医用高分子微针在非透皮局部给药中的研究进展

微针是一种具有广阔发展前景的新型局部给药系统,因具有能够迅速穿透组织屏障、实现局部定点和靶向给药等优点,其应用也逐步扩展到非透皮的给药领域,可以为组织或器官的疾病或损伤提供快速、有效的治疗手段。经过文献检索发现医用高分子微针在非透皮给药的最新应用进展还缺乏归纳和总结,本文首先阐述了相关微针的制备材料及制造技术,接着对微针在非透皮给药领域中的典型应用进行了综述,主要涉及口腔、眼部、血管和心脏等组织或器官疾病的治疗及修复,最后总结现阶段微针在非透皮给药中存在的问题,对其发展进行了展望,以供相关领域的研究者借鉴与参考。

New method of calculating formation parameters of low permeability gas reservoir

The data of modified isochronal testing of gas well is just used to calculate gas well deliverability. Fully utilizing well test data make it possible to obtain formation parameters, such as gas well deliverability, effective permeability and skin factor at the same time. Based on transient flow theory, the pressure drawdown equation of gas unsteady seepage can be deducted. One simulated case is used to illustrate the applicability of the proposed method. The result of analyzed case shows that the proposed method can provide accurate estimate of formation permeability and skin factor compared with the method of Homer curves.