Mg65Cu25Y10 bulk amorphous alloy specimens prepared by conventional copper mould method were heated at 200 °C for different time and the phase contents as well as microstructure were studied.The XRD results show ...Mg65Cu25Y10 bulk amorphous alloy specimens prepared by conventional copper mould method were heated at 200 °C for different time and the phase contents as well as microstructure were studied.The XRD results show that the crystallization of Mg65Cu25Y10 bulk amorphous alloy specimen becomes complete as the treating time increases and Mg2Cu,Mg24Y5 and HCP-Mg crystalline phases are found.Snowflake-like morphology is found in different specimens through SEM observation.The EDS patterns show that the composition of the snowflake-like structure is close to that of the as-cast alloy.Laminated structures are observed from the TEM images of the snowflake-like structure.From the electron diffraction patterns,it is seen that the snowflake-like structure is the combination of Mg24Y5 and amorphous matrix.The FCC-Mg phase in the matrix transforms into HCP-Mg during the heat-treating process.展开更多
OBJECTIVE This study was designed to assess E-cadherin (E-cad)and proliferating cell nuclear antigen(PCNA)expression as well as their clinicopathological significance in hunman non- small cell lung cancers(NSCLCs).Pos...OBJECTIVE This study was designed to assess E-cadherin (E-cad)and proliferating cell nuclear antigen(PCNA)expression as well as their clinicopathological significance in hunman non- small cell lung cancers(NSCLCs).Possible molecular mechanisms of differentiation and metastasis of NSCLCs are discussed. METHODS Immunohistochemical and immunofluorescence double staining were performed to examine the expression of E-cad and PCNA in 68 primary NSCLCs cases. RESULTS The E-cad expression in squamous cell carcinomas and adenocarcinomas showed no significant difference.E-cad expression had a positive correlation with the histological- differentiated grade.A significant difference of E-cad expression was found between metastatic and non-metastatic groups.PCNA expression in squamous cell carcinomas and adenocarcinomas showed no significant difference.The PCNA expression had a reverse correlation with the histological-differentiated grade.A significant difference of PCNA expression was found between metastatic and non-metastatic groups.The E-cad and PCNA expression presented a reverse correlation. CONCLUSION E-cad expression is not associated with the histological type of NSCLC,but is associated with differentiation and metastasis of the cancer.Down-regulation of E-cad expression affects the proliferation of cancer cells.Conjoint analysis of E-cad and PCNA expression is a good way to evaluate tumor biological behavior.展开更多
The effects of isothermal holding time on the semisolid microstructure of Mg-9Al-1Si(mass fraction,%)alloy were investigated.The research results indicate that the Mg-9Al-1Si alloy with non-dendritic microstructure ca...The effects of isothermal holding time on the semisolid microstructure of Mg-9Al-1Si(mass fraction,%)alloy were investigated.The research results indicate that the Mg-9Al-1Si alloy with non-dendritic microstructure can be produced by the semi-solid isothermal heat treatment.With holding time varying from 5 to 30 min,the volume fraction of liquid is gradually enlarged from 29.3%to 38.6%,the morphology ofα-Mg grains changes from initial dendritic shape to spherical types and their average sizes increases from 41.1 to 56.1μm.In addition,during the isothermal heat treatment,the eutectic Mg2Si phase changes from the initial Chinese script shape to granule and/or polygon shape in Mg-9Al-1Si alloy.The modification of Mg2Si phase is possibly attributed to a shift of the eutectic composition of the liquid in semi-solid slurries,towards lower silicon contents with increasing Al content due to a redistribution of Al during isothermal heat treatment.展开更多
Fingerlings of Nile tilapia Oreochromis niloticus were exposed to 1.68, 3.36, and 5.04 mg/L cadmium(as CdCl2), which represent 10%, 20%, and 30% of their previously determined 96-h LC5 0. After exposure for 20 days, s...Fingerlings of Nile tilapia Oreochromis niloticus were exposed to 1.68, 3.36, and 5.04 mg/L cadmium(as CdCl2), which represent 10%, 20%, and 30% of their previously determined 96-h LC5 0. After exposure for 20 days, sections of the liver and intestine of treated fish were examined histologically. Histopathological changes varied from slight to severe structural modification, depending on the exposure concentration. The hepatic tissues of fish exposed to 10% LC 50 showed markedly increased vacuolation of the hepatocytes and coarse granulation of their cytoplasm. Abundant erythrocytic infiltration among the hepatocytes was observed in fish exposed to 20% LC5 0. In the intestinal tissues of fish exposed to all doses, goblet cells proliferated and were greatly increased in size, the longitudinal muscularis mucosa was disturbed and, in the crypts of the sub-mucosal layer, apoptosis increased, indicated by large numbers of degenerated nuclei. Large numbers of inflammatory cells and dilated blood vessels were observed in the intestine of the group treated with 30% LC5 0.展开更多
基金Project (2008-04) supported by the Top Talent Plan of Jiangsu University, ChinaProject (10KJA430008) supported by the Natural Science Foundation of Jiangsu Higher Education Institutions,China
文摘Mg65Cu25Y10 bulk amorphous alloy specimens prepared by conventional copper mould method were heated at 200 °C for different time and the phase contents as well as microstructure were studied.The XRD results show that the crystallization of Mg65Cu25Y10 bulk amorphous alloy specimen becomes complete as the treating time increases and Mg2Cu,Mg24Y5 and HCP-Mg crystalline phases are found.Snowflake-like morphology is found in different specimens through SEM observation.The EDS patterns show that the composition of the snowflake-like structure is close to that of the as-cast alloy.Laminated structures are observed from the TEM images of the snowflake-like structure.From the electron diffraction patterns,it is seen that the snowflake-like structure is the combination of Mg24Y5 and amorphous matrix.The FCC-Mg phase in the matrix transforms into HCP-Mg during the heat-treating process.
文摘OBJECTIVE This study was designed to assess E-cadherin (E-cad)and proliferating cell nuclear antigen(PCNA)expression as well as their clinicopathological significance in hunman non- small cell lung cancers(NSCLCs).Possible molecular mechanisms of differentiation and metastasis of NSCLCs are discussed. METHODS Immunohistochemical and immunofluorescence double staining were performed to examine the expression of E-cad and PCNA in 68 primary NSCLCs cases. RESULTS The E-cad expression in squamous cell carcinomas and adenocarcinomas showed no significant difference.E-cad expression had a positive correlation with the histological- differentiated grade.A significant difference of E-cad expression was found between metastatic and non-metastatic groups.PCNA expression in squamous cell carcinomas and adenocarcinomas showed no significant difference.The PCNA expression had a reverse correlation with the histological-differentiated grade.A significant difference of PCNA expression was found between metastatic and non-metastatic groups.The E-cad and PCNA expression presented a reverse correlation. CONCLUSION E-cad expression is not associated with the histological type of NSCLC,but is associated with differentiation and metastasis of the cancer.Down-regulation of E-cad expression affects the proliferation of cancer cells.Conjoint analysis of E-cad and PCNA expression is a good way to evaluate tumor biological behavior.
基金Project(HEUFT05038)supported by the Basic Research Foundation of Harbin Engineering University,ChinaProject(2009AA03Z423)supported by the National High-Tech Research and Development Program of China
文摘The effects of isothermal holding time on the semisolid microstructure of Mg-9Al-1Si(mass fraction,%)alloy were investigated.The research results indicate that the Mg-9Al-1Si alloy with non-dendritic microstructure can be produced by the semi-solid isothermal heat treatment.With holding time varying from 5 to 30 min,the volume fraction of liquid is gradually enlarged from 29.3%to 38.6%,the morphology ofα-Mg grains changes from initial dendritic shape to spherical types and their average sizes increases from 41.1 to 56.1μm.In addition,during the isothermal heat treatment,the eutectic Mg2Si phase changes from the initial Chinese script shape to granule and/or polygon shape in Mg-9Al-1Si alloy.The modification of Mg2Si phase is possibly attributed to a shift of the eutectic composition of the liquid in semi-solid slurries,towards lower silicon contents with increasing Al content due to a redistribution of Al during isothermal heat treatment.
基金Supported by the Deanship of Scientific Research at King Saud University(No.RGP-VPP-304)
文摘Fingerlings of Nile tilapia Oreochromis niloticus were exposed to 1.68, 3.36, and 5.04 mg/L cadmium(as CdCl2), which represent 10%, 20%, and 30% of their previously determined 96-h LC5 0. After exposure for 20 days, sections of the liver and intestine of treated fish were examined histologically. Histopathological changes varied from slight to severe structural modification, depending on the exposure concentration. The hepatic tissues of fish exposed to 10% LC 50 showed markedly increased vacuolation of the hepatocytes and coarse granulation of their cytoplasm. Abundant erythrocytic infiltration among the hepatocytes was observed in fish exposed to 20% LC5 0. In the intestinal tissues of fish exposed to all doses, goblet cells proliferated and were greatly increased in size, the longitudinal muscularis mucosa was disturbed and, in the crypts of the sub-mucosal layer, apoptosis increased, indicated by large numbers of degenerated nuclei. Large numbers of inflammatory cells and dilated blood vessels were observed in the intestine of the group treated with 30% LC5 0.
