Objective:The aim of the study was to compare the efficacy,side effect and influence on the survival rate of two chemotherapy regimens,paclitaxel liposome combined with platinum and paclitaxel combined with platinum,i...Objective:The aim of the study was to compare the efficacy,side effect and influence on the survival rate of two chemotherapy regimens,paclitaxel liposome combined with platinum and paclitaxel combined with platinum,in concurrent chemoradiotherapy for cervical carcinoma.Methods:The 162 cases with primary cervical carcinoma diagnosed between January 2008 and November 2009 in Jiangxi Maternal and Child Health Hospital(China) were enrolled in this randomized controlled trial.Seventy-one cases were included in paclitaxel group and 91 in paclitaxel liposome group.And the chemotherapy doses were as follows:paclitaxel liposome and paclitaxel 135 mg/m2;cisplatin 80 mg/m2 or carboplatin AUC 4-6;then repeated every 21 days for two or three times.Radical radiotherapy was given to both groups at the same time.Efficacy was evaluated according to the tumor regression six months later and follow-up was done consistently.Results:The overall response rates of paclitaxel group and paclitaxel liposome group were 90.1% and 89 % respectively(P > 0.05).The one year cumulative survival was 91.4% for paclitaxel group and 89.2% for paclitaxel liposome group(P > 0.05).The incidence rates of adverse effects such as rash,gastrointestinal toxicity,bone marrow suppression and muscle/joint pain in paclitaxel liposome group were much lower than those in paclitaxel group(P < 0.05),while there was no difference regarding hair loss,hepatic function damage,peripheral neuritis and other aspects(P > 0.05).Conclusion:Paclitaxel liposome plus platinum is a safe and effective method for staging IIa-IV cervical carcinomas.While the long-term efficacy should be further observed.展开更多
Based on seismic and drilling data, we calculated tectonic subsidence amounts and rates of the Wan'an Basin by backstripping. The genetic mechanism and syn-rifting process of the basin were analyzed in combination...Based on seismic and drilling data, we calculated tectonic subsidence amounts and rates of the Wan'an Basin by backstripping. The genetic mechanism and syn-rifting process of the basin were analyzed in combination with the regional geological setting. The results reveal that the basin syn-rifted in the Eocene and early Miocene under the control of the dextral strike-slip Wan'an Fault Zone. The transtensional/ extentional stresses along this fault zone may be attributed to seafloor spreading of the South China Sea (SCS) in multiple episodes. Extensive basal faults and some small initial rifts in the early Paleogene can be related to southeastward extrusion and clockwise rotation of the Indochina Block. During the Oligocene, the nearly N-S directed spreading of the SCS derived the transtensional stresses in a roughly NW-SE orientation. The basin subsided rapidly in the middle and north to form two major subsidence centers. In the early Miocene, the SCS spread again in a nearly NW-SE direction, resulting in rapid subsidence in the southern basin continuous extending until the period ～16.3 Ma.展开更多
文摘Objective:The aim of the study was to compare the efficacy,side effect and influence on the survival rate of two chemotherapy regimens,paclitaxel liposome combined with platinum and paclitaxel combined with platinum,in concurrent chemoradiotherapy for cervical carcinoma.Methods:The 162 cases with primary cervical carcinoma diagnosed between January 2008 and November 2009 in Jiangxi Maternal and Child Health Hospital(China) were enrolled in this randomized controlled trial.Seventy-one cases were included in paclitaxel group and 91 in paclitaxel liposome group.And the chemotherapy doses were as follows:paclitaxel liposome and paclitaxel 135 mg/m2;cisplatin 80 mg/m2 or carboplatin AUC 4-6;then repeated every 21 days for two or three times.Radical radiotherapy was given to both groups at the same time.Efficacy was evaluated according to the tumor regression six months later and follow-up was done consistently.Results:The overall response rates of paclitaxel group and paclitaxel liposome group were 90.1% and 89 % respectively(P > 0.05).The one year cumulative survival was 91.4% for paclitaxel group and 89.2% for paclitaxel liposome group(P > 0.05).The incidence rates of adverse effects such as rash,gastrointestinal toxicity,bone marrow suppression and muscle/joint pain in paclitaxel liposome group were much lower than those in paclitaxel group(P < 0.05),while there was no difference regarding hair loss,hepatic function damage,peripheral neuritis and other aspects(P > 0.05).Conclusion:Paclitaxel liposome plus platinum is a safe and effective method for staging IIa-IV cervical carcinomas.While the long-term efficacy should be further observed.
基金Supported by the National Basic Research Program of China (973 Program) (No. 2009CB219406)the National Natural Science Foundation of China (No. 40930845)
文摘Based on seismic and drilling data, we calculated tectonic subsidence amounts and rates of the Wan'an Basin by backstripping. The genetic mechanism and syn-rifting process of the basin were analyzed in combination with the regional geological setting. The results reveal that the basin syn-rifted in the Eocene and early Miocene under the control of the dextral strike-slip Wan'an Fault Zone. The transtensional/ extentional stresses along this fault zone may be attributed to seafloor spreading of the South China Sea (SCS) in multiple episodes. Extensive basal faults and some small initial rifts in the early Paleogene can be related to southeastward extrusion and clockwise rotation of the Indochina Block. During the Oligocene, the nearly N-S directed spreading of the SCS derived the transtensional stresses in a roughly NW-SE orientation. The basin subsided rapidly in the middle and north to form two major subsidence centers. In the early Miocene, the SCS spread again in a nearly NW-SE direction, resulting in rapid subsidence in the southern basin continuous extending until the period ～16.3 Ma.
