持续性高眼压性青光眼患者采用抗青光眼手术的治疗效果。方法选取本院2012年3月—2017年3月的45例接受手术治疗的青光眼患者,根据用药后眼压情况分为两组,观察组22例患者为用药后眼压超过40 mm Hg,即持续性高眼压,对照组23例患者为用药后眼压不足40 mm Hg。并对两组患者的治疗总有效率、滤过泡分型与并发症发生率情况予以对比。结果两组患者的总有效率,差异无统计学意义(P>0.05);两组患者滤过泡分型对比,差异无统计学意义(P>0.05);观察组患者并发症发生率为50.00%,高于对照组的17.39%,差异有统计学意义(P<0.05)。结论持续性高眼压青光眼患者采用抗青光眼手术的治疗效果与普通性青光眼的治疗效果类似,但持续性高眼压患者的并发症发生率较高,所以,需要合理选择手术方式对持续性高眼压青光眼进行治疗。展开更多
This study was conducted to elucidate the potential key candidate genes and pathways in role of astrocyte involved in glaucoma with ocular hypertension.Methods Expression profiles GSE2378 and GSE758 including 27 react...This study was conducted to elucidate the potential key candidate genes and pathways in role of astrocyte involved in glaucoma with ocular hypertension.Methods Expression profiles GSE2378 and GSE758 including 27 reactive optic nerve head astrocytes(ONHAs)by hypertensions and 26 normal controls,were integrated and deeply analyzed.Differentially expressed genes(DEGs)were sorted and candidate genes and pathways enrichment were analyzed.DEGs-associated protein-protein interaction network(PPI)was performed.Results A total of 119 consistently expressed genes were identified from 281 commonly changed DEGs,including 68 up-regulated genes and 51 down-regulated genes.PPI network complex filtered 75 DEGs(43 up-regulated and 32 down-regulated genes)of the 119 consistently altered DEGs and developed 117 edges,and 10 hub genes were identified.The most significant 3 modules were filtered from PPI,pathway enrichment analysis showed that module 1 was associated with extracellular exosome.Module 2 was mainly associated with antibody-dependent cellular cytotoxicity(ADCC)and module 3 was mainly associated with Hippo signaling pathway.Conclusion Taken above,using integrated bioinformatical analysis,we have identified DEGs candidate genes and pathways in role of astrocyte involved in glaucoma with ocular hypertension,which could improve our understanding of the cause and underlying molecular events,and these candidate genes and pathways could be therapeutic targets for glaucoma.展开更多
文摘目的探究持续性高眼压性青光眼患者采用抗青光眼手术的治疗效果。方法选取本院2012年3月—2017年3月的45例接受手术治疗的青光眼患者,根据用药后眼压情况分为两组,观察组22例患者为用药后眼压超过40 mm Hg,即持续性高眼压,对照组23例患者为用药后眼压不足40 mm Hg。并对两组患者的治疗总有效率、滤过泡分型与并发症发生率情况予以对比。结果两组患者的总有效率,差异无统计学意义(P>0.05);两组患者滤过泡分型对比,差异无统计学意义(P>0.05);观察组患者并发症发生率为50.00%,高于对照组的17.39%,差异有统计学意义(P<0.05)。结论持续性高眼压青光眼患者采用抗青光眼手术的治疗效果与普通性青光眼的治疗效果类似,但持续性高眼压患者的并发症发生率较高,所以,需要合理选择手术方式对持续性高眼压青光眼进行治疗。
基金support from the China National Natural Science Foundation Funding Project(NO.81804150)Hunan University of Chinese Medicine,National Key Discipline of TCM Diagnostics Foundation Funding Project(No.2015ZYZD02)+5 种基金The Domestic First-class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese MedicineHunan Provincial Department of Education Innovation Platform Open Fund Project(16K065)Chinese Medicine Key Laboratory of Prevention and Treatment of Disease in Hunan Province(2017TP1018)Changsha Science and Technology Plan Project(KC1704005)Hunan Engineering Technology Research Center for the Prevention and Treatment of Otorhinolaryngologic Diseases and Protection of Visual Function with Chinese MedicineHunan Provincial Research Innovation Project for Graduate students(CX2017B426)
文摘This study was conducted to elucidate the potential key candidate genes and pathways in role of astrocyte involved in glaucoma with ocular hypertension.Methods Expression profiles GSE2378 and GSE758 including 27 reactive optic nerve head astrocytes(ONHAs)by hypertensions and 26 normal controls,were integrated and deeply analyzed.Differentially expressed genes(DEGs)were sorted and candidate genes and pathways enrichment were analyzed.DEGs-associated protein-protein interaction network(PPI)was performed.Results A total of 119 consistently expressed genes were identified from 281 commonly changed DEGs,including 68 up-regulated genes and 51 down-regulated genes.PPI network complex filtered 75 DEGs(43 up-regulated and 32 down-regulated genes)of the 119 consistently altered DEGs and developed 117 edges,and 10 hub genes were identified.The most significant 3 modules were filtered from PPI,pathway enrichment analysis showed that module 1 was associated with extracellular exosome.Module 2 was mainly associated with antibody-dependent cellular cytotoxicity(ADCC)and module 3 was mainly associated with Hippo signaling pathway.Conclusion Taken above,using integrated bioinformatical analysis,we have identified DEGs candidate genes and pathways in role of astrocyte involved in glaucoma with ocular hypertension,which could improve our understanding of the cause and underlying molecular events,and these candidate genes and pathways could be therapeutic targets for glaucoma.
