期刊文献+
共找到3篇文章
< 1 >
每页显示 20 50 100
非-AIDS免疫抑制患者的呼吸系统问题
1
作者 PaulACorris 《国际内科双语杂志(中英文)》 2002年第6期69-73,共5页
随着器官移植及恶性肿瘤化疗的发展,免疫抑制患者的数量上升,这使患者的呼吸系统病变日益成为一个亟待解决的问题。HIV阳性者也有发生肺部机会性感染的危险。诊断包括感染性和非感染性疾病,以感染性疾病更常见。免疫抑制患者发生肺... 随着器官移植及恶性肿瘤化疗的发展,免疫抑制患者的数量上升,这使患者的呼吸系统病变日益成为一个亟待解决的问题。HIV阳性者也有发生肺部机会性感染的危险。诊断包括感染性和非感染性疾病,以感染性疾病更常见。免疫抑制患者发生肺部感染的危险性主要由2个因素决定。 展开更多
关键词 -AIDS免疫抑制 呼吸系统 器官移植 化疗 肺部感染 流行病学 免疫缺陷 细胞免疫 X线检查 CT 微生物学检查 病原体 非感染性肺病
下载PDF
Respiratory Problems in Non-AIDS Immunosuppressed Patients
2
作者 PaulACorris 《国际内科双语杂志(中英文)》 2002年第6期18-22,共5页
Respiratory problens in immunosuppressde patients present an increasing problen as the number of immunocompromised individuals increases with developments in organ transplantation and chemotherapy for malignant disease.
关键词 -AIDS免疫抑制 呼吸系统 器官移植 化疗 肺部微生物学检查 病原体 非感染性肺病
下载PDF
Establishment of animal model for potency evaluationof inactivated SARS virus experimental vaccine
3
作者 GUANMUDONG QIAN +9 位作者 YANKONG WENXUELIU LIHINGYANG JUNZHIWANG YONGXINYU YAOLONGSHU ZHENGWANG WEIDONGYIN QINGYUZHU HAIFAZHENG 《Journal of Microbiology and Immunology》 2005年第1期53-60,共8页
The purpose of this study was to test the effectiveness of source virus strain for the manufacture of the inactivated SARS virus vaccine, and establish an experimental method and preliminary standard for potency evalu... The purpose of this study was to test the effectiveness of source virus strain for the manufacture of the inactivated SARS virus vaccine, and establish an experimental method and preliminary standard for potency evaluation. Mice were divided into groups for being immunized with corresponding serially diluted experimental SARS virus inactivated vaccine. And the rabbits were immunized with undiluted vaccine. Challenge assay was conducted with a heterologous SARS virus. And the neutralization antibody was determined with plaque reduction neutralization test (PRNT), to which the neutralization antibody in the convalescent serum of SARS patients was compared. The experimental vaccine viral strains were proved to be suitable for manufacturing the vaccine. Mice immunized by vaccines of serial dilutions were able to elicit neutralizing antibody. The antibody titer from mice immunized with the undiluted vaccine could reach up to 1∶495.2, while those of rabbits immunized with the undiluted vaccine could reach a GMT of 55.0-79.9. The capability of the antibody to neutralize the virus from Guangdong is more efficient than that from Beijing. The GMT of neutralizing antibody in SARS convalescents living in south and north China ranged from 50.12 to 54.95, and the titers of convalescents from north China were higher than those from south China. Mice and rabbits used as the model for evaluation of potency are of sensitivity, and the test is of reproducibility. The candidate challenge viral strains showed a relatively consistent effect on evaluating antibodies produced by various batches and different vaccine-source strains, hence they can be used to evaluate potency of the vaccine. The method for testing the vaccine potency and the evaluation standard was established preliminarily. 展开更多
关键词 SARS virus Inactivated vaccine Neutralizing antibody Potency assay Plaque reduction neutralization test(PRNT)
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部