AIM： To compare the effectiveness of triple, standard quadruple and ampicillin-sulbactam-based quadruple therapies for Hpylori eradication in a comparative three-armed randomized clinical trial. METHODS： A total of ...AIM： To compare the effectiveness of triple, standard quadruple and ampicillin-sulbactam-based quadruple therapies for Hpylori eradication in a comparative three-armed randomized clinical trial. METHODS： A total of 360 H pylori-positive patients suffering from dyspepsia and aging 24-79 years with a median age of 42 years were enrolled in the study and randomly allocated into the following three groups： group A （n = 120） received a standard 1-wk triple therapy （20 mg omeprazole b.i.d., 1000 mg amoxicillin b.i.d., 500 mg clarithromycin b.i.d.）, group B （n = 120） received a 10-d standard quadruple therapy （20 mg omeprazole b.i.d., 1000 mg amoxicillin b.i.d., 240 mg colloidal bismuth subcitrate b.i.d., and 500 mg metronidazole b.i.d.）, group C （n = 120） received the new protocol, i.e. 375 mg sultamicillin （225 mg ampicillin plus 150 mg sulbactam） b.i.d. （before breakfast and dinner）, instead of amoxicillin in the standard quadruple therapy for the same duration. Chi-square test with the consideration of P 〈 0.05 as significant was used to compare the eradication rates by intention-to-treat and per-protocol analyses in the three groups.RESULTS： The per-protocol eradication rate was 91.81% （101 patients from a total of 110） in group A, 85.84% （97 patients from a total of 113） in group B, and 92.85% （104 patients from a total of 112） in group C. The intention-to-treat eradication rate was 84.17% in group A, 80.83% in group B, and 86.67% in group C. The new protocol yielded the highest eradication rates by both per-protocol and intention-to-treat analyses followed by the standard triple and quadruple regimens, respectively. However, the differences were not statistically significant between the three groups. CONCLUSION： The results of this study provide further support for the equivalence of triple and quadruple therapies in terms of effectiveness, compliance and sideeffect profile when administered as first-line treatment for H pylori infection. Moreover, the new protocol using ampicillin-sulbactam instead of amoxicillin in the quadruple regimen is a suitable first-line alternative to be used in regions with amoxicillin-resistant Hpylori strains.展开更多
The morphology and infraciliature of a new marine colepid ciliate, A＇pocoleps magnus gen. nov., spec. nov., are de- scribed based on living observations and silver impregnations. The new genus Apocoleps is characteri...The morphology and infraciliature of a new marine colepid ciliate, A＇pocoleps magnus gen. nov., spec. nov., are de- scribed based on living observations and silver impregnations. The new genus Apocoleps is characterized by having 8 （vs. 6 in most other related genera） armour tiers, spines at both ends of the cell, 3 adoral organelles and plates with 4 reniform uni-windows. Apo- coleps magnus spec. nov. is defined by the following features： body elongated and slightly curved, about 100-120p.mx 3545 lam in vivo; anterior tertiary tier plate with four uni-windows, most secondary and main tier plates with four uni-windows, posterior tertiary tier plate with two uni-windows; left plate margin slightly serrated; on average 23 transverse and 22 longitudinal ciliary rows; one terminal contractile vacuole; marine habitat.展开更多
Eczema is a kind of very common dermatopathy. The cases with a long course of illness and hard to be cured are termed as stubborn eczema. We have obtained good results in its treatment since 1995 with the Chu Shi Tan...Eczema is a kind of very common dermatopathy. The cases with a long course of illness and hard to be cured are termed as stubborn eczema. We have obtained good results in its treatment since 1995 with the Chu Shi Tang (除湿汤Dampness-Clearing Decoction) for oral intake and the Fu Fang Ku Shen Xi Ye (复方苦参洗液) for topical application. The following is a clinical report for treating 56 patients with stubborn eczema.展开更多
Acne is an inflammatory disease often affecting the boys and girls at the pubescent age, with a tendency of affecting the females aged 30-45 years. We have treated 56 cases of acne by auricular needle-embedding wi... Acne is an inflammatory disease often affecting the boys and girls at the pubescent age, with a tendency of affecting the females aged 30-45 years. We have treated 56 cases of acne by auricular needle-embedding with satisfactory therapeutic results as reported in the following.……展开更多
In this paper, the changes in temperature and precipitation extremes over the next 20-30 years (2021-2050) in relative to the present day (1986-2005) under the Intergovernmental Panel on Climate Change (IPCC) Special ...In this paper, the changes in temperature and precipitation extremes over the next 20-30 years (2021-2050) in relative to the present day (1986-2005) under the Intergovernmental Panel on Climate Change (IPCC) Special Report on Emissions Scenarios (SRES) A1B scenario are analyzed based on a high-resolution climate change simulation performed by a regional climate model (the Abdus Salam International Center for Theoretical Physics (ICTP) RegCM3). The extreme indices of summer days (SU), frost days (FD), and growing season length (GSL) for temperature and simple daily intensity index (SDII), number of days with precipitation ≥10 mm d-1 (R10), and consecutive dry days (CDD) for precipitation are used as the indicators of the extremes. The results show that the indices simulated by RegCM3 in the present day show good agreement with the observed. A general increase in SU, a decrease in FD, and an increase in GSL are found to occur in the next 20-30 years over China. A general increase in SDII, an increase in R10 over western China, and a decrease in R10 in north, northeast, and central China are simulated by the model. Changes in CDD are characterized by a decrease in the north and an increase in the south and the Tibetan Plateau.展开更多
文摘AIM： To compare the effectiveness of triple, standard quadruple and ampicillin-sulbactam-based quadruple therapies for Hpylori eradication in a comparative three-armed randomized clinical trial. METHODS： A total of 360 H pylori-positive patients suffering from dyspepsia and aging 24-79 years with a median age of 42 years were enrolled in the study and randomly allocated into the following three groups： group A （n = 120） received a standard 1-wk triple therapy （20 mg omeprazole b.i.d., 1000 mg amoxicillin b.i.d., 500 mg clarithromycin b.i.d.）, group B （n = 120） received a 10-d standard quadruple therapy （20 mg omeprazole b.i.d., 1000 mg amoxicillin b.i.d., 240 mg colloidal bismuth subcitrate b.i.d., and 500 mg metronidazole b.i.d.）, group C （n = 120） received the new protocol, i.e. 375 mg sultamicillin （225 mg ampicillin plus 150 mg sulbactam） b.i.d. （before breakfast and dinner）, instead of amoxicillin in the standard quadruple therapy for the same duration. Chi-square test with the consideration of P 〈 0.05 as significant was used to compare the eradication rates by intention-to-treat and per-protocol analyses in the three groups.RESULTS： The per-protocol eradication rate was 91.81% （101 patients from a total of 110） in group A, 85.84% （97 patients from a total of 113） in group B, and 92.85% （104 patients from a total of 112） in group C. The intention-to-treat eradication rate was 84.17% in group A, 80.83% in group B, and 86.67% in group C. The new protocol yielded the highest eradication rates by both per-protocol and intention-to-treat analyses followed by the standard triple and quadruple regimens, respectively. However, the differences were not statistically significant between the three groups. CONCLUSION： The results of this study provide further support for the equivalence of triple and quadruple therapies in terms of effectiveness, compliance and sideeffect profile when administered as first-line treatment for H pylori infection. Moreover, the new protocol using ampicillin-sulbactam instead of amoxicillin in the quadruple regimen is a suitable first-line alternative to be used in regions with amoxicillin-resistant Hpylori strains.
基金supported by ‘the Natural Science Foundation of China’ (Project No. 30870264)the Darwin Initiative Programme (Project No. 14-015)
文摘The morphology and infraciliature of a new marine colepid ciliate, A＇pocoleps magnus gen. nov., spec. nov., are de- scribed based on living observations and silver impregnations. The new genus Apocoleps is characterized by having 8 （vs. 6 in most other related genera） armour tiers, spines at both ends of the cell, 3 adoral organelles and plates with 4 reniform uni-windows. Apo- coleps magnus spec. nov. is defined by the following features： body elongated and slightly curved, about 100-120p.mx 3545 lam in vivo; anterior tertiary tier plate with four uni-windows, most secondary and main tier plates with four uni-windows, posterior tertiary tier plate with two uni-windows; left plate margin slightly serrated; on average 23 transverse and 22 longitudinal ciliary rows; one terminal contractile vacuole; marine habitat.
文摘Eczema is a kind of very common dermatopathy. The cases with a long course of illness and hard to be cured are termed as stubborn eczema. We have obtained good results in its treatment since 1995 with the Chu Shi Tang (除湿汤Dampness-Clearing Decoction) for oral intake and the Fu Fang Ku Shen Xi Ye (复方苦参洗液) for topical application. The following is a clinical report for treating 56 patients with stubborn eczema.
文摘 Acne is an inflammatory disease often affecting the boys and girls at the pubescent age, with a tendency of affecting the females aged 30-45 years. We have treated 56 cases of acne by auricular needle-embedding with satisfactory therapeutic results as reported in the following.……
基金supported by the National Basic Research Program of China(Grant No.2009CB421407)the China-UK-Swiss Adapting to Climate Change in China Project (ACCC)-Climate Science
文摘In this paper, the changes in temperature and precipitation extremes over the next 20-30 years (2021-2050) in relative to the present day (1986-2005) under the Intergovernmental Panel on Climate Change (IPCC) Special Report on Emissions Scenarios (SRES) A1B scenario are analyzed based on a high-resolution climate change simulation performed by a regional climate model (the Abdus Salam International Center for Theoretical Physics (ICTP) RegCM3). The extreme indices of summer days (SU), frost days (FD), and growing season length (GSL) for temperature and simple daily intensity index (SDII), number of days with precipitation ≥10 mm d-1 (R10), and consecutive dry days (CDD) for precipitation are used as the indicators of the extremes. The results show that the indices simulated by RegCM3 in the present day show good agreement with the observed. A general increase in SU, a decrease in FD, and an increase in GSL are found to occur in the next 20-30 years over China. A general increase in SDII, an increase in R10 over western China, and a decrease in R10 in north, northeast, and central China are simulated by the model. Changes in CDD are characterized by a decrease in the north and an increase in the south and the Tibetan Plateau.
