AIM： To evaluate the efficacy and tolerability of two different preparations of esomeprazole in healing duodenal ulcers. METHODS： A total of 60 patients with active duodenal ulcers were enrolled and randomized to re...AIM： To evaluate the efficacy and tolerability of two different preparations of esomeprazole in healing duodenal ulcers. METHODS： A total of 60 patients with active duodenal ulcers were enrolled and randomized to receive esomeprazole enteric-coated capsules （40 mg） or esomeprazole magnesium （40 mg）, once daily, for 4 consecutive wk, with ulcer healing being monitored by endoscopy. Safety and tolerability were also assessed. RESULTS： Fifty seven patients completed the whole trial. The ulcer healing rates at the end of wk 2 were 86.7% and 85.2% in the esomeprazole enteric-coated capsules and esomeprazole magnesium groups, respectively （P = 0.8410）, and reached 100% at the end of wk 4 in beth groups. Symptom relief at the end of wk 2 was 90.8% in the esomeprazole enteric-coated capsules group and 86.7% in the esomeprazole magnesium group （P = 0.5406）; at the end of wk 4 symptom relief was 95.2% and 93.2%, respectively （P = 0.5786）. Adverse events occurred in 16.7% of the esomeprazole entericcoated capsules group and 14.8% of the esomeprazole magnesium group （P = 1.0000）. CONCLUSION： The efficacies of esomeprazole entericcoated capsules and esomeprazole magnesium in healing duodenal ulcer lesions and relieving gastrointestinal symptoms are equivalent. The tolerability and safety of beth drugs were comparable.展开更多
Objective： The aim of our study was to compared non-red wax compensator and adding red wax compensator in the treatment plans of the minimum dose, maximum dose, mean dose and target surface dose, and compare the dose...Objective： The aim of our study was to compared non-red wax compensator and adding red wax compensator in the treatment plans of the minimum dose, maximum dose, mean dose and target surface dose, and compare the dose volume histograms （DVH） parameters and isodose distributions of two plans. Methods： From January 2009 to December 2010, 8 patients with superficial head and neck cancer and without surgery treatment were collected. They all confirmed by cancer center, Tianmen First People＇s Hospital. Topslane WiMRT was used to design the treatment plan of non-red wax compensator and adding red wax compensator, with 6 MV photons using three-dimensional conformal irradiation mode design, the prescription dose was 50 Gy/25 times. Results： Compared non-red wax compensator with adding red wax compensator, its target minimum dose （t = -3.157, P 〈 0.05） and the target surface dose sJgnJficantJy improved （t = -0.020, P 〈 0.05）, whJle the target maximum dose （t = -0.140, P 〉 0.05） and mean dose （t = -9.914, P 〉 0.05） were considered no significant difference. Conclusion： The use of U-shaped mask fixed red wax film production in conformal radiotherapy tissue compensator can significantly improve the surface dose and dose distribution superficial planning target volume.展开更多
文摘AIM： To evaluate the efficacy and tolerability of two different preparations of esomeprazole in healing duodenal ulcers. METHODS： A total of 60 patients with active duodenal ulcers were enrolled and randomized to receive esomeprazole enteric-coated capsules （40 mg） or esomeprazole magnesium （40 mg）, once daily, for 4 consecutive wk, with ulcer healing being monitored by endoscopy. Safety and tolerability were also assessed. RESULTS： Fifty seven patients completed the whole trial. The ulcer healing rates at the end of wk 2 were 86.7% and 85.2% in the esomeprazole enteric-coated capsules and esomeprazole magnesium groups, respectively （P = 0.8410）, and reached 100% at the end of wk 4 in beth groups. Symptom relief at the end of wk 2 was 90.8% in the esomeprazole enteric-coated capsules group and 86.7% in the esomeprazole magnesium group （P = 0.5406）; at the end of wk 4 symptom relief was 95.2% and 93.2%, respectively （P = 0.5786）. Adverse events occurred in 16.7% of the esomeprazole entericcoated capsules group and 14.8% of the esomeprazole magnesium group （P = 1.0000）. CONCLUSION： The efficacies of esomeprazole entericcoated capsules and esomeprazole magnesium in healing duodenal ulcer lesions and relieving gastrointestinal symptoms are equivalent. The tolerability and safety of beth drugs were comparable.
文摘Objective： The aim of our study was to compared non-red wax compensator and adding red wax compensator in the treatment plans of the minimum dose, maximum dose, mean dose and target surface dose, and compare the dose volume histograms （DVH） parameters and isodose distributions of two plans. Methods： From January 2009 to December 2010, 8 patients with superficial head and neck cancer and without surgery treatment were collected. They all confirmed by cancer center, Tianmen First People＇s Hospital. Topslane WiMRT was used to design the treatment plan of non-red wax compensator and adding red wax compensator, with 6 MV photons using three-dimensional conformal irradiation mode design, the prescription dose was 50 Gy/25 times. Results： Compared non-red wax compensator with adding red wax compensator, its target minimum dose （t = -3.157, P 〈 0.05） and the target surface dose sJgnJficantJy improved （t = -0.020, P 〈 0.05）, whJle the target maximum dose （t = -0.140, P 〉 0.05） and mean dose （t = -9.914, P 〉 0.05） were considered no significant difference. Conclusion： The use of U-shaped mask fixed red wax film production in conformal radiotherapy tissue compensator can significantly improve the surface dose and dose distribution superficial planning target volume.
