A non-linear non-ideal model, taking into account non-linear competitive isotherms, axial dispersion, film mass transfer, intraparticle diffusion, and port periodic switching, was developed to simulate the dynamics of...A non-linear non-ideal model, taking into account non-linear competitive isotherms, axial dispersion, film mass transfer, intraparticle diffusion, and port periodic switching, was developed to simulate the dynamics of simulated moving bed chromatography (SMBC). The model equations were solved by a new efficient numerical technique of orthogonal collocation on finite elements with periodical movement of concentration vector. The simulated SMBC performance is in accordance with the experimental results reported in the literature for separation of l,1'-bi-2-naphthol enantiomers using SMBC. This model is useful for design, operation, optimization and scale-up of non-linear SMBC for chiral separations with significant non-ideal effects, especially for high solute concentration and small intraparticle diffusion coefficient or large chiral stationary phase particle.展开更多
The paper proposes the identification method of linear and non-linear chromatographic system. Isotherms and lumped mass transfer coefficients of chromatography separating isomer sorbitol and mannitol on D80 adsorbent ...The paper proposes the identification method of linear and non-linear chromatographic system. Isotherms and lumped mass transfer coefficients of chromatography separating isomer sorbitol and mannitol on D80 adsorbent are determined. The analyses of root mean square error of chromatography elution curves are carried out. The results show that the system studied is non-linear and the theoretical elution curves of the non-linear chromatographic model are more accurate than those of the linear chromatographic model. Results of parameter sensitivity analyses show that elution curves of non-linear chromatographic separation are more sensitive to the variation of parameter "ai" in the adsorption isotherms than to the variation of parameter "bi" as well as lumped mass transfer coefficients.展开更多
基金Supported by the National Natural Science Foundation of China(No.20206027)and the Natural Science Foundation of Zhejiang Province(No.202046).
文摘A non-linear non-ideal model, taking into account non-linear competitive isotherms, axial dispersion, film mass transfer, intraparticle diffusion, and port periodic switching, was developed to simulate the dynamics of simulated moving bed chromatography (SMBC). The model equations were solved by a new efficient numerical technique of orthogonal collocation on finite elements with periodical movement of concentration vector. The simulated SMBC performance is in accordance with the experimental results reported in the literature for separation of l,1'-bi-2-naphthol enantiomers using SMBC. This model is useful for design, operation, optimization and scale-up of non-linear SMBC for chiral separations with significant non-ideal effects, especially for high solute concentration and small intraparticle diffusion coefficient or large chiral stationary phase particle.
文摘The paper proposes the identification method of linear and non-linear chromatographic system. Isotherms and lumped mass transfer coefficients of chromatography separating isomer sorbitol and mannitol on D80 adsorbent are determined. The analyses of root mean square error of chromatography elution curves are carried out. The results show that the system studied is non-linear and the theoretical elution curves of the non-linear chromatographic model are more accurate than those of the linear chromatographic model. Results of parameter sensitivity analyses show that elution curves of non-linear chromatographic separation are more sensitive to the variation of parameter "ai" in the adsorption isotherms than to the variation of parameter "bi" as well as lumped mass transfer coefficients.
