Objective The resting-state functional magnetic resonance imaging(rs-f MRI)method was used to observe brain activity and its functional connection upon electroacupuncture stimulation at bilateral uterine acupoints(EX-...Objective The resting-state functional magnetic resonance imaging(rs-f MRI)method was used to observe brain activity and its functional connection upon electroacupuncture stimulation at bilateral uterine acupoints(EX-CA1),as well as to investigate the mechanism of acupuncture in the treatment of gynecological diseases.Methods Twenty-two healthy female subjects were stimulated by electroacupuncture at bilateral uterine acupoints;rs-f MRI data of the brain were acquired and standardized.Degree centrality(DC),amplitude of low-frequency fluctuation(ALFF),and regional homogeneity(ReHo)were used to analyze local spontaneous brain activity via acupuncture.An independent component analysis was used to evaluate the functional connectivity of the resting brain networks after acupuncture.Results Analytical results showed that the neural activity intensity of the precuneus lobe,orbitofrontal cortex,lingual gyrus,amygdala,and posterior central gyrus decreased after acupuncture(voxel P<0.001,cluster P<0.05).Functional connectivity analysis revealed weakened auditory and right frontal-parietal networks(voxel P<0.001,cluster P<0.05),enhanced visual network(voxel P<0.001,cluster P<0.05),and synergistic auditory network and hypothalamic-pituitary system.Conclusion Significant differences in neural activity and functional connectivity in specific brain regions were observed after acupuncture intervention at uterine acupoints;the hypothalamic-pituitary system also showed various active states in different brain regions.It is speculated that the effective mechanism of acupuncture at uterine acupoints is related to the regulation of reproductive hormones,emotional changes,and somatic sensations.Therefore,the methods used in this study could clarify the neural mechanism of uterine-point acupuncture in the treatment of gynecological diseases and may serve as a reference for other studies pertaining to acupuncture.展开更多
Y2001-62866-83 0118973电信管理网络中2维模拟:系统方法=Two-dimension-al modeling in TMN:a systems approach[会,英]/Liang,Y.& Lanman,M.//2000 International Confer-ence on Communication Technology Proceedings Vol.Ⅰof ...Y2001-62866-83 0118973电信管理网络中2维模拟:系统方法=Two-dimension-al modeling in TMN:a systems approach[会,英]/Liang,Y.& Lanman,M.//2000 International Confer-ence on Communication Technology Proceedings Vol.Ⅰof Ⅱ.—83～90(HC)基于分布目标技术的实现,本文提出 TMN 的2维模拟方法.此系统方法的关键理解就是依据 TMN中面向资源的信息(数据)目标分离计算接口的静态连接,并且能够强化计算目标中的计算接口,在运行时间内动态连接,这样用所提出模拟方法获得有效开放扩展的 TMN 结构,满足用户对快速服务产生和布置。展开更多
The XFEM(extended finite element method) has a lot of advantages over other numerical methods to resolve discontinuities across quasi-static interfaces due to the jump in fluidic parameters or surface tension.However,...The XFEM(extended finite element method) has a lot of advantages over other numerical methods to resolve discontinuities across quasi-static interfaces due to the jump in fluidic parameters or surface tension.However,singularities corresponding to enriched degrees of freedom(DOFs) embedded in XFEM arise in the discrete pressure Poisson equations.In this paper,constraints on these DOFs are derived from the interfacial equilibrium condition and introduced in terms of stabilized Lagrange multipliers designed for non-boundary-fitted meshes to address this issue.Numerical results show that the weak and strong discontinuities in pressure with straight and circular interfaces are accurately reproduced by the constraints.Comparisons with the SUPG/PSPG(streamline upwind/pressure stabilizing Petrov-Galerkin) method without Lagrange multipliers validate the applicability and flexibility of the proposed constrained algorithm to model problems with quasi-static interfaces.展开更多
基金National Nature Science Foundation of China(61872225)Natural Science Foundation of Shandong Province(ZR2020KF013,ZR2020ZD44,ZR2019ZD04,and ZR2020QF043)+1 种基金Introduction and Cultivation Program for Young Creative Talents in Colleges and Universities of Shandong Province(2019-173)Special Fund of Qilu Health and Health Leading Talents Training Project。
文摘Objective The resting-state functional magnetic resonance imaging(rs-f MRI)method was used to observe brain activity and its functional connection upon electroacupuncture stimulation at bilateral uterine acupoints(EX-CA1),as well as to investigate the mechanism of acupuncture in the treatment of gynecological diseases.Methods Twenty-two healthy female subjects were stimulated by electroacupuncture at bilateral uterine acupoints;rs-f MRI data of the brain were acquired and standardized.Degree centrality(DC),amplitude of low-frequency fluctuation(ALFF),and regional homogeneity(ReHo)were used to analyze local spontaneous brain activity via acupuncture.An independent component analysis was used to evaluate the functional connectivity of the resting brain networks after acupuncture.Results Analytical results showed that the neural activity intensity of the precuneus lobe,orbitofrontal cortex,lingual gyrus,amygdala,and posterior central gyrus decreased after acupuncture(voxel P<0.001,cluster P<0.05).Functional connectivity analysis revealed weakened auditory and right frontal-parietal networks(voxel P<0.001,cluster P<0.05),enhanced visual network(voxel P<0.001,cluster P<0.05),and synergistic auditory network and hypothalamic-pituitary system.Conclusion Significant differences in neural activity and functional connectivity in specific brain regions were observed after acupuncture intervention at uterine acupoints;the hypothalamic-pituitary system also showed various active states in different brain regions.It is speculated that the effective mechanism of acupuncture at uterine acupoints is related to the regulation of reproductive hormones,emotional changes,and somatic sensations.Therefore,the methods used in this study could clarify the neural mechanism of uterine-point acupuncture in the treatment of gynecological diseases and may serve as a reference for other studies pertaining to acupuncture.
文摘Y2001-62866-83 0118973电信管理网络中2维模拟:系统方法=Two-dimension-al modeling in TMN:a systems approach[会,英]/Liang,Y.& Lanman,M.//2000 International Confer-ence on Communication Technology Proceedings Vol.Ⅰof Ⅱ.—83～90(HC)基于分布目标技术的实现,本文提出 TMN 的2维模拟方法.此系统方法的关键理解就是依据 TMN中面向资源的信息(数据)目标分离计算接口的静态连接,并且能够强化计算目标中的计算接口,在运行时间内动态连接,这样用所提出模拟方法获得有效开放扩展的 TMN 结构,满足用户对快速服务产生和布置。
文摘The XFEM(extended finite element method) has a lot of advantages over other numerical methods to resolve discontinuities across quasi-static interfaces due to the jump in fluidic parameters or surface tension.However,singularities corresponding to enriched degrees of freedom(DOFs) embedded in XFEM arise in the discrete pressure Poisson equations.In this paper,constraints on these DOFs are derived from the interfacial equilibrium condition and introduced in terms of stabilized Lagrange multipliers designed for non-boundary-fitted meshes to address this issue.Numerical results show that the weak and strong discontinuities in pressure with straight and circular interfaces are accurately reproduced by the constraints.Comparisons with the SUPG/PSPG(streamline upwind/pressure stabilizing Petrov-Galerkin) method without Lagrange multipliers validate the applicability and flexibility of the proposed constrained algorithm to model problems with quasi-static interfaces.
