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数字化音乐电胃肠起搏对食管癌术后肠道屏障功能、炎症和氧化应激的影响 被引量:3
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作者 肖玉兰 齐科雷 +2 位作者 王秀娟 李凤茹 吕翠环 《安徽医药》 CAS 2020年第7期1346-1351,共6页
目的探讨数字化音乐电胃肠起搏对食管癌术后肠道屏障功能、炎症和氧化应激的影响。方法选取2016年3月至2018年6月于河北省胸科医院住院的120例食管癌病人作为研究对象,分为四组,即A、B、C和D组,A组病人给予胃肠减压等一般治疗措施,B组... 目的探讨数字化音乐电胃肠起搏对食管癌术后肠道屏障功能、炎症和氧化应激的影响。方法选取2016年3月至2018年6月于河北省胸科医院住院的120例食管癌病人作为研究对象,分为四组,即A、B、C和D组,A组病人给予胃肠减压等一般治疗措施,B组病人在A组的基础上给予足三里穴按摩,C组病人在A组的基础上给予胃肠起搏,D组在A组的基础上给予数字化音乐电胃肠起搏治疗,共治疗7 d。观察胃肠功能的恢复情况,包括肠鸣音恢复时间、排气时间、排便时间、胃管留置时间、胃液引流量;酶联免疫吸附试验检测血清中内毒素、二胺氧化酶(DAO)、紧密连接蛋白(Occludin)、闭锁小带蛋白(ZO-1)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)和白细胞介素-10(IL-10)的含量;蛋白质免疫印迹检测外周血单个核细胞中Toll样受体-4(TLR4)/核因子-κB(NF-κB)信号通路的表达;黄嘌呤氧化酶法检测超氧化物歧化酶(SOD)的活性,硫代巴比妥酸法检测丙二醛(MDA)的含量。结果 D组的肠鸣音恢复时间(36.20±5.15)h、排气时间(52.87±4.51)h、排便时间(73.42±6.92)h、胃管留置时间(80.95±7.65)h、胃液引流量(895.44±101.35)mL、内毒素(5.37±2.40)ng/L、DAO(2.71±0.70)U/L、Occludin(13.61±3.20)μg/L、ZO-1(23.55±3.60)μg/L、TNF-α(12.35±3.61)ng/L、IL-6(16.48±4.01)ng/L、IL-8(37.87±9.71)ng/L均低于A组[(48.72±5.93)h,(68.17±6.45)h,(87.20±6.67)h,(97.34±8.19)h,(1334.50±211.80)mL,(11.83±3.62)ng/L,(3.69±0.53)U/L,(21.56±3.94)μg/L,(31.01±4.33)μg/L,(26.31±4.29)ng/L,(33.72±5.44)ng/L,(82.67±12.55)ng/L]、B组[(45.62±5.50)h,(63.48±6.70)h,(79.95±7.69)h,(91.17±6.89)h,(1180.46±196.15)mL,(8.55±2.19)ng/L,(3.31±0.64)U/L,(19.49±2.88)μg/L,(27.36±4.02)μg/L,(20.70±3.88)ng/L,(25.09±4.85)ng/L,(72.63±11.44)ng/L]、C组[(41.04±6.11)h,(61.25±5.81)h,(77.29±7.13)h,(88.72±9.03)h,(1047.28±160.33)mL,(7.80±3.25)ng/L,(3.12±0.59)U/L,(15.51±3.49)μg/L,(28.11±4.52)μg/L,(17.65±3.24)ng/L,(26.67±5.03)ng/L,(65.51±13.10)ng/L],且B、C组低于A组(P<0.05),但是四组间IL-10的含量差异无统计学意义(P>0.05)。D组外周血单个核细胞中的TLR4(0.44±0.11)和NF-κB(0.28±0.13)蛋白表达量均低于A组[(1.00±0.24),(1.00±0.21)]、B组[(0.86±0.15),(0.84±0.22)]、C组[(0.75±0.20),(0.45±0.16)],且B、C组低于A组(P<0.05)。D组血清中的SOD含量(418.50±36.22)U/L均高于A组(363.62±24.01)U/L、B组(385.09±30.58)U/L、C组(391.33±27.44)U/L,且B、C组高于A组(P<0.05);D组血清中的MDA含量(5.11±0.66)μmol/L均低于A组(6.42±0.85)μmol/L、B组(5.89±0.74)μmol/L、C组(5.65±0.80)μmol/L,且B、C组低于A组(P<0.05)。结论数字化音乐电胃肠起搏能够改善食管癌术后病人的肠道屏障功能,下调血清炎性因子含量和外周血单个核细胞中TLR4/NF-κB信号通路的表达,降低氧化应激水平。 展开更多
关键词 食管肿瘤 音乐疗法/方法 电刺激疗法 穴位疗法 胃肠活动 胃肠起搏 肠道屏障功能 炎症 氧化应激
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Frequently overlooked and rarely listened to: Music therapy in gastrointestinal endoscopic procedures 被引量:4
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作者 Dan Rudin 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第33期4533-4533,共1页
To elucidate the role of music therapy in gastrointestinal endoscopic procedures following the conflicting outcomes reported in two recent studies. The findings of our recent meta-analysis that examined this matter we... To elucidate the role of music therapy in gastrointestinal endoscopic procedures following the conflicting outcomes reported in two recent studies. The findings of our recent meta-analysis that examined this matter were discussed in the context of later studies. Our meta-analysis illustrated the beneficial effects of music therapy on patient anxiety levels when used as a single measure of relaxation and analgesia. Beneficial effects were also shown on analgesia and sedation requirements and procedure duration times when used as an adjunct to pharmacotherapy. These findings are in agreement with those of both studies excluded from analysis and those that followed it. Music therapy is an effective tool for stress relief and analgesia in patients undergoing gastrointestinal endoscopic procedures. 展开更多
关键词 MUSIC ENDOSCOPY COLONOSCOPY Metaanalysis
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Colonoscopy and the role of music therapy: How to go about an ideal protocol? 被引量:3
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作者 R Harikumar Simi Kumar 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第23期3272-3273,共2页
We read with great interest the two articles in the December 2006 issue of your esteemed journal on the utility of music therapy in the performance of colonoscopy. The role of non-pharmacological or cognitive behavior... We read with great interest the two articles in the December 2006 issue of your esteemed journal on the utility of music therapy in the performance of colonoscopy. The role of non-pharmacological or cognitive behavioral interventions in improving performance of GI Endoscopic procedures is actively undergoing research world over. 展开更多
关键词 GASTROENTEROLOGY
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