African artists demonstrate social commitment and sensibility in various ways as they create works that both sensitise and conscientise people in their milieu. Although ecocriticism itself is a relatively new theory, ...African artists demonstrate social commitment and sensibility in various ways as they create works that both sensitise and conscientise people in their milieu. Although ecocriticism itself is a relatively new theory, African artists have been preoccupied with issues bothering around environment in order to protect and preserve it. ljala genre has been studied by different scholars such as Babalola S. A. （1966）, Olukoju E. O. （1978） and Alagbe ＇Sayo （2007） from diverse perspectives; however, its ecocritical relevance has not been investigated. It is in view of the foregoing that this paper carries out an ecocritical reading of ljala chant： an example of Ogundare Foyanmu＇s selected ljala chant. The paper aims at establishing environmental consciousness in the work of this oral artist. It is observed that though ecocritical theory itself is new in African literature, African artists have shown commitment towards environmental protection in their works from time immemorial. Foyanmu conscientises the people to desist from sneeringly underrating the effect of water hazard. The paper, therefore, has no doubt, established that the subject ofljala genre is not in any way limited to hunting or hunters＇ life. It is also used to address other relevant socio-political and economic issues展开更多
To compare the efficacy and safety of fidaxomicin and vancomycin for the treatment of patients with Clostridium difficile infection （CD1）, randomized controlled trials （RCTs） of fidaxomicin versus vancomycin for t...To compare the efficacy and safety of fidaxomicin and vancomycin for the treatment of patients with Clostridium difficile infection （CD1）, randomized controlled trials （RCTs） of fidaxomicin versus vancomycin for the treatment of CDI published in Pubmed, Embase, Web of Science and the Cochrane library were searched. Two reviewers independently extracted the data. The primary outcome was the rates of clinical cure. The secondary endpoints were the rates of CDI recurrence in the 4 weeks period after the end of therapy and rates of global cure, adverse events. Meta-analysis was performed using the Mantle-Haenszel fixed effect method （FEM）. Odds ratios （ORs） with 95% confidence intervals （95% CIs） were reported. The results indicated that two large randomized controlled trials were included in the meta-analysis. Clinical cure with fidaxomicin was similar to with vancomycin both in the modified intention to treat （OR = 1.17, 95% CI 0.82-1.66, P = 0.40） and in the per-protocol population （OR = 1.24, 95% CI 0.80-1.92, P = 0.34）. There were no significant differences in the rates of clinical cure between fidaxomicin and vancomycin in the subgroups analyzed by age, patients＇ status, and previous CDI, infection with B 1 strain, severity baseline, and exposure to concomitant antibiotics. Recurrence of CDI was significantly less common among fidaxomicin-treated patients compared with vancomycin-treated patients both in the modified intention-to-treat population （OR = 0.47, 95% CI 0.34-0.65, P〈0.00001） and in the per-protocol population （OR = 0.45, 95% CI 0.31-0.62, P〈0.0001）. Treatment with fidaxomicin compared with vancomycin was associated with significantly higher rates of global cure both in the modifed intention-to-treat population （OR = 1.75, 95% CI 1.35-2.27, P〈0.0001） and in the per-protocol population （OR = 1.86, 95% CI 1.40-2.47, P〈0.0001）. Our recta-analysis suggests that fidaxomicin is not superior to vancomycin in rates of clinical cure, while fidaxomicin significantly decreases the rates of CDI recurrence and significantly improves the rates of global cure compared with vancomycin. Thus, fidaxomicin is a promising candidate for treatment of the CDI, especially in decreasing the rates of CDI recurrence and improving the rates of global cure.展开更多
In this paper, we prove the global existence and uniqueness of non-negative classical solutions of the Smoluchowski equation with viscosity ε>0. The existence of weak solutions when ε=0 is also obtained.
文摘African artists demonstrate social commitment and sensibility in various ways as they create works that both sensitise and conscientise people in their milieu. Although ecocriticism itself is a relatively new theory, African artists have been preoccupied with issues bothering around environment in order to protect and preserve it. ljala genre has been studied by different scholars such as Babalola S. A. （1966）, Olukoju E. O. （1978） and Alagbe ＇Sayo （2007） from diverse perspectives; however, its ecocritical relevance has not been investigated. It is in view of the foregoing that this paper carries out an ecocritical reading of ljala chant： an example of Ogundare Foyanmu＇s selected ljala chant. The paper aims at establishing environmental consciousness in the work of this oral artist. It is observed that though ecocritical theory itself is new in African literature, African artists have shown commitment towards environmental protection in their works from time immemorial. Foyanmu conscientises the people to desist from sneeringly underrating the effect of water hazard. The paper, therefore, has no doubt, established that the subject ofljala genre is not in any way limited to hunting or hunters＇ life. It is also used to address other relevant socio-political and economic issues
文摘To compare the efficacy and safety of fidaxomicin and vancomycin for the treatment of patients with Clostridium difficile infection （CD1）, randomized controlled trials （RCTs） of fidaxomicin versus vancomycin for the treatment of CDI published in Pubmed, Embase, Web of Science and the Cochrane library were searched. Two reviewers independently extracted the data. The primary outcome was the rates of clinical cure. The secondary endpoints were the rates of CDI recurrence in the 4 weeks period after the end of therapy and rates of global cure, adverse events. Meta-analysis was performed using the Mantle-Haenszel fixed effect method （FEM）. Odds ratios （ORs） with 95% confidence intervals （95% CIs） were reported. The results indicated that two large randomized controlled trials were included in the meta-analysis. Clinical cure with fidaxomicin was similar to with vancomycin both in the modified intention to treat （OR = 1.17, 95% CI 0.82-1.66, P = 0.40） and in the per-protocol population （OR = 1.24, 95% CI 0.80-1.92, P = 0.34）. There were no significant differences in the rates of clinical cure between fidaxomicin and vancomycin in the subgroups analyzed by age, patients＇ status, and previous CDI, infection with B 1 strain, severity baseline, and exposure to concomitant antibiotics. Recurrence of CDI was significantly less common among fidaxomicin-treated patients compared with vancomycin-treated patients both in the modified intention-to-treat population （OR = 0.47, 95% CI 0.34-0.65, P〈0.00001） and in the per-protocol population （OR = 0.45, 95% CI 0.31-0.62, P〈0.0001）. Treatment with fidaxomicin compared with vancomycin was associated with significantly higher rates of global cure both in the modifed intention-to-treat population （OR = 1.75, 95% CI 1.35-2.27, P〈0.0001） and in the per-protocol population （OR = 1.86, 95% CI 1.40-2.47, P〈0.0001）. Our recta-analysis suggests that fidaxomicin is not superior to vancomycin in rates of clinical cure, while fidaxomicin significantly decreases the rates of CDI recurrence and significantly improves the rates of global cure compared with vancomycin. Thus, fidaxomicin is a promising candidate for treatment of the CDI, especially in decreasing the rates of CDI recurrence and improving the rates of global cure.
基金This research is supported by the National Natural Science Foundation of China
文摘In this paper, we prove the global existence and uniqueness of non-negative classical solutions of the Smoluchowski equation with viscosity ε>0. The existence of weak solutions when ε=0 is also obtained.
