Objective: We assessed the safety and efficacy of two regimens for patients with gastrointestinal cancers: con-tinuous-infusion (CI) schedules of 5-Fluorouracil (5-Fu) plus a platinum (cisplatin or oxaliplatin) with/o...Objective: We assessed the safety and efficacy of two regimens for patients with gastrointestinal cancers: con-tinuous-infusion (CI) schedules of 5-Fluorouracil (5-Fu) plus a platinum (cisplatin or oxaliplatin) with/or without paclitaxel (regi-men A) versus Xeloda plus a platinum (cisplatin or oxaliplatin) with/or without paclitaxel for oral use (regimen B) in patients with gastrointestinal cancers. Methods: Between May 2003 and May 2005, 84 patients diagnosed in Jiangsu Cancer Hospital & Research Institute with locally advanced esophageal, gastric or colorectal cancer were registered. Regimen A and B con-sisted of either 5-Fu 0.375 CI days 1-14, every 28 days (n = 44), or Xeloda 1000 mg twice daily, days 1-14, every 28 days (n = 40). For both regimen A and B, IV cisplatin 25 mg/m2 was administered on day 1, 2 and 3 (or Oxaliplatin 75mg/m2 on day 1, 8 and 15) with or without paclitaxel 60-75 mg/m2 on day1, 8 and 15. Results: Patients receiving regimen B experienced significantly less stomatitis (P < 0.05) and diarrhea (P < 0.05), than those receiving regimen A. Prevalence of nausea/vomiting, alopecia, neutropenia, and hand-foot syndrome without significant difference between two regimens. No treatment related death occurred during study period. Regimen B demonstrates a similar, favorable safety profile in this study. Response rates and rates of clinical benefit for regimen A and B were 40.9%, 40.0% and 43.2%, 65.0% respectively. Conclusion: Based on its improved safety profile and improved rate of clinical benefit, Xeloda has the potential to replace CI 5-FU as an alternative treatment for patients with gastrointestinal cancers.展开更多
基金Supported by grants from the Jiangsu Provincial Personnel Department "the Great of Six Talented Man Peak" Project and the Jiangsu Cancer Hospital Emphasis Project (No. ZK200602).
文摘Objective: We assessed the safety and efficacy of two regimens for patients with gastrointestinal cancers: con-tinuous-infusion (CI) schedules of 5-Fluorouracil (5-Fu) plus a platinum (cisplatin or oxaliplatin) with/or without paclitaxel (regi-men A) versus Xeloda plus a platinum (cisplatin or oxaliplatin) with/or without paclitaxel for oral use (regimen B) in patients with gastrointestinal cancers. Methods: Between May 2003 and May 2005, 84 patients diagnosed in Jiangsu Cancer Hospital & Research Institute with locally advanced esophageal, gastric or colorectal cancer were registered. Regimen A and B con-sisted of either 5-Fu 0.375 CI days 1-14, every 28 days (n = 44), or Xeloda 1000 mg twice daily, days 1-14, every 28 days (n = 40). For both regimen A and B, IV cisplatin 25 mg/m2 was administered on day 1, 2 and 3 (or Oxaliplatin 75mg/m2 on day 1, 8 and 15) with or without paclitaxel 60-75 mg/m2 on day1, 8 and 15. Results: Patients receiving regimen B experienced significantly less stomatitis (P < 0.05) and diarrhea (P < 0.05), than those receiving regimen A. Prevalence of nausea/vomiting, alopecia, neutropenia, and hand-foot syndrome without significant difference between two regimens. No treatment related death occurred during study period. Regimen B demonstrates a similar, favorable safety profile in this study. Response rates and rates of clinical benefit for regimen A and B were 40.9%, 40.0% and 43.2%, 65.0% respectively. Conclusion: Based on its improved safety profile and improved rate of clinical benefit, Xeloda has the potential to replace CI 5-FU as an alternative treatment for patients with gastrointestinal cancers.
