阿奇霉素联合阴道栓剂治疗非淋菌性宫颈炎的效果

目的:研究分析阿奇霉素联合阴道栓剂治疗非淋菌性宫颈炎的临床效果。方法:以本院2019年4月至2020年5月收治的71例非淋菌性宫颈炎患者为研究对象,以抛掷硬币的方法将所有患者分为对照组与观察组,其中对照组35例,观察组为36例。其中对照组应用阿奇霉素进行治疗,观察组在此基础之上加用阴道栓剂进行治疗,对比两组患者之间的阴道排液时间、宫颈的修复时间、不良反应发生情况以及治疗后血清炎性因子及免疫球蛋白的水平。结果:经治疗,观察组阴道排液时间、宫颈修复时间均短于对照组,P<0.05;经治疗,观察组出现不良反应的概率低于对照组,P<0.05;经治疗,观察组IL-4、PGE_(2)以及TNF-α的水平数值均低于对照组,P<0.05。结论:将阿奇霉素与阴道栓剂进行联合应用之后,非淋菌性宫颈炎患者的临床症状得到了有效的控制,不良反应的发生概率也更低,患者的炎症消退速度更快。

非淋菌非衣原体性宫颈炎生殖支原体感染的检测

目的了解非淋菌非衣原体性宫颈炎(NGNCC)生殖支原体(Mg)感染状况并分析两者的相关性。方法采用现况研究法对158例NGNCC患者、98例非NGNCC性病门诊女性就诊者及94例健康女性进行问卷调查,并采用培养及两种PCR方法对三组人群宫颈分泌物进行Mg分离和检测。结果158例NGNCC中16例(10.13%)Mg阳性,98例非NGNCC性病门诊女性就诊者中3例(3.06%)Mg阳性,94例健康女性未检出Mg,NGNCC组Mg感染率与其他各组差异均有显著性(P<0.05)。350例受检者分为Mg阳性组和阴性组,经多因素Logistic分析,性伴数(OR=5.542,95%CI1.945～15.787)、性生活频率(OR=5.382,95%CI1.881～15.398)及既往宫颈炎史(OR=5.824,95%CI1.923～17.643)与Mg感染相关。结论NGNCC患者中存在Mg感染,Mg可能是NGNCC的致病因素之一。

阿奇霉素联合阴道栓剂治疗非淋菌性宫颈炎临床效果

目的:非淋菌宫颈炎应用阿奇霉素与阴道栓剂联合治疗效果情况分析。方法:选取2018年7月至2019年7月本院诊治的90例非淋菌宫颈炎患者资料,随机分为两组,对照组予阿奇霉素,研究组予阿奇霉素与阴道栓剂联合方案,分析两组相关临床症状改善时间及不良反应情况。结果:治疗后,研究组下腹痛消失时间(2.12±1.06)d、尿痛消失时间(2.63±1.36)d、白带恢复正常时间(6.10±1.15)d均比对照组少,差异具有统计学意义(P<0.05);且研究组呕吐恶心、腹胀等不良反应发生率6.67%比对照组的26.67%低,差异具有统计学意义(P<0.05)。结论:非淋菌宫颈炎应用阿奇霉素与阴道栓剂联合治疗,能有效缩短患者临床症状改善时间,且不良反应比较少,具有安全性,有一定的临床应用价值。

Analysis of Culture and Drug Sensitivity Tests of Mycoplasmas for 387 Patients with Nongonococcal Urethritis (Cervicitis) in Chongqing

Objective: To investigate the prevalence of myco-plasma infections and the sensitivity to antibiotics among patients with nongonococcal urethritis or cer-vicitis (NGU) in Chongqing. Methods: 387 NGU cases with mycoplasma-positive results upon culture were analysed retrospectively. RESULTS: The majority of patients with mycoplasma infections were in the 20-40 year old age group. No significant difference was found between males and females. Ureaplasma urealyticum is the main pathogen of these NGU cases and no clear relationship between its concentration and pathogenic ability was noted. Drug sensitivity was tested against nine antibiotics; the sensitivity rates to josamycim, minocycline and doxycycline were 94.06%, 88.89% and 86.82% respectively, while the resistance rates to lincomycin, ofloxacin, azithromycin and roxthromycin were 74.94%, 42.12%, 41.60% and 40.31% in turn. Conclusions: Josamycin, minocycline and doxycycline could be used as the first choice to treat NGU with mycoplasma infections in Chongqing. It is important to select antibiotics for NGU treatment with mycoplasma infections based on the results of drug sensitivity tests.

Efficacy Study on Six Antibiotic Methods for Treating Non-Gonococcal Urethritis and Cervicitis

Objective： To analyze the efficacy of six antibiotic methods for treating non- gonococcal urethritis /cervicitis and the factors influencing efficacy. Methods： Retrospective analysis of 878 nongonococcal urethritis / cervicitis cases which received regular treatment and follow-up in our institute from 1st Jan. 2001 to 31st Aug. 2003. Results： The mean cure rate of six methods for Chlamydia trachamatis （Ct） was 57.116%. There were distinct differences among these methods for Ct treatment.The mean cure rate of six methods for Ureaplasma urealyticum （Uu） was 69.556% and there was no difference among these methods for Uu treatment. Coinfection with Ct and Uu dramatically reduced the elimination rate of these two pathogens. Conclusion： The effectiveness of treatment of these antibodies for non-gonococcal urethritis / cervicitis is not currently satisfactory. Importantly, there were many antibiotic-resistant Ct and Uu strains. The factors influencing antibiotic efficacy and mechanisms need further study.