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非注射多肽类药开发研究进展
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作者 吴玉柱 《黑龙江医药》 CAS 2023年第1期159-162,共4页
目前多肽药物给药方式大部分为注射给药,需要长期注射的药物给患者带来恐惧和局疼痛,降低了患者的顺应性。开发非注射给药方式成为多肽药物研究的热点。本文对非注射多肽类药物的开发研究进展作一综述。
关键词 多肽类药物 非注射方法 研究进展
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Simulation of Non-isothermal Injection Molding for a Non-Newtonian Fluid by Level Set Method 被引量:8
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作者 杨斌鑫 欧阳洁 +1 位作者 刘春太 李强 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2010年第4期600-608,共9页
A non-isothermal injection molding process for a non-Newtonian viscous pseudoplastic fluid is simulated.A conservative interface capturing technique and the flow field solving method are coupled to perform a dynamic s... A non-isothermal injection molding process for a non-Newtonian viscous pseudoplastic fluid is simulated.A conservative interface capturing technique and the flow field solving method are coupled to perform a dynamic simulation.The validity of the numerical method is verified by a benchmark problem.The melt interface evolution versus time is captured and the physical quantities such as temperature,velocity and pressure at each time step are obtained with corresponding analysis.A"frozen skin"layer with the thickness increasing versus time during the injection process is found.The fact that the"frozen skin"layer can be reduced by increasing the injection velocity is numerically verified.The fountain flow phenomenon near the melt interface is also captured.Moreover,comparisons with the non-isothermal Newtonian case show that the curvatures of the interface arcs and the pressure contours near the horizontal mid-line of the cavity for the non-Newtonian pseudoplastic case is larger than that for the Newtonian case.The velocity profiles are different at different positions for the non-Newtonian pseudoplastic case,while in the case of Newtonian flow the velocity profiles are parabolic and almost the same at different positions. 展开更多
关键词 injection molding Level Set Method two-phase flow NON-ISOTHERMAL non-Newtonian flow
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