AIM: To determine the role of leptin system in non-al- coholic fatty liver disease (NAFLD) development by deli- neating the changes in serum levels of leptin and soluble leptin receptor (sOB-R). METHODS: Blood samples...AIM: To determine the role of leptin system in non-al- coholic fatty liver disease (NAFLD) development by deli- neating the changes in serum levels of leptin and soluble leptin receptor (sOB-R). METHODS: Blood samples were collected from 30 consecutive patients with liver-biopsy-proven NAFLD and 30 patients with cholecystolithiasis (stationary phase) as controls. Serum leptin levels were determined by radio- immunoassay and concentration of sOB-R was measured by ELISA. Body mass index (BMI) was calculated for all subjects, and serum insulin, C-peptide, and lipoprotein levels were also detected. RESULTS: Mean serum leptin level and BMI in the NAFLD group were significantly higher than in the con- trols (both P < 0.001), but mean sOB-R level was lower in the NAFLD group when compared to the controls. Both men and women in the NAFLD group had higher mean serum leptin levels and lower sOB-R levels than did the men and women in the control group (all P < 0.001). The- re was a significant negative correlation between serum leptin and sOB-R levels (r = -0.725, P < 0.001). Multiva- riate analysis showed that the percentage of hepatocyte steatosis, sex, BMI, and homeostasis model assessment of insulin resistance (HOMA IR) were independently rela- ted to serum leptin levels. CONCLUSION: Elevated serum leptin seems to be afeature of steatosis, and serum leptin seems to increase as hepatocyte steatosis develops. An enhanced release of leptin is accompanied by an decrease in sOB-R con- centration, which suggests higher resistance of periphe- ral tissues towards the action of leptin.展开更多
Non-thermal atmospheric pressure plasma has emerged as a new promising tool in medicine. The effectiveness of an Atmospheric Non Thermal Plasma for clinical and biological applications is studied. This research effort...Non-thermal atmospheric pressure plasma has emerged as a new promising tool in medicine. The effectiveness of an Atmospheric Non Thermal Plasma for clinical and biological applications is studied. This research effort includes a desioning of plasma generating system and examine it on some medical and biological parameters. No patient had previous operative or chemotherapeutic treatment, so the patients with hematological disorders （hemophilia） and those with open heart surgery that receiving warfarin and other antithrombotic agents were excluded from the study. A total of eighty 80 Iraqi patients seeking for a medical consultation in A1-Ramadi Teaching Hospital were included in this study. The plasma treatment is applied both in vitro and in vivo experiments on those patients. In the in vivo experiments, the bleeding time tests were carried out on these patients; the results showed the bleeding time of the patients was reduced as compared with control. In vitro experiments regarding clotting time and prothrombine time PT, the results have demonstrated that this plasma device clots blood rapidly via a control. The dependencies of the degree of clotting on the exposure time, distance have been recorded. A series of experiments reveal that this effectiveness is due to the ability of direct discharge to bring charges to blood samples due to generation of so many mediators like reactive nitrogen species and free radicals.展开更多
In this paper, a mathematical model for steady blood flow through blood vessels with uniform cross-section in stenoses arteries has been proposed. Blood is assumed to be non- Newtonian, incompressible and homogeneous ...In this paper, a mathematical model for steady blood flow through blood vessels with uniform cross-section in stenoses arteries has been proposed. Blood is assumed to be non- Newtonian, incompressible and homogeneous fluid. Blood in human artery is represented as Bingham plastic fluid. Expressions for flow rate, wall shear stress, and resistance to flow against stenoses size have been obtained. Obtained results indicate that stenoses size decreases the flow rate and increases the wall shear stress as well as resistance to flow.展开更多
文摘AIM: To determine the role of leptin system in non-al- coholic fatty liver disease (NAFLD) development by deli- neating the changes in serum levels of leptin and soluble leptin receptor (sOB-R). METHODS: Blood samples were collected from 30 consecutive patients with liver-biopsy-proven NAFLD and 30 patients with cholecystolithiasis (stationary phase) as controls. Serum leptin levels were determined by radio- immunoassay and concentration of sOB-R was measured by ELISA. Body mass index (BMI) was calculated for all subjects, and serum insulin, C-peptide, and lipoprotein levels were also detected. RESULTS: Mean serum leptin level and BMI in the NAFLD group were significantly higher than in the con- trols (both P < 0.001), but mean sOB-R level was lower in the NAFLD group when compared to the controls. Both men and women in the NAFLD group had higher mean serum leptin levels and lower sOB-R levels than did the men and women in the control group (all P < 0.001). The- re was a significant negative correlation between serum leptin and sOB-R levels (r = -0.725, P < 0.001). Multiva- riate analysis showed that the percentage of hepatocyte steatosis, sex, BMI, and homeostasis model assessment of insulin resistance (HOMA IR) were independently rela- ted to serum leptin levels. CONCLUSION: Elevated serum leptin seems to be afeature of steatosis, and serum leptin seems to increase as hepatocyte steatosis develops. An enhanced release of leptin is accompanied by an decrease in sOB-R con- centration, which suggests higher resistance of periphe- ral tissues towards the action of leptin.
文摘Non-thermal atmospheric pressure plasma has emerged as a new promising tool in medicine. The effectiveness of an Atmospheric Non Thermal Plasma for clinical and biological applications is studied. This research effort includes a desioning of plasma generating system and examine it on some medical and biological parameters. No patient had previous operative or chemotherapeutic treatment, so the patients with hematological disorders （hemophilia） and those with open heart surgery that receiving warfarin and other antithrombotic agents were excluded from the study. A total of eighty 80 Iraqi patients seeking for a medical consultation in A1-Ramadi Teaching Hospital were included in this study. The plasma treatment is applied both in vitro and in vivo experiments on those patients. In the in vivo experiments, the bleeding time tests were carried out on these patients; the results showed the bleeding time of the patients was reduced as compared with control. In vitro experiments regarding clotting time and prothrombine time PT, the results have demonstrated that this plasma device clots blood rapidly via a control. The dependencies of the degree of clotting on the exposure time, distance have been recorded. A series of experiments reveal that this effectiveness is due to the ability of direct discharge to bring charges to blood samples due to generation of so many mediators like reactive nitrogen species and free radicals.
文摘In this paper, a mathematical model for steady blood flow through blood vessels with uniform cross-section in stenoses arteries has been proposed. Blood is assumed to be non- Newtonian, incompressible and homogeneous fluid. Blood in human artery is represented as Bingham plastic fluid. Expressions for flow rate, wall shear stress, and resistance to flow against stenoses size have been obtained. Obtained results indicate that stenoses size decreases the flow rate and increases the wall shear stress as well as resistance to flow.
