Objective:The aim of the study was to evaluate the responses and toxicities of liposome encapsulated paclitaxel (LEP) plus cisplatin (DDP) (LP regimen) and paclitaxel (TAX) plus DDP (TP regimen) in the treatment of ad...Objective:The aim of the study was to evaluate the responses and toxicities of liposome encapsulated paclitaxel (LEP) plus cisplatin (DDP) (LP regimen) and paclitaxel (TAX) plus DDP (TP regimen) in the treatment of advanced non-small cell lung cancer (NSCLC). Methods: A total of 89 cases with advanced NSCLC was randomized into two groups: the LP group (57 patients) and the TP group (32 patients). The responses, toxicities and survivals of the two groups were compared. Results: The response rates were 40.00% and 38.71% in the LP and TP groups respectively, but no significant difference was detected between them (P>0.05). The median times to progression (TTP), median remission times, median survival times and 1-year survival rates were 18 weeks, 20 weeks, 35 weeks and 35.09% in the LP group, and 17 weeks, 18 weeks, 31 weeks and 28.15% in the TP group, respectively, and no significant differences were detected between them (P>0.05). The incidence of grades I-II peripheral neuritis in the TP group (37.50%) was significantly higher than that in the LP group (19.29%) (P<0.05). The incidence of grades I-II allergic reaction in the TP group (12.50%) was significantly higher than that in the LP group (5.26%) (P<0.05). And the incidence of grades Ⅲ-IV nausea/vomiting in the TP group (15.63%) was significantly higher than that in the LP group (5.26%) (P<0.01), too. Conclusion: The effect of LP regimen is similar to that of TP regimen, but the incidences of peripheral neuritis, allergic reaction and nausea/vomiting in LP regimen are lower than those in TP regimen. In short, LP regimen may be the first-line chemotherapy regimen of advanced NSCLC.展开更多
诗有各种形式,并泛称为诗歌。其理由,一则是不少诗可歌可咏,二则是诗本源于歌,诗的早期形式——歌谣,绝大多数是流传于民间的山歌小调。汉诗如此,英诗也不例外。如: The King sits in Dunfermline town Drinking the blude-red wine; ’...诗有各种形式,并泛称为诗歌。其理由,一则是不少诗可歌可咏,二则是诗本源于歌,诗的早期形式——歌谣,绝大多数是流传于民间的山歌小调。汉诗如此,英诗也不例外。如: The King sits in Dunfermline town Drinking the blude-red wine; ’O whare will I get a skeely skipper To sail this new ship o’mine? 这几行诗原是流传于苏格兰之南、英格兰以北接壤地区的民谣。其中Dunfermline是古代苏格兰的首府,blude(blood),whare(where),skeely(skilful)都是古体词。展开更多
Objective:The aim of our study was to investigate the value of dynamic contrast-enhanced MRI for evaluating differential diagnosis of pulmonary isolated lesions. Methods: Twenty-nine consecutive patients enrolled in t...Objective:The aim of our study was to investigate the value of dynamic contrast-enhanced MRI for evaluating differential diagnosis of pulmonary isolated lesions. Methods: Twenty-nine consecutive patients enrolled in this study,all of whom underwent DCE-MRI examinations and received a histologic and clinical diagnosis. Among these,lung tuberculoma 7 cases,harmatoma 3 cases,peripheral lung cancer 19 cases. DCE-MRI was acquired with 3D LAVA technique,total 18 phases were acquired,scanner time of per phase was 5–7″. After contrasting agent,twice successive scanning was acquired at 10″ and 50″. Then 1′30″,2′,2′30″,3′,3′30″,4′,5′,6′,7′,8′,9′,10′,11′,12′ performed scanning. Region of interest was placed on the Maximum level in the tumors. According to Schaefer’s standard,four types of time signal intensity curve (TIC) were classified,which were A,B,C and D. Compared the dynamic parameters between benign and malignant nodules. Results:Lung tuberculoma may display three curves: A type 1 case,ring-shaped enhancement 4 cases (periphery ring A type,central region D type),D type 2 cases. Harmatoma may display three curves: A type 1 case,C type 2 case. Peripheral lung cancer may display A type. Except 2 cases D type lung tuberculoma,we compared curve data of 8 cases benign nodules (including tuberculoma A type and periphery ring A type,harmatoma A type and C type) and lung cancer. SIEP%: benign nodules 0.7885 ± 0.5543,lung cancer 1.2623 ± 0.3059,P < 0.05; MER: benign nodules 1.0007 ± 0.4251,lung cancer 1.3694 ± 0.2740,P < 0.05; washout:P > 0.05. Conclusion:Lung MR imaging is helpful to diagnosis and differential diagnosis of isolated benign and malignant nodules. SIEP% and MER could offer valuable information. The evolution of global tuberculosis may be from A type to ring-shaped ennoblement to D type. It was easy to do right diagnosis to lung tuberculoma with ring-shaped ennoblement and D type. Peripheral lung cancer commonly displayed A type and needed identification with acute inflammation. So,it is important to anti-inflammatory follow-up for a few A type nodules.展开更多
文摘Objective:The aim of the study was to evaluate the responses and toxicities of liposome encapsulated paclitaxel (LEP) plus cisplatin (DDP) (LP regimen) and paclitaxel (TAX) plus DDP (TP regimen) in the treatment of advanced non-small cell lung cancer (NSCLC). Methods: A total of 89 cases with advanced NSCLC was randomized into two groups: the LP group (57 patients) and the TP group (32 patients). The responses, toxicities and survivals of the two groups were compared. Results: The response rates were 40.00% and 38.71% in the LP and TP groups respectively, but no significant difference was detected between them (P>0.05). The median times to progression (TTP), median remission times, median survival times and 1-year survival rates were 18 weeks, 20 weeks, 35 weeks and 35.09% in the LP group, and 17 weeks, 18 weeks, 31 weeks and 28.15% in the TP group, respectively, and no significant differences were detected between them (P>0.05). The incidence of grades I-II peripheral neuritis in the TP group (37.50%) was significantly higher than that in the LP group (19.29%) (P<0.05). The incidence of grades I-II allergic reaction in the TP group (12.50%) was significantly higher than that in the LP group (5.26%) (P<0.05). And the incidence of grades Ⅲ-IV nausea/vomiting in the TP group (15.63%) was significantly higher than that in the LP group (5.26%) (P<0.01), too. Conclusion: The effect of LP regimen is similar to that of TP regimen, but the incidences of peripheral neuritis, allergic reaction and nausea/vomiting in LP regimen are lower than those in TP regimen. In short, LP regimen may be the first-line chemotherapy regimen of advanced NSCLC.
文摘诗有各种形式,并泛称为诗歌。其理由,一则是不少诗可歌可咏,二则是诗本源于歌,诗的早期形式——歌谣,绝大多数是流传于民间的山歌小调。汉诗如此,英诗也不例外。如: The King sits in Dunfermline town Drinking the blude-red wine; ’O whare will I get a skeely skipper To sail this new ship o’mine? 这几行诗原是流传于苏格兰之南、英格兰以北接壤地区的民谣。其中Dunfermline是古代苏格兰的首府,blude(blood),whare(where),skeely(skilful)都是古体词。
文摘Objective:The aim of our study was to investigate the value of dynamic contrast-enhanced MRI for evaluating differential diagnosis of pulmonary isolated lesions. Methods: Twenty-nine consecutive patients enrolled in this study,all of whom underwent DCE-MRI examinations and received a histologic and clinical diagnosis. Among these,lung tuberculoma 7 cases,harmatoma 3 cases,peripheral lung cancer 19 cases. DCE-MRI was acquired with 3D LAVA technique,total 18 phases were acquired,scanner time of per phase was 5–7″. After contrasting agent,twice successive scanning was acquired at 10″ and 50″. Then 1′30″,2′,2′30″,3′,3′30″,4′,5′,6′,7′,8′,9′,10′,11′,12′ performed scanning. Region of interest was placed on the Maximum level in the tumors. According to Schaefer’s standard,four types of time signal intensity curve (TIC) were classified,which were A,B,C and D. Compared the dynamic parameters between benign and malignant nodules. Results:Lung tuberculoma may display three curves: A type 1 case,ring-shaped enhancement 4 cases (periphery ring A type,central region D type),D type 2 cases. Harmatoma may display three curves: A type 1 case,C type 2 case. Peripheral lung cancer may display A type. Except 2 cases D type lung tuberculoma,we compared curve data of 8 cases benign nodules (including tuberculoma A type and periphery ring A type,harmatoma A type and C type) and lung cancer. SIEP%: benign nodules 0.7885 ± 0.5543,lung cancer 1.2623 ± 0.3059,P < 0.05; MER: benign nodules 1.0007 ± 0.4251,lung cancer 1.3694 ± 0.2740,P < 0.05; washout:P > 0.05. Conclusion:Lung MR imaging is helpful to diagnosis and differential diagnosis of isolated benign and malignant nodules. SIEP% and MER could offer valuable information. The evolution of global tuberculosis may be from A type to ring-shaped ennoblement to D type. It was easy to do right diagnosis to lung tuberculoma with ring-shaped ennoblement and D type. Peripheral lung cancer commonly displayed A type and needed identification with acute inflammation. So,it is important to anti-inflammatory follow-up for a few A type nodules.
