To develop near-infrared （NIR） reflectance spectroscopic methods for the quantitative analysis of cefoperazone sodium/ sulbactam sodium from different manufacturers for injection powder medicaments. Various powders ...To develop near-infrared （NIR） reflectance spectroscopic methods for the quantitative analysis of cefoperazone sodium/ sulbactam sodium from different manufacturers for injection powder medicaments. Various powders of cefoperazone sodium/ sulbactam sodium were directly analyzed by non-destructive NIR reflectance spectroscopy using the spectrometer EQUINOX55. Two quantitative methods via integrating sphere （IS） and fiberoptic probe （FOP） models were explored from 6 batches of commercial samples and 42 batches of laboratory samples at a content ranging from 30% to 70% for cefoperazone and 60% to 20% for sulbactam. The root mean square errors of cross validation （RMSECV） and the root mean square errors of prediction （RMSEP） of IS were 1.79% and 2.85%, respectively, for cefoperazone sodium, and were 1.86% and 3.08%, respectively, for sulbactam sodium; and those of FOP were 2.93% and 2.92%, respectively, for cefoperazone sodium, and were 2.23% and 3.01%, respectively, for sulbactam sodium. Based on the ICH guidelines and Ref. 12, the quantitative models were then evaluated in terms of specificity, linearity, accuracy, precision, robustness and model transferability. The non-destructive quantitative NIR methods used in this study are applicable for rapid analysis of injectable powdered drugs from different manufacturers.展开更多
As one of the key technologies for the fifth generation(5G) wireless networks,device-to-device(D2D) communications allow user equipment(UE) in close proximity to communicate with each other directly.Forwarded by a rel...As one of the key technologies for the fifth generation(5G) wireless networks,device-to-device(D2D) communications allow user equipment(UE) in close proximity to communicate with each other directly.Forwarded by a relay,the relay-aided D2D(RA-D2D) communications can not only be applied to communications in much longer distance but also achieve a high quality of service(Qo S) .In this paper,we first propose a two-layer system model allowing RA-D2 D links to underlay traditional cellular uplinks.Then we maximize the energy efficiency of the RA-D2 D link while satisfying the minimum data-rate of the cellular link.The optimal transmit power at both D2 D transmitter and D2 D relay sides is obtained by transforming the nonlinear fractional programming into a nonlinear parameter programming.Simulation results show that our proposed power allocation method is more energy efficient than the existing works,and the proposed RA-D2 D scheme outperformed direct D2 D scheme when the distance between two D2 D users is longer.展开更多
基金National Key Technologies R&D Program Foundation of China (Grant No. 2006BAK04A11)
文摘To develop near-infrared （NIR） reflectance spectroscopic methods for the quantitative analysis of cefoperazone sodium/ sulbactam sodium from different manufacturers for injection powder medicaments. Various powders of cefoperazone sodium/ sulbactam sodium were directly analyzed by non-destructive NIR reflectance spectroscopy using the spectrometer EQUINOX55. Two quantitative methods via integrating sphere （IS） and fiberoptic probe （FOP） models were explored from 6 batches of commercial samples and 42 batches of laboratory samples at a content ranging from 30% to 70% for cefoperazone and 60% to 20% for sulbactam. The root mean square errors of cross validation （RMSECV） and the root mean square errors of prediction （RMSEP） of IS were 1.79% and 2.85%, respectively, for cefoperazone sodium, and were 1.86% and 3.08%, respectively, for sulbactam sodium; and those of FOP were 2.93% and 2.92%, respectively, for cefoperazone sodium, and were 2.23% and 3.01%, respectively, for sulbactam sodium. Based on the ICH guidelines and Ref. 12, the quantitative models were then evaluated in terms of specificity, linearity, accuracy, precision, robustness and model transferability. The non-destructive quantitative NIR methods used in this study are applicable for rapid analysis of injectable powdered drugs from different manufacturers.
基金supported by the ZTE Corp under Grant CON1412150018the Natural Science Foundation of China under Grant 61572389 and 61471361
文摘As one of the key technologies for the fifth generation(5G) wireless networks,device-to-device(D2D) communications allow user equipment(UE) in close proximity to communicate with each other directly.Forwarded by a relay,the relay-aided D2D(RA-D2D) communications can not only be applied to communications in much longer distance but also achieve a high quality of service(Qo S) .In this paper,we first propose a two-layer system model allowing RA-D2 D links to underlay traditional cellular uplinks.Then we maximize the energy efficiency of the RA-D2 D link while satisfying the minimum data-rate of the cellular link.The optimal transmit power at both D2 D transmitter and D2 D relay sides is obtained by transforming the nonlinear fractional programming into a nonlinear parameter programming.Simulation results show that our proposed power allocation method is more energy efficient than the existing works,and the proposed RA-D2 D scheme outperformed direct D2 D scheme when the distance between two D2 D users is longer.
