目的观察当归止痒方治疗成人血虚风燥型特应性皮炎的临床疗效及安全性。方法2021年7月—2022年1月该院皮肤科就诊的成人特应性皮炎患者中纳入符合血虚风燥证型患者,共76例。随机分入试验组和对照组,每组38例。对照组口服润燥止痒胶囊,...目的观察当归止痒方治疗成人血虚风燥型特应性皮炎的临床疗效及安全性。方法2021年7月—2022年1月该院皮肤科就诊的成人特应性皮炎患者中纳入符合血虚风燥证型患者,共76例。随机分入试验组和对照组,每组38例。对照组口服润燥止痒胶囊,试验组口服当归止痒方,两组皆外用纽强倍润型润肤露。治疗8周,对两组瘙痒面积及严重度指数(Eczema Area and Severity Index,EASI)评分、患者主观湿疹评分(Patient-Oriented Eczema Measure,POEM)评分、皮肤病患者生活质量量表(Dermatology Life Quality Index,DLQI)评分、研究者整体评估(Investigator′s Global Assessment,IGA)评分、瘙痒数值评分(Itch-Numerical Rating Scores,Itch-NRS)评分、血清总IgE、血清嗜酸性粒细胞计数(EOS)、中医症状积分及安全性指标等方面进行评价。结果(1)试验组总有效率91.89%(34/37),高于对照组61.76%(21/34)(P<0.05);试验组中医症状积分改善有效率86.49%(32/37),高于对照组47.05%(16/34)(P<0.05)。(2)试验组EASI评分(17.81±6.06)分、POEM评分(11.19±3.76)分、DLQI评分(14.16±3.03)分、IGA评分(2.24±0.68)分、Itch-NRS评分(4.73±1.37)分的下降均较对照组明显(P均<0.05)。(3)两组血清EOS水平在治疗后均有所下降(P<0.05);血清IgE水平两组均无明显干预效果。结论当归止痒方治疗成人血虚风燥型特应性皮炎的临床疗效显著优于润燥止痒胶囊,没有使用首乌的情况下也能够有效改善患者瘙痒症状,提高患者生活质量,同时能够改善患者血虚、便秘、皮肤干燥、瘙痒等中医伴随症状,且没有不良反应发生。展开更多
Background: Atopic dermatitis (AD) is common in the population, and studies have shown that the disease is on the ncrease. Studies based on hospital records reflect selected populations and may miss less severe cases ...Background: Atopic dermatitis (AD) is common in the population, and studies have shown that the disease is on the ncrease. Studies based on hospital records reflect selected populations and may miss less severe cases of AD, and the use of self-reported questionnaires has the drawback of recall bias. Objectives: To investigate some possible factors influencing recall bias when questionnaires are used to establish the prevalence of childhood eczema in an adult population. Methods: A questionnaire regarding past and present eczema was sent to 557 cases (with signs suggesting the diagnosis AD) and 554 matched controls (subjects lacking signs of AD) born during 1960-1969 and identified in school health medical records. Cases and controls were aged 31-42 years at the time of the study and 70.5%returned the questionnaire. Results: Of 403 cases, 29%did not report childhood eczema in the questionnaire. There was a difference between those who did recall their childhood AD (remembering group, RG), and those who did not (forgetful group, FG) in who had documented the diagnostic signs in the school health records. In the RG the signs were reported by both parents and school health personnel in 51%of cases, and in the FG this was true of only 16%. The RG had a higher prevalence of eczema after 15 years of age and of hand eczema. The RG also reported more visits to physicians after the age of 15 years and more time taken as sick leave due to eczema. Conclusions: Several factors influence how well people remember their AD in childhood. These factors include disease activity in adult life, disease severity, and who noticed the eczema in childhood.展开更多
文摘目的观察当归止痒方治疗成人血虚风燥型特应性皮炎的临床疗效及安全性。方法2021年7月—2022年1月该院皮肤科就诊的成人特应性皮炎患者中纳入符合血虚风燥证型患者,共76例。随机分入试验组和对照组,每组38例。对照组口服润燥止痒胶囊,试验组口服当归止痒方,两组皆外用纽强倍润型润肤露。治疗8周,对两组瘙痒面积及严重度指数(Eczema Area and Severity Index,EASI)评分、患者主观湿疹评分(Patient-Oriented Eczema Measure,POEM)评分、皮肤病患者生活质量量表(Dermatology Life Quality Index,DLQI)评分、研究者整体评估(Investigator′s Global Assessment,IGA)评分、瘙痒数值评分(Itch-Numerical Rating Scores,Itch-NRS)评分、血清总IgE、血清嗜酸性粒细胞计数(EOS)、中医症状积分及安全性指标等方面进行评价。结果(1)试验组总有效率91.89%(34/37),高于对照组61.76%(21/34)(P<0.05);试验组中医症状积分改善有效率86.49%(32/37),高于对照组47.05%(16/34)(P<0.05)。(2)试验组EASI评分(17.81±6.06)分、POEM评分(11.19±3.76)分、DLQI评分(14.16±3.03)分、IGA评分(2.24±0.68)分、Itch-NRS评分(4.73±1.37)分的下降均较对照组明显(P均<0.05)。(3)两组血清EOS水平在治疗后均有所下降(P<0.05);血清IgE水平两组均无明显干预效果。结论当归止痒方治疗成人血虚风燥型特应性皮炎的临床疗效显著优于润燥止痒胶囊,没有使用首乌的情况下也能够有效改善患者瘙痒症状,提高患者生活质量,同时能够改善患者血虚、便秘、皮肤干燥、瘙痒等中医伴随症状,且没有不良反应发生。
文摘Background: Atopic dermatitis (AD) is common in the population, and studies have shown that the disease is on the ncrease. Studies based on hospital records reflect selected populations and may miss less severe cases of AD, and the use of self-reported questionnaires has the drawback of recall bias. Objectives: To investigate some possible factors influencing recall bias when questionnaires are used to establish the prevalence of childhood eczema in an adult population. Methods: A questionnaire regarding past and present eczema was sent to 557 cases (with signs suggesting the diagnosis AD) and 554 matched controls (subjects lacking signs of AD) born during 1960-1969 and identified in school health medical records. Cases and controls were aged 31-42 years at the time of the study and 70.5%returned the questionnaire. Results: Of 403 cases, 29%did not report childhood eczema in the questionnaire. There was a difference between those who did recall their childhood AD (remembering group, RG), and those who did not (forgetful group, FG) in who had documented the diagnostic signs in the school health records. In the RG the signs were reported by both parents and school health personnel in 51%of cases, and in the FG this was true of only 16%. The RG had a higher prevalence of eczema after 15 years of age and of hand eczema. The RG also reported more visits to physicians after the age of 15 years and more time taken as sick leave due to eczema. Conclusions: Several factors influence how well people remember their AD in childhood. These factors include disease activity in adult life, disease severity, and who noticed the eczema in childhood.
