Based on the difference in tendency to polymerize between tungsten and molybdenum, a new method using D309 resin was propounded. The batch tests indicate that the optimum pH value and contact time for the separation a...Based on the difference in tendency to polymerize between tungsten and molybdenum, a new method using D309 resin was propounded. The batch tests indicate that the optimum pH value and contact time for the separation are 7.0 and 4 h respectively, the maxium separation factor of W and Mo is 9.29. And the experimental resules show that isothermal absorbing tungsten and molybdenum belongs to Langmuir model and Freundlich model respectively, and the absorbing kinetics for tungsten is controlled by intra-particle diffusion. With a solution containing 70 g/L WO3 and 28.97 g/L Mo, the effluent with a mass ratio of Mo to WO3 of 76 and the eluate with a mass ratio of WO3 to Mo of 53.33 are obtained after column test.展开更多
The dynamic and static modulus of elasticity (MOE) between bluestained and non-bluestained lumber of Lodgepole pine were tested and analyzed by using three methods of Non-destructive testing (NDT), Portable Ultras...The dynamic and static modulus of elasticity (MOE) between bluestained and non-bluestained lumber of Lodgepole pine were tested and analyzed by using three methods of Non-destructive testing (NDT), Portable Ultrasonic Non-destructive Digital Indicating Testing (Pundit), Metriguard and Fast Fourier Transform (FFT) and the normal bending method. Results showed that the dynamic and static MOE of bluestained wood were higher than those of non-bluestained wood. The significant differences in dynamic MOE and static MOE were found between bulestained and non-bluestained wood, of which, the difference in each of three dynamic MOE (Ep. the ultrasonic wave modulus of elasticity, Ems, the stress wave modulus of elasticity and El, the longitudinal wave modulus of elasticity) between bulestained and non-bluestained wood arrived at the 0.01 significance level, whereas that in the static MOE at the 0.05 significance level. The differences in MOE between bulestained and non-bluestained wood were induced by the variation between sapwood and heartwood and the different densities of bulestained and non-bluestained wood. The correlation between dynamic MOE and static MOE was statistically significant at the 0.01 significance level. Although the dynamic MOE values of Ep, Em, Er were significantly different, there exists a close relationship between them (arriving at the 0.01 correlation level). Comparative analysis among the three techniques indicated that the accurateness of FFT was higher than that of Pundit and Metriguard. Effect of tree knots on MOE was also investigated. Result showed that the dynamic and static MOE gradually decreased with the increase of knot number, indicating that knot number had significant effect on MOE value.展开更多
To study the seismic performance of double-skin steelconcrete composite box( DSCB) piers, a total of 11 DSCB pier specimens were tested under bidirectional cyclic loading. The effects of the loading pattern, the ste...To study the seismic performance of double-skin steelconcrete composite box( DSCB) piers, a total of 11 DSCB pier specimens were tested under bidirectional cyclic loading. The effects of the loading pattern, the steel plate thickness, the axial load ratio, the slenderness ratio and the aspect ratio were taken into consideration. The damage evolution process and failure modes of the tested specimens are presented in detail. Test results are also discussed in terms of the hysteretic curve, skeleton curve, ductility and energy dissipation capacity of DSCB pier specimens. It can be concluded that the hysteretic performance of DSCB piers in one direction is affected and weakened by the cyclic loading in the other direction. DSCB piers under bidirectional cyclic loading exhibit good performance in terms of load carrying capacity, ductility, and energy dissipation capacity. Overall, DSCB piers can meet the basic aseismic requirements. The research results can be taken as a reference for using DSCB piers as high piers in bridges in strong earthquakeprone areas.展开更多
Eight new cyclopyrrolone compounds were synthesized according to the structure activity relationship and action mechanism of Zopiclone, a cyclopyrrolone hypnotic. Their preliminary pharmacodynamics are under investig...Eight new cyclopyrrolone compounds were synthesized according to the structure activity relationship and action mechanism of Zopiclone, a cyclopyrrolone hypnotic. Their preliminary pharmacodynamics are under investigation.展开更多
This paper proposes a novel collision post structure designed to improve the crashworthiness of subway cab cars.The structure provides two innovative features:1)a simpler connection between the post and the car roof,w...This paper proposes a novel collision post structure designed to improve the crashworthiness of subway cab cars.The structure provides two innovative features:1)a simpler connection between the post and the car roof,which gives a more reasonable load transfer path to reduce the stress concentration at the joint;and 2)a stiffness induction design that provides an ideal deformation model to protect the safe space of the cab cars.The novel collision post structure was evaluated with finite element analysis,and a prototype cab car was mechanically tested.The results demonstrate that the deformation response was stable and agreed well with the expected ideal mode.The maximum load was 874.17 kN and the responses remained well above the elastic design load of 334 kN as required by the design specification.In addition,there was no significant tearing failure during the whole test process.Therefore,the novel collision post structure proposed has met the requirements specified in new standard to improve the crashworthiness of subway cab cars.Finally,the energy absorption efficiency and light weight design highlights were also summarized and discussed.展开更多
According to the catastrophe model for impact buckling of static loading structures, a new catastrophe model for impact loading failure of a static loading rock system was established, and one dimension (1D) catastrop...According to the catastrophe model for impact buckling of static loading structures, a new catastrophe model for impact loading failure of a static loading rock system was established, and one dimension (1D) catastrophe model was analyzed. The analysis results indicate that the furcation collection where catastrophe may take place is not only decided by mechanical system itself but also relates to exterior loading, which is different from the results obtained under mono-static loading where the bifurcation collection is only determined by mechanics of the system itself and has nothing to do with exterior loading. In addition, the corresponding 1D coupled static-dynamic loading experiment is designed to verify the analysis results of catastrophe model. The test is done with Instron 1342 electro-servo controlled testing system, in which medium strain rate is caused by monotony rising dynamic load. The parameters are obtained combining theoretical model with experiment. The experimental and theoretical curves of critical dynamic load vs static load are rather coincided, thus the new model is proved to be correct.展开更多
AIM: To establish the pig model of pancreatoduodena transplantation with enteric drainage (ED) and porta venous drainage (PVD). METHODS: Forty-six hybrid Landrace pigs were divided into two groups (donors and r...AIM: To establish the pig model of pancreatoduodena transplantation with enteric drainage (ED) and porta venous drainage (PVD). METHODS: Forty-six hybrid Landrace pigs were divided into two groups (donors and recipients) randomly, and pancreatoduodenal allotransplantation was performed. Donors were perfused via abdominal aorta without clamping the portal venous outflow with UW solution at 80-100 cm H2O after heparinization. Whole pancreatoduodenal grafts were harvested with segments of abdominal aorta and portal vein, and shaped under 4℃ UW solution. Then, end-to-end anastomosis was performed with the donor iliac artery bifurcation Y graft to the recipient superior mesenteric artery and celiac artery. Furthermore, type I diabetes model was made by removal of the recipient pancreas. The venous anastomosis was reconstructed between the donor portal vein and the recipient superior mesentery vein. Meanwhile, end-toside anastomosis was performed with the donor common iliac artery bifurcation Y graft to the recipient abdominal aorta, and side-to-side intestinal anastomosis was performed between the donor duodenum and the recipient jejunum. External jugular vein was intubated for transfusion. Levels of plasma glucose, insulin and glucagon were measured during the operation and on the 1^st 3^rd 5^th and 7^th d after operation. RESULTS: Pancreatoduodenal allotransplantation was performed on 23 pigs of which 1 died of complication of anesthesia. The success rate of operation was 95.6%. Complications of operation occurred in two cases in which one was phlebothrombosis with an incidence of 4.6%, and the other was duodenojejunal anastomotic leak with an incidence of 4.6%. The level of plasma glucose decreased within 30 min, after removal of pancreas and recovered on the 2^nd after operation. The level of plasmainsulin and glucagon increased within 30 min after removal of pancreas and recovered on the 2^nd d after operation. Rejection occurred on the 1^st and reached the worst level on the 7^th d after transplantation, without change of plasma insulin and glucagon or clinical symptoms of rejection. CONCLUSION: Pancreatoduodenal transplantation in pigs can treat type I diabetes. ED and PVD can keep the function of endocrine in normal. The technique of pancreatoduodenal transplantation with ED and PVD may pave the way for the further application of pancreas transplantation in clinic.展开更多
The uniaxial compression tests for mudstone specimens are carried out with four different loading rates from room temperature to 400℃ by using the Rock Mechanics Servo-controlled Testing System MTS810 and high temper...The uniaxial compression tests for mudstone specimens are carried out with four different loading rates from room temperature to 400℃ by using the Rock Mechanics Servo-controlled Testing System MTS810 and high temperature furnace MTS652.02.The mechanical properties of mudstone with various loading rates are studied under different temperature conditions.The results show that when temperature increases from room temperature to 400℃ and loading rate is less than 0.03 mm/s,the peak strength of mudstone specimen decreases as loading rate increases,while the various peak strengths show significant differences when loading rate exceeds 0.03 mm/s.At room temperature,the elastic modulus decreases at the first time and then increases with loading rate rising.When the temperature is between200 and 400℃,the elastic modulus presents a decreasing trend with increasing loading rate.With increasing the loading rate,the number of fragments in mudstone becomes larger and even the powder is observed in mudstone with higher loading rate.Under high loading rate,the failure mode of mudstone specimens under different temperatures is mainly conical damage.展开更多
Effect of soil displacement on friction single pile in the cases of tunneling,surcharge load and uniform soil movement was discussed in details with finite element method.Lateral displacement of the pile caused by soi...Effect of soil displacement on friction single pile in the cases of tunneling,surcharge load and uniform soil movement was discussed in details with finite element method.Lateral displacement of the pile caused by soil displacement reached about 90% of the total displacement,which means that P-Δ effect of axial load can be neglected.The maximum moment of pile decreased from 159 kN·m to 133 kN·m in the case of surcharge load when the axial load increased from 0 to the ultimate load.When deformation of pile caused by soil displacement is large,axial load applied on pile-head plays the role of reducing the maximum bending moment in concrete pile to some extent.When pile is on one side of the tunnel,soil displacements around the pile are all alike,which means that the soil pressures around the pile do not decrease during tunneling.Therefore,Q-s curve of the pile affected by tunneling is very close to that of pile in static loading test.Bearing capacities of piles influenced by surcharge load and uniform soil movement are 2480 kN and 2630 kN,respectively,which are a little greater than that of the pile in static loading test(2400 kN).Soil pressures along pile increase due to surcharge load and uniform soil movement,and so do the shaft resistances along pile,as a result,when rebars in concrete piles are enough,bearing capacity of pile affected by soil displacement increases compared with that of pile in static loading test.展开更多
AIM: To investigate the potential role of continuous venovenous hemofiltration (CVVH) in hemodynamics and oxygen metabolism in pigs with severe acute pancreatitis (SAP). METHODS: SAP model was produced by intraductal ...AIM: To investigate the potential role of continuous venovenous hemofiltration (CVVH) in hemodynamics and oxygen metabolism in pigs with severe acute pancreatitis (SAP). METHODS: SAP model was produced by intraductal injection of sodium taurocholate [4%, 1 mL/kg body weight (BW)] and trypsin (2 U/kg BW). Animals were allocated either to untreated controls as group 1 or to one of two treatment groups as group 2 receiving a low-volume CVVH [20 mL/(kg·h)], and group 3 receiving a high-volume CVVH [100 (mL/kg·h)]. Swan-Ganz catheter was inserted during the operation. Heart rate, arterial blood pressure, cardiac output, mean pulmonary arterial pressure, pulmonary arterial wedge pressure, central venous pressure, systemic vascular resistance, oxygen delivery, oxygen consumption, oxygen extraction ratio, as well as survival of pigs were evaluated in the study. RESULTS: Survival time was significantly prolonged by low-volume and high-volume CVVHs, which was more pronounced in the latter. High-volume CVVH was significantly superior compared with less intensive treatment modalities (low-volume CVVH) in systemic inflammatory reaction protection. The major hemodynamic finding was that pancreatitis-induced hypotension was significantly attenuated by intensive CVVH (87.4±12.5 kPa vs116.3±7.8 kPa,P<0.01). The development of hyperdynamic circulatory failure was simultaneously attenuated, as reflected by a limited increase in cardiac output, an attenuated decrease in systemic vascular resistance and an elevation in oxygen extraction ratio. CONCLUSION: CVVH blunts the pancreatitis-induced cardiovascular response and increases tissue oxygen extraction. The high-volume CVVH is distinctly superior in preventing sepsis-related hemodynamic impairment.展开更多
Cone penetration test(CPT)is an appropriate technique for quickly determining the geotechnical properties of lunar soil,which is valuable for in situ lunar exploration.Utilizing a typical coupling method recently deve...Cone penetration test(CPT)is an appropriate technique for quickly determining the geotechnical properties of lunar soil,which is valuable for in situ lunar exploration.Utilizing a typical coupling method recently developed by the authors,a finite element method(FEM)-discrete element method(DEM)coupled model of CPTs is obtained.A series of CPTs in lunar soil are simulated to qualitatively reveal the flow of particles and the development of resistance throughout the penetration process.In addition,the effects of major factors,such as penetration velocity,penetration depth,cone tip angle,and the low gravity on the Moon surface are investigated.展开更多
We present a series of experimental tests on chemical grouting into a fracture with flowing and static water,using a transparent fracture grouting experimental device.Variations of seepage pressure and grout propagati...We present a series of experimental tests on chemical grouting into a fracture with flowing and static water,using a transparent fracture grouting experimental device.Variations of seepage pressure and grout propagation were compared in our investigation.The results show that flowing water results in drops of seepage pressure,development of penetration radii in the upstream side and drops of propagation area during the same period,compared with grouting in static water.The propagation area in static water is always round before grouts reach the joint boundaries.However,the propagation shape changes from round to an elliptic shape for grouting into a fracture with flowing water.A theoretical model for the grout penetration radius in a fracture considering flowing velocity was developed and validated by our experimental results.These results are helpful in improving understanding of fracture grouting mechanism and in guiding engineering practices.展开更多
This paper puts forward a new rock fragmentation loading method of dual-cutter head combined dynamic and static loads. By applying the numerical simulation software - RFPA2D, we have done numerical experiment about th...This paper puts forward a new rock fragmentation loading method of dual-cutter head combined dynamic and static loads. By applying the numerical simulation software - RFPA2D, we have done numerical experiment about the sihstone' s crushing effect by dynamic load on single cutter head without confining pressure, dynamic load on single cut- ter head with confining pressure 10 MPa and different dual-cutter heads spacing by combined dynamic and static loads with confining pressure 10 MPa. Experimental results show that the confining pressure can obviously affect the rock frag- mentation effect. Combined dynamic and static loads can greatly improve the rock fragmentation effect. There exists an optimal spacing of dual-cutter head that can make the rock fragmentation achieve the desired effect. Through analyzing the acoustic emission accumulative energy and quantity, the authors make a conclusion that the optimum spacing is 30 mm.展开更多
The paper is devoted to the elastostatic calibration of industrial robots, which is used for precise machining of large-dimensional parts made of composite materials. In this technological process, the interaction bet...The paper is devoted to the elastostatic calibration of industrial robots, which is used for precise machining of large-dimensional parts made of composite materials. In this technological process, the interaction between the robot and the workpiece causes essential elastic deflections of the manipulator components that should be compensated by the robot controller using relevant elastostatic model of this mechanism. To estimate parameters of this model, an advanced calibration technique is applied that is based on the non-linear experiment design theory, which is adopted for this particular application. In contrast to previous works, it is proposed a concept of the user-defined test-pose, which is used to evaluate the calibration experiments quality. In the frame of this concept, the related optimization problem is defined and numerical routines are developed, which allow generating optimal set of manipulator configurations and corresponding forces/torques for a given number of the calibration experiments. Some specific kinematic constraints are also taken into account, which insure feasibility of calibration experiments for the obtained configurations and allow avoiding collision between the robotic manipulator and the measurement equipment. The efficiency of the developed technique is illustrated by an application example that deals with elastostatic calibration of the serial manipulator used for robot-based machining.展开更多
Objective To investigate the short- and long-term therapeutic efficacies of intravenous transplantation of bone marrow stem cells(MSCs) in rats with experimental myocardial infarction by metaanalysis.Methods Randomize...Objective To investigate the short- and long-term therapeutic efficacies of intravenous transplantation of bone marrow stem cells(MSCs) in rats with experimental myocardial infarction by metaanalysis.Methods Randomized controlled trials were systematically searched from Pub Med,Science Citation Index(SCI),Chinese journal full-text database(CJFD) up to December 2014.While the experimental groups(MSCs groups) were injected MSCs intravenously,the control groups were injected Delubecco's minimum essential medium(DMEM) or phosphate buffered saline(PBS).Subgroup analysis for each outcome measure was performed for the observing time point after the transplantation of MSCs.Weighted mean differences(WMD) and 95% confidence intervals(CI) were calculated for outcome parameters including ejection fraction(EF) and fractional shortening(FS),which were measured by echocardiogram after intravenous injection and analyzed by Rev Man 5.2 and STATA 12.0.Results Data from 9 studies(190 rats) were included in the meta-analysis.As compared to the control groups,the cardiac function of the experimental groups were not improved at day 7(EF:WMD=0.08,95%CI-1.32 to 1.16,P>0.01; FS:WMD=-0.12,95%CI-0.90 to 0.65,P>0.01) until at day 14 after MSCs' transplantation(EF:WMD=10.79,95%CI 9.16 to 12.42,P<0.01; FS:WMD=11.34,95%CI 10.44 to 12.23,P<0.01),and it lasted 4 weeks or more after transplantation of MSCs(EF:WMD=13.94,95%CI 12.24 to 15.64,P<0.01; FS:WMD=9.64,95%CI 7.98 to 11.31,P<0.01).Conclusion The therapeutic efficacies of MSCs in rats with myocardid infarction become increasing apparent as time advances since 2 weeks after injection.展开更多
The comparative research on the seismic performance of grouted sleeve connected pier(GS)and prestressed precast segmental concrete pier(PC)is mostly carried out by numerical simulation.In this study,the GS pier and th...The comparative research on the seismic performance of grouted sleeve connected pier(GS)and prestressed precast segmental concrete pier(PC)is mostly carried out by numerical simulation.In this study,the GS pier and the PC pier of the new railway project from Hetian to Ruoqiang are taken into consideration.Two kinds of 1/5-scale assembled double-column specimens are made,and the quasi-static tests are carried out.The overall seismic performance of the two spliced piers is studied,and compared in terms of failure mechanism,bearing capacity,ductility,stiffness and energy dissipation capacity.The results show that the failure modes of both GS pier and PC pier are characterized by bending.However,the specific failure location and form are different.The GS pier presents a complete hysteretic curve,large equivalent stiffness and strong energy dissipation capacity.The hysteretic area of the PC pier is small.However,it has good self-reset ability and quasi-static residual displacement.Finite element models are set up using DispBeamColumn fiber elements and ZeroLength elements.The models that are calibrated with the test data can effectively simulate the damage development under monotonic loading.The load−displacement curves are in good agreement with the backbone curves of the test results.展开更多
The deformation behavior of hot isostatic pressing (HIP) FGH96 superalloy was characterized in the temperature range of 1000-1100 ℃ and strain rate range of 0. 001-0. 1 s^-1 using hot compression testing. The flow ...The deformation behavior of hot isostatic pressing (HIP) FGH96 superalloy was characterized in the temperature range of 1000-1100 ℃ and strain rate range of 0. 001-0. 1 s^-1 using hot compression testing. The flow curves of HIP FGH96, superalloy during hot deformation was analyzed systematically. The results show that deformation temperature, strain rate and strain are the main influence factors on flow stress of HIP FGH96 superalloy during hot deformation. The flow stress displays a peak at a critical strain and then decreases with further increase in strain. For a given strain, the flow stress decreases with the increase of deformation temperature, and increases with the increase of strain rate. A mathematical model of these flow curves was established through regression analysis and taking the strain as a modification factor. The calculated stress values agree well with the experimental values.展开更多
Portal hypertension can be caused by a wide variety of conditions.It frequently presents with bleeding from esophageal varices.The approach to acute variceal hemorrhage in children is a stepwise progression from least...Portal hypertension can be caused by a wide variety of conditions.It frequently presents with bleeding from esophageal varices.The approach to acute variceal hemorrhage in children is a stepwise progression from least invasive to most invasive.Management of acute variceal bleeding is straightforward.But data on primary prophylaxis and long term management prevention of recurrent variceal bleeding in children is scarce,therefore prospective multicenter trials are needed to establish best practices.展开更多
基金Project(51174232)supported by the National Natural Science Foundation of China
文摘Based on the difference in tendency to polymerize between tungsten and molybdenum, a new method using D309 resin was propounded. The batch tests indicate that the optimum pH value and contact time for the separation are 7.0 and 4 h respectively, the maxium separation factor of W and Mo is 9.29. And the experimental resules show that isothermal absorbing tungsten and molybdenum belongs to Langmuir model and Freundlich model respectively, and the absorbing kinetics for tungsten is controlled by intra-particle diffusion. With a solution containing 70 g/L WO3 and 28.97 g/L Mo, the effluent with a mass ratio of Mo to WO3 of 76 and the eluate with a mass ratio of WO3 to Mo of 53.33 are obtained after column test.
基金This paper was supported by "Wood-inorganic Res-toration Material" in "Technique Introduction and Innovation of Bio-macromolecule New Material" of Introducing Overseas Advanced Forest Technology Innovation Program of China ("948" Innovation Pro-ject, Number: 2006-4-C03)
文摘The dynamic and static modulus of elasticity (MOE) between bluestained and non-bluestained lumber of Lodgepole pine were tested and analyzed by using three methods of Non-destructive testing (NDT), Portable Ultrasonic Non-destructive Digital Indicating Testing (Pundit), Metriguard and Fast Fourier Transform (FFT) and the normal bending method. Results showed that the dynamic and static MOE of bluestained wood were higher than those of non-bluestained wood. The significant differences in dynamic MOE and static MOE were found between bulestained and non-bluestained wood, of which, the difference in each of three dynamic MOE (Ep. the ultrasonic wave modulus of elasticity, Ems, the stress wave modulus of elasticity and El, the longitudinal wave modulus of elasticity) between bulestained and non-bluestained wood arrived at the 0.01 significance level, whereas that in the static MOE at the 0.05 significance level. The differences in MOE between bulestained and non-bluestained wood were induced by the variation between sapwood and heartwood and the different densities of bulestained and non-bluestained wood. The correlation between dynamic MOE and static MOE was statistically significant at the 0.01 significance level. Although the dynamic MOE values of Ep, Em, Er were significantly different, there exists a close relationship between them (arriving at the 0.01 correlation level). Comparative analysis among the three techniques indicated that the accurateness of FFT was higher than that of Pundit and Metriguard. Effect of tree knots on MOE was also investigated. Result showed that the dynamic and static MOE gradually decreased with the increase of knot number, indicating that knot number had significant effect on MOE value.
基金The National Natural Science Foundation of China(No.5117810151378112)the Doctoral Fund of Ministry of Education(No.20110092110011)
文摘To study the seismic performance of double-skin steelconcrete composite box( DSCB) piers, a total of 11 DSCB pier specimens were tested under bidirectional cyclic loading. The effects of the loading pattern, the steel plate thickness, the axial load ratio, the slenderness ratio and the aspect ratio were taken into consideration. The damage evolution process and failure modes of the tested specimens are presented in detail. Test results are also discussed in terms of the hysteretic curve, skeleton curve, ductility and energy dissipation capacity of DSCB pier specimens. It can be concluded that the hysteretic performance of DSCB piers in one direction is affected and weakened by the cyclic loading in the other direction. DSCB piers under bidirectional cyclic loading exhibit good performance in terms of load carrying capacity, ductility, and energy dissipation capacity. Overall, DSCB piers can meet the basic aseismic requirements. The research results can be taken as a reference for using DSCB piers as high piers in bridges in strong earthquakeprone areas.
文摘Eight new cyclopyrrolone compounds were synthesized according to the structure activity relationship and action mechanism of Zopiclone, a cyclopyrrolone hypnotic. Their preliminary pharmacodynamics are under investigation.
基金Project(2016YFB1200505-016)supported by the National Key Research and Development Program of ChinaProject(51675537)supported by the National Natural Science Foundation of ChinaProject(2018zzts161)supported by the Independent Exploration and Innovation Project of Central South University,China。
文摘This paper proposes a novel collision post structure designed to improve the crashworthiness of subway cab cars.The structure provides two innovative features:1)a simpler connection between the post and the car roof,which gives a more reasonable load transfer path to reduce the stress concentration at the joint;and 2)a stiffness induction design that provides an ideal deformation model to protect the safe space of the cab cars.The novel collision post structure was evaluated with finite element analysis,and a prototype cab car was mechanically tested.The results demonstrate that the deformation response was stable and agreed well with the expected ideal mode.The maximum load was 874.17 kN and the responses remained well above the elastic design load of 334 kN as required by the design specification.In addition,there was no significant tearing failure during the whole test process.Therefore,the novel collision post structure proposed has met the requirements specified in new standard to improve the crashworthiness of subway cab cars.Finally,the energy absorption efficiency and light weight design highlights were also summarized and discussed.
基金Project(50490272 ,50490274 ,10472134) supported by the Natural Science Foundation of China project(2005038250)supported by the China Postdoctoral Foundation
文摘According to the catastrophe model for impact buckling of static loading structures, a new catastrophe model for impact loading failure of a static loading rock system was established, and one dimension (1D) catastrophe model was analyzed. The analysis results indicate that the furcation collection where catastrophe may take place is not only decided by mechanical system itself but also relates to exterior loading, which is different from the results obtained under mono-static loading where the bifurcation collection is only determined by mechanics of the system itself and has nothing to do with exterior loading. In addition, the corresponding 1D coupled static-dynamic loading experiment is designed to verify the analysis results of catastrophe model. The test is done with Instron 1342 electro-servo controlled testing system, in which medium strain rate is caused by monotony rising dynamic load. The parameters are obtained combining theoretical model with experiment. The experimental and theoretical curves of critical dynamic load vs static load are rather coincided, thus the new model is proved to be correct.
基金Supported by the Doctorate Foundation of Ministry of Education of China, No. 20030610071 Foundation of China Medical Board of New York, No. 82412
文摘AIM: To establish the pig model of pancreatoduodena transplantation with enteric drainage (ED) and porta venous drainage (PVD). METHODS: Forty-six hybrid Landrace pigs were divided into two groups (donors and recipients) randomly, and pancreatoduodenal allotransplantation was performed. Donors were perfused via abdominal aorta without clamping the portal venous outflow with UW solution at 80-100 cm H2O after heparinization. Whole pancreatoduodenal grafts were harvested with segments of abdominal aorta and portal vein, and shaped under 4℃ UW solution. Then, end-to-end anastomosis was performed with the donor iliac artery bifurcation Y graft to the recipient superior mesenteric artery and celiac artery. Furthermore, type I diabetes model was made by removal of the recipient pancreas. The venous anastomosis was reconstructed between the donor portal vein and the recipient superior mesentery vein. Meanwhile, end-toside anastomosis was performed with the donor common iliac artery bifurcation Y graft to the recipient abdominal aorta, and side-to-side intestinal anastomosis was performed between the donor duodenum and the recipient jejunum. External jugular vein was intubated for transfusion. Levels of plasma glucose, insulin and glucagon were measured during the operation and on the 1^st 3^rd 5^th and 7^th d after operation. RESULTS: Pancreatoduodenal allotransplantation was performed on 23 pigs of which 1 died of complication of anesthesia. The success rate of operation was 95.6%. Complications of operation occurred in two cases in which one was phlebothrombosis with an incidence of 4.6%, and the other was duodenojejunal anastomotic leak with an incidence of 4.6%. The level of plasma glucose decreased within 30 min, after removal of pancreas and recovered on the 2^nd after operation. The level of plasmainsulin and glucagon increased within 30 min after removal of pancreas and recovered on the 2^nd d after operation. Rejection occurred on the 1^st and reached the worst level on the 7^th d after transplantation, without change of plasma insulin and glucagon or clinical symptoms of rejection. CONCLUSION: Pancreatoduodenal transplantation in pigs can treat type I diabetes. ED and PVD can keep the function of endocrine in normal. The technique of pancreatoduodenal transplantation with ED and PVD may pave the way for the further application of pancreas transplantation in clinic.
基金supported by the National Natural Science Foundation of China(Nos.51104128,51322401,51304201 and 51204159)Jiangsu Province Prospective industry-UniversityResearch Cooperation Research Program of China(No.BY2012085)+2 种基金Doctor Station Fund of China(No.20120095110013)333 Project Program of Jiangsu Province of China"Blue Project" Program of Jiangsu Province of China
文摘The uniaxial compression tests for mudstone specimens are carried out with four different loading rates from room temperature to 400℃ by using the Rock Mechanics Servo-controlled Testing System MTS810 and high temperature furnace MTS652.02.The mechanical properties of mudstone with various loading rates are studied under different temperature conditions.The results show that when temperature increases from room temperature to 400℃ and loading rate is less than 0.03 mm/s,the peak strength of mudstone specimen decreases as loading rate increases,while the various peak strengths show significant differences when loading rate exceeds 0.03 mm/s.At room temperature,the elastic modulus decreases at the first time and then increases with loading rate rising.When the temperature is between200 and 400℃,the elastic modulus presents a decreasing trend with increasing loading rate.With increasing the loading rate,the number of fragments in mudstone becomes larger and even the powder is observed in mudstone with higher loading rate.Under high loading rate,the failure mode of mudstone specimens under different temperatures is mainly conical damage.
基金Project(51208071)supported by the National Natural Science Foundation of ChinaProject(2010CB732106)supported by the National Basic Research Program of China
文摘Effect of soil displacement on friction single pile in the cases of tunneling,surcharge load and uniform soil movement was discussed in details with finite element method.Lateral displacement of the pile caused by soil displacement reached about 90% of the total displacement,which means that P-Δ effect of axial load can be neglected.The maximum moment of pile decreased from 159 kN·m to 133 kN·m in the case of surcharge load when the axial load increased from 0 to the ultimate load.When deformation of pile caused by soil displacement is large,axial load applied on pile-head plays the role of reducing the maximum bending moment in concrete pile to some extent.When pile is on one side of the tunnel,soil displacements around the pile are all alike,which means that the soil pressures around the pile do not decrease during tunneling.Therefore,Q-s curve of the pile affected by tunneling is very close to that of pile in static loading test.Bearing capacities of piles influenced by surcharge load and uniform soil movement are 2480 kN and 2630 kN,respectively,which are a little greater than that of the pile in static loading test(2400 kN).Soil pressures along pile increase due to surcharge load and uniform soil movement,and so do the shaft resistances along pile,as a result,when rebars in concrete piles are enough,bearing capacity of pile affected by soil displacement increases compared with that of pile in static loading test.
基金Supported by the Social Development Foundation of Jiangsu Province, No.BS2000051
文摘AIM: To investigate the potential role of continuous venovenous hemofiltration (CVVH) in hemodynamics and oxygen metabolism in pigs with severe acute pancreatitis (SAP). METHODS: SAP model was produced by intraductal injection of sodium taurocholate [4%, 1 mL/kg body weight (BW)] and trypsin (2 U/kg BW). Animals were allocated either to untreated controls as group 1 or to one of two treatment groups as group 2 receiving a low-volume CVVH [20 mL/(kg·h)], and group 3 receiving a high-volume CVVH [100 (mL/kg·h)]. Swan-Ganz catheter was inserted during the operation. Heart rate, arterial blood pressure, cardiac output, mean pulmonary arterial pressure, pulmonary arterial wedge pressure, central venous pressure, systemic vascular resistance, oxygen delivery, oxygen consumption, oxygen extraction ratio, as well as survival of pigs were evaluated in the study. RESULTS: Survival time was significantly prolonged by low-volume and high-volume CVVHs, which was more pronounced in the latter. High-volume CVVH was significantly superior compared with less intensive treatment modalities (low-volume CVVH) in systemic inflammatory reaction protection. The major hemodynamic finding was that pancreatitis-induced hypotension was significantly attenuated by intensive CVVH (87.4±12.5 kPa vs116.3±7.8 kPa,P<0.01). The development of hyperdynamic circulatory failure was simultaneously attenuated, as reflected by a limited increase in cardiac output, an attenuated decrease in systemic vascular resistance and an elevation in oxygen extraction ratio. CONCLUSION: CVVH blunts the pancreatitis-induced cardiovascular response and increases tissue oxygen extraction. The high-volume CVVH is distinctly superior in preventing sepsis-related hemodynamic impairment.
基金Project(51278451) supported by the National Natural Science Foundation of ChinaProject(LZ12E09001) supported by the Zhejiang Natural Science Foundation,China
文摘Cone penetration test(CPT)is an appropriate technique for quickly determining the geotechnical properties of lunar soil,which is valuable for in situ lunar exploration.Utilizing a typical coupling method recently developed by the authors,a finite element method(FEM)-discrete element method(DEM)coupled model of CPTs is obtained.A series of CPTs in lunar soil are simulated to qualitatively reveal the flow of particles and the development of resistance throughout the penetration process.In addition,the effects of major factors,such as penetration velocity,penetration depth,cone tip angle,and the low gravity on the Moon surface are investigated.
基金Financial support for this work,provided by the National Natural Science Foundation of China(Nos.40772192 and 41072237)the State Key Laboratort of Geomechanics and Deep Underground Engineering(No.SKLGDUEK0903)the Specialized Research Fund for the Doctoral Program of Higher Education of China(No.20100095110015)
文摘We present a series of experimental tests on chemical grouting into a fracture with flowing and static water,using a transparent fracture grouting experimental device.Variations of seepage pressure and grout propagation were compared in our investigation.The results show that flowing water results in drops of seepage pressure,development of penetration radii in the upstream side and drops of propagation area during the same period,compared with grouting in static water.The propagation area in static water is always round before grouts reach the joint boundaries.However,the propagation shape changes from round to an elliptic shape for grouting into a fracture with flowing water.A theoretical model for the grout penetration radius in a fracture considering flowing velocity was developed and validated by our experimental results.These results are helpful in improving understanding of fracture grouting mechanism and in guiding engineering practices.
基金National Science Foundation of China (No.50974059No.50934006)
文摘This paper puts forward a new rock fragmentation loading method of dual-cutter head combined dynamic and static loads. By applying the numerical simulation software - RFPA2D, we have done numerical experiment about the sihstone' s crushing effect by dynamic load on single cutter head without confining pressure, dynamic load on single cut- ter head with confining pressure 10 MPa and different dual-cutter heads spacing by combined dynamic and static loads with confining pressure 10 MPa. Experimental results show that the confining pressure can obviously affect the rock frag- mentation effect. Combined dynamic and static loads can greatly improve the rock fragmentation effect. There exists an optimal spacing of dual-cutter head that can make the rock fragmentation achieve the desired effect. Through analyzing the acoustic emission accumulative energy and quantity, the authors make a conclusion that the optimum spacing is 30 mm.
文摘The paper is devoted to the elastostatic calibration of industrial robots, which is used for precise machining of large-dimensional parts made of composite materials. In this technological process, the interaction between the robot and the workpiece causes essential elastic deflections of the manipulator components that should be compensated by the robot controller using relevant elastostatic model of this mechanism. To estimate parameters of this model, an advanced calibration technique is applied that is based on the non-linear experiment design theory, which is adopted for this particular application. In contrast to previous works, it is proposed a concept of the user-defined test-pose, which is used to evaluate the calibration experiments quality. In the frame of this concept, the related optimization problem is defined and numerical routines are developed, which allow generating optimal set of manipulator configurations and corresponding forces/torques for a given number of the calibration experiments. Some specific kinematic constraints are also taken into account, which insure feasibility of calibration experiments for the obtained configurations and allow avoiding collision between the robotic manipulator and the measurement equipment. The efficiency of the developed technique is illustrated by an application example that deals with elastostatic calibration of the serial manipulator used for robot-based machining.
基金Supported by the Youth Project of National Natural Science Foundation(81100078)the Key Project of Chinese Ministry of Education(211207)+1 种基金Guangzhou Pearl River science and technology new star project plan(2012J2200063)Project of Guangdong Science and Technology Department(S2011040001392)
文摘Objective To investigate the short- and long-term therapeutic efficacies of intravenous transplantation of bone marrow stem cells(MSCs) in rats with experimental myocardial infarction by metaanalysis.Methods Randomized controlled trials were systematically searched from Pub Med,Science Citation Index(SCI),Chinese journal full-text database(CJFD) up to December 2014.While the experimental groups(MSCs groups) were injected MSCs intravenously,the control groups were injected Delubecco's minimum essential medium(DMEM) or phosphate buffered saline(PBS).Subgroup analysis for each outcome measure was performed for the observing time point after the transplantation of MSCs.Weighted mean differences(WMD) and 95% confidence intervals(CI) were calculated for outcome parameters including ejection fraction(EF) and fractional shortening(FS),which were measured by echocardiogram after intravenous injection and analyzed by Rev Man 5.2 and STATA 12.0.Results Data from 9 studies(190 rats) were included in the meta-analysis.As compared to the control groups,the cardiac function of the experimental groups were not improved at day 7(EF:WMD=0.08,95%CI-1.32 to 1.16,P>0.01; FS:WMD=-0.12,95%CI-0.90 to 0.65,P>0.01) until at day 14 after MSCs' transplantation(EF:WMD=10.79,95%CI 9.16 to 12.42,P<0.01; FS:WMD=11.34,95%CI 10.44 to 12.23,P<0.01),and it lasted 4 weeks or more after transplantation of MSCs(EF:WMD=13.94,95%CI 12.24 to 15.64,P<0.01; FS:WMD=9.64,95%CI 7.98 to 11.31,P<0.01).Conclusion The therapeutic efficacies of MSCs in rats with myocardid infarction become increasing apparent as time advances since 2 weeks after injection.
基金Project(N2018G034)supported by China Railway Corporation。
文摘The comparative research on the seismic performance of grouted sleeve connected pier(GS)and prestressed precast segmental concrete pier(PC)is mostly carried out by numerical simulation.In this study,the GS pier and the PC pier of the new railway project from Hetian to Ruoqiang are taken into consideration.Two kinds of 1/5-scale assembled double-column specimens are made,and the quasi-static tests are carried out.The overall seismic performance of the two spliced piers is studied,and compared in terms of failure mechanism,bearing capacity,ductility,stiffness and energy dissipation capacity.The results show that the failure modes of both GS pier and PC pier are characterized by bending.However,the specific failure location and form are different.The GS pier presents a complete hysteretic curve,large equivalent stiffness and strong energy dissipation capacity.The hysteretic area of the PC pier is small.However,it has good self-reset ability and quasi-static residual displacement.Finite element models are set up using DispBeamColumn fiber elements and ZeroLength elements.The models that are calibrated with the test data can effectively simulate the damage development under monotonic loading.The load−displacement curves are in good agreement with the backbone curves of the test results.
基金Supported by Young Teacher Foundation of Tianjin University (5110105) and Aeronautic Science Foundation (03H53048).
文摘The deformation behavior of hot isostatic pressing (HIP) FGH96 superalloy was characterized in the temperature range of 1000-1100 ℃ and strain rate range of 0. 001-0. 1 s^-1 using hot compression testing. The flow curves of HIP FGH96, superalloy during hot deformation was analyzed systematically. The results show that deformation temperature, strain rate and strain are the main influence factors on flow stress of HIP FGH96 superalloy during hot deformation. The flow stress displays a peak at a critical strain and then decreases with further increase in strain. For a given strain, the flow stress decreases with the increase of deformation temperature, and increases with the increase of strain rate. A mathematical model of these flow curves was established through regression analysis and taking the strain as a modification factor. The calculated stress values agree well with the experimental values.
文摘Portal hypertension can be caused by a wide variety of conditions.It frequently presents with bleeding from esophageal varices.The approach to acute variceal hemorrhage in children is a stepwise progression from least invasive to most invasive.Management of acute variceal bleeding is straightforward.But data on primary prophylaxis and long term management prevention of recurrent variceal bleeding in children is scarce,therefore prospective multicenter trials are needed to establish best practices.