IN SITU IMAGING OF BREAST CANCER CELLS USING GREEN SEMICONDUCTOR QUANTUM DOTS

The breast cancer is the most common cause of cancer death in women. To establish an early stage in situ imaging of breast cancer cells, green quantum dots （QDs） are used as a fluorescent signal generator. The QDs based imaging of breast cancer cells involves anti-HER2/neu antibody for labeling the over expressed HER2 on the surface of breast cancer cells. The complete assay involves breast cancer cells, biotin labeled antibody and streptavidin conjugated QDs. The breast cancer cells are grown in culture plates and exposed to the biotin labeled antibodies, and then exposed to streptavidin labeled QDs to utilize the strong and stable biotin-streptavidin interaction. Fluorescent images of the complete assay for breast cancer cells are evaluated on a microscope with a UV light source. Results show that the breast cancer cells in the complete assay are used as fluorescent cells with brighter signals compared with those labeled by the organic dye using similar parameters and the same number of cells.

Self-heating tendency evaluation of sulfide ores based on nonlinear multi-parameters fusion

In order to reveal the nonlinear dynamics characteristics of unsteady self-heating process of sulfide ores, nine different kinds of sulfide ore samples from a pyrite mine in China were taken as experimental materials and their self-heating characteristics were measured in laboratory. Furthermore, the measured temperature was studied by integrating wavelet transform, nonlinear characteristic parameters extraction and fuzzy comprehensive evaluation. The results indicate that only the ore samples 1, 2, 6 and 9 have obvious self-heating phenomenon, and their self-heating initiative temperatures are 220 ℃, 239 ℃, 220 ℃ and 220 ℃, respectively, which means that they are difficult to produce self-heating under normal mining conditions. The correlation dimension of self-heating process is fraction and the maximum Lyapunov exponent is positive, which means that it is feasible to study the self-heating process based on chaotic dynamics theory. The nonlinearities of self-heating process of these four samples （ore samples 1, 2, 6 and 9） are 0.8227, 0.7521, 0.9401 and 0.8827 respectively and the order of the samples according to these results is： sample 6, sample 9, sample 1, sample 2, which is consistent with the measured results of self-heating characteristics. Therefore, the nonlinearity method can be used to evaluate the self-heating tendency of sulfide ores, and it is an effective verification of the reliability of measured results.

Effects of Heavy Metal and Pollutants on the Non-special Immunity of the Shrimp and Crab

This paper attempted to review and evaluate existing information about the effects of heavy metal, ammonia-N, nitrite and the organic pollutants on the non-special immune response of the shrimp and crab, which providing theory for improving the self-immunity of shrimp and crab by meliorating cultural environment. In addition, it could provide information for further study on this field.

Wind tunnel test for wind pressure characteristics on a saddle roof

The wind pressure characteristics on a saddle roof at wind direction along the connection of the low points are systematically studied by the wind tunnel test. First, the distributions of the mean and the fluctuating pressures on the saddle roof are provided. Through the wind pressure spectra, the process of generation, growth and break down of the vortex on the leading edge is presented from a microscopic aspect and then the distribution mechanism of the mean and fluctuating pressures along the vulnerable leading edge is explained. By analysis of the wind pressure spectra near the high points, it can be inferred that the body induced turbulence reflects itself as a high-frequency pressure fluctuation. Secondly, the third-and fourth-order statistical moments of the wind pressure are employed to identify the non-Gaussian nature of the pressure time history and to construct an easy tool to localize regions with a non-Gaussian feature. The cause of the non-Gaussian feature is discussed by virtue of the wind pressure spectra. It is concluded that the non-Gaussian feature of the wind pressure originates from the effects of flow separation and body-induced turbulence, and the former effect plays an obvious role.

Nonlinear static characteristics of piezoelectric unimorph bending micro actuators

The nonlinear static characteristic of a piezoelectric unimorph cantilever micro actuator driven by a strong applied electric field is studied based on the couple stress theory.The cantilever actuator consists of a piezoelectric layer,a passive（elastic）layer and two electrode layers.First,the nonlinear static characteristic of the actuator caused by the electrostriction of the piezoelectric layer under a strong applied electric field is analyzed using the Rayleigh-Ritz method.Secondly,since the thickness of the cantilever beam is in micro scale and there exists a size effect,the size dependence of the deformation behavior is evaluated using the couple stress theory.The results show that the nonlinearities of the beam deflection increase along with the increase of the applied electric field which means that softening of the micro beam rigidity exists when a strong external electric field is applied.Meanwhile,the optimal value of the thickness ratio for the passive layer and the piezoelectric layer is not around 1.0 which is usually adopted by some previous researchers.Since there exists a size effect of the micro beam deflection,the optimal value of this thickness ratio should be greater than 1.0 in micro scale.

Modeling and Simulation of the Characteristics of Pneumatic Cushion Cylinders

The analysis of the characteristics of the cushion process of the pneumatic cushion cylinder is presented, and the nonlinear model of pneumatic cushion cylinders is built in the form of nonlinear differential equations. Besides, through the simulation of the pressure in the cushion chamber, the characteristics of the pneumatic cushion cylinder are obtained, which helps to understand the performance of the pneumatic cushion cylinder and improve or design the better cushion structure.

Analysis and design of sigma-delta interface circuit for quartz flexural pendulum accelerometer

For the high resolution required in a digital interface circuit of an accelerometer used in feeble gravity measurement, a switched-capacitor （SC） sigma-delta modulator （SDM） is proposed. Based on the principle and the topology structure of the SDMs, the influence of oversampling ratio, bits of an internal quantizer and the cascaded structure on weak signal detecting precision is analyzed, and an ideal low-distortion SDM with a second-order 1-bit structure satisfying the high- resolution interface circuit of an accelerometer is designed. With the research on non-idealities of each SDM block in the SC circuit implementation and their impacts on power consumption, the realized parameters of low-power SDMs based on different bandwidths are devised and the power consumption of each SDM is estimated. Time-domain behavioral simulation is explored based on Simulink. The results demonstrate that a 21- bit resolution of the designed SDMs can be achieved on the premise of low power, and the parameters for the circuit implementation can be directed to the transistor-level circuit design.

Local hierarchical non-negative tensor factorization and its application in machinery fault diagnosis

Aiming at the slow convergence and low accuracy problems of the traditional non-negative tensor factorization, a local hierarchical non-negative tensor factorization method is proposed by applying the local objective function theory to non- negative tensor factorization and combining the three semi-non- negative matrix factorization（NMF） model. The effectiveness of the method is verified by the facial feature extraction experiment. Through the decomposition of a series of an air compressor＇s vibration signals composed in the form of a bispectrum by this new method, the basis images representing the fault features and corresponding weight matrices are obtained. Then the relationships between characteristics and faults are analyzed and the fault types are classified by importing the weight matrices into the BP neural network. Experimental results show that the accuracy of fault diagnosis is improved by this new method compared with other feature extraction methods.

Sparseness-controlled non-negative tensor factorization and its application in machinery fault diagnosis

Aiming at the problems of bispectral analysis when applied to machinery fault diagnosis, a machinery fault feature extraction method based on sparseness-controlled non-negative tensor factorization （SNTF） is proposed. First, a non-negative tensor factorization（NTF） algorithm is improved by imposing sparseness constraints on it. Secondly, the bispectral images of mechanical signals are obtained and stacked to form a third-order tensor. Thirdly, the improved algorithm is used to extract features, which are represented by a series of basis images from this tensor. Finally, coefficients indicating these basis images＇ weights in constituting original bispectral images are calculated for fault classification. Experiments on fault diagnosis of gearboxes show that the extracted features can not only reveal some nonlinear characteristics of the system, but also have intuitive meanings with regard to fault characteristic frequencies. These features provide great convenience for the interpretation of the relationships between machinery faults and corresponding bispectra.

Learning compact binary code based on multiple heterogeneous features

A novel hashing method based on multiple heterogeneous features is proposed to improve the accuracy of the image retrieval system. First, it leverages the imbalanced distribution of the similar and dissimilar samples in the feature space to boost the performance of each weak classifier in the asymmetric boosting framework. Then, the weak classifier based on a novel linear discriminate analysis （LDA） algorithm which is learned from the subspace of heterogeneous features is integrated into the framework. Finally, the proposed method deals with each bit of the code sequentially, which utilizes the samples misclassified in each round in order to learn compact and balanced code. The heterogeneous information from different modalities can be effectively complementary to each other, which leads to much higher performance. The experimental results based on the two public benchmarks demonstrate that this method is superior to many of the state- of-the-art methods. In conclusion, the performance of the retrieval system can be improved with the help of multiple heterogeneous features and the compact hash codes which can be learned by the imbalanced learning method.

Nonlinear Current-Voltage Characteristics and Electroluminescence of cBN Crystal

The current-voltage（I-V） characteristics of cBN crystal sandwiched between two metallic electrodes are measured and found to be nonlinear. Over 20 samples are measured at room temperature with various electrodes, and the resulting curves are all similar in shape. When a voltage of about 560V is applied to the cBN crystal, the emitted light is visible to the naked eye in a dark room. We explain these phenomena by the space charge limited current and the electronic transition between the X and Г valleys of the conduction band.

1.3μm AlInGaAs Strained Single Quantum Well Laser Diodes with High Characteristic Temperature of 200K

A high characteristic temperature （T0） of 200K from a 1.3μm AlInGaAs/AlInAs single-quantum-well laser diode with the asymmetric waveguide layer structure under CW operation at 20 to 80℃ was obtained,which is the best result reported in the laser diodes （LDs） of the same active materials structure and emitting wave- length. AllnGaAs as an active layer,therefore,is very promising for the fabrication of long-wavelength LDs with excellent high-temperature performance. It is found that the asymmetric waveguide layer structure can decrease optical absorption and improve the high-temperature performance and catastrophic optical damage threshold of LDs.

Free dendritic growth model incorporating interfacial nonisosolutal nature due to normal velocity variation

Considering both the effects of the interfacial normal velocity dependence of solute segregation and the local nonequilibrium solute diffusion,an extended free dendritic growth model was analyzed.Compared with the predictions from the dendritic model with isosolutal interface assumption,the transition from solutal dendrite to thermal dendrite moves to higher undercoolings,i.e.,the region of undercoolings with solute controlled growth is extended.At high undercoolings,the transition from the mainly thermal-controlled growth to the purely thermal-controlled growth is not sharp as predicted by the isosolute model,but occurs in a range of undercooling,due to both the effects of the interfacial normal velocity dependence of solute segregation and the local nonequilibrium solute diffusion.Model test indicates that the present model can give a satisfactory agreement with the available experimental data for the Ni-0.7% B（mole fraction） alloy.

The MKdV Equation with Nonuniformity Terms

In this paper, the MKdV equation with nonuniformity terms is discussed. It relates to the eigenvalue problem The evolution laws of scattering data for (1. 3) are derived and the inverse scattering solutions-soliton solutions of eq(1. 1) are obtained. In the end of the paper, the single soliton solution and Double soliton solution are discussed. The result extends the situation in [1].

Priapism secondary to penile metastasis of rectal cancer

Metastatic penile carcinoma is rare and usually originates from genitourinary tumors. The presenting symptoms or signs have been described as nonspecific except for priapism. Rectal adenocarcinoma is a very unusual source of metastatic penile carcinoma. We report a case of metastatic penile carcinoma that originated from the rectum. Symptomatic improvement occurred with palliative radiotherapy.

Adamantiades-Behcet's disease-complicated gastroenteropathy

Adamantiades-Behcet's disease (ABD) is a chronic,relapsing,systemic vasculitis of unknown etiology.It is more prevalent in populations along the ancient Silk Road from Eastern Asia to the Mediterranean Basin,and most frequently affects young adults between the second and fourth decades of life.ABD-complicated gastroenteropathy is a significant cause of morbidity and mortality,with abdominal pain as the most common symptom.The ileocecal region is affected predominantly,with ulcerations that may lead to penetration and/or perforation,whereas other parts of the gastrointestinal system including the esophagus and stomach can also be affected.Endoscopy is useful to locate the site and extent of the lesions,and tissue biopsy is often warranted to examine the histopathology that is often suggestive of underlying vasculitis of small veins/venules or,alternatively in some cases,nonspecific inflammation.Bowel wall thickening is the most common finding on computed tomography scan.Treatment is largely empirical since well-controlled studies are difficult to conduct due to the heterogeneity of the disease,and the unpredictable course with exacerbation and remission.Corticosteroids with or without other immunosuppressive drugs,such as cyclophosphamide,azathioprine,sulfasalazine,tumor necrosis factor α antagonist or thalidomide should be applied before surgery,except in emergency.

Effects of Dietary β-Glucan and Glycyrrhizin on Non-Specific Immunity and Disease Resistance of the Sea Cucumber (Apostichopus japonicus Selenka) Challenged with Vibrio splendidus

Sea cucumbers, Apostichopus japonicus Selenka, were fed diets containing non-immunostimulant (basal diet), 0.2% β-glucan and 0.02% glycyrrhizin in a recirculatory water system for 45 days, and subsequently challenged with Vibrio splendidus by injection at 1.0×108 cfu/sea cucumber for 15 days.Phagocytic capacity (PC), intracellular superoxide anion production (ISAP), ly-sozyme (LSZ) activity and superoxide dismutase (SOD) activity in the coelomic fluid were analyzed on the 0th, 5th, 10th and 15th days after injection.Results showed that after the 45-day feeding period, PC, ISAP, LSZ activity and SOD activity in sea cucumbers fed with dietary β-glucan or glycyrrhizin were significantly higher than in those fed with the basal diet.On the 5th day after infection, all the immune parameters examined in the sea cucumbers injected with V.splendidus decreased in value significantly.On the 15th day, PC, ISAP and LSZ activity returned to levels similar to those on the 0th day.For the sea cucumbers injected with saline, there were no significant differences in all the immune parameters examined and in the cumulative morbidity during the 15-day challenging trial.After injecting with V.splendidus, the cumulative morbidity of sea cucumbers fed with the basal diet was significantly higher than those fed with dietary β-glucan or glycyrrhizin when challenged with V.splendidus challenged sea cucumber fed with the basal diet was significantly higher than those fed with dietary β-glucan or glycyrrhizin.There was no significant difference in cumulative morbidity between the dietary β-glucan and glycyrrhizin treatments over time.

Multifocal stenosing ulceration of the small intestine

Several reports have described an apparently uncommon clinicopathological disorder that is characterized by multifocal stenosing small-intestinal ulceration.Compared to Crohn's disease,the ulcers are not transmural and typically remain shallow,and involve only the mucosa and submucosa.The disorder seems to be localized in the jejunum and proximal ileum only,and not the distal ileum or colon.Only nonspecif ic inflammatory changes are present without giant cells or other typical features of granulomatous inflammation.Most patients present clinically with recurrent obstructive events that usually respond to steroids,surgical resection,or both.With the development of newer imaging modalities to visualize the small-intestinal mucosa,such as double-balloon enteroscopy,improved understanding of the long-term natural history of this apparently distinctive disorder should emerge.

Biliary cystadenoma

The diagnosis of cystadenoma is rare, even more so when located in the extrahepatic bile duct. Unspecific clinical signs may lead this pathology to be misdiagnosed. The need for pathological anatomy in order to distinguish cystadenomas from simple biliary cysts is crucial. The most usual treatment nowadays is resection of the bile duct, together with cholecystectomy and Roux-en-Y reconstruction.

Total colorectal and terminal ileal duplication presenting as intussusception and intestinal obstruction

Colonic intussusception and gastrointestinal duplication are diseases that arise in young children. The clinical presentation of adult cases of intussusception and enteric duplication is non-specific and thus poses a diagnostic challenge. A computed tomography (CT) scan is recommended in adult cases as the most sensitive diagnostic tool and the pathognomonic finding of outer intussuscepiens and central intussusceptum is diagnostic. A septum of a duplicated colon in a non-intussuscepted segment has been rarely reported in the literature. With advancements in radiological imaging technology and the increased availability of CT scanners, the capacity for a correct pre-operative diagnosis has been significantly enhanced. Our current case report illustrates the importance of considering an uncommon etiology for enteric intussusception and duplication as a differential diagnosis of acute abdomen in an adult patient. Our analyses of this patient also highlight the successful use of CT scanning to make this diagnosis.