AIM:To study the pharmacological profile and inhibition of smooth muscle contraction by YFa and its analogs in conjunction with their receptor selectivity. METHODS:The effects of YFa and its analogs (D-Ala2) YFa, Y (D...AIM:To study the pharmacological profile and inhibition of smooth muscle contraction by YFa and its analogs in conjunction with their receptor selectivity. METHODS:The effects of YFa and its analogs (D-Ala2) YFa, Y (D-Ala2) GFMKKKFMRF amide and Des-Phe-YGGFMKKKFMR amide in guinea pig ileum (GPI) and mouse vas deferens (MVD) motility were studied using an isolated tissue organ bath system, and morphine and DynA (1-13) served as controls. Acetylcholine was used for muscle stimulation. The observations were validated by specific antagonist pretreatment experiments using naloxonazine, naltrindole and norbinaltor-phimine norBNI. RESULTS:YFa did not demonstrate significant inhibition of GPI muscle contraction as compared with mor-phine (15% vs 62%, P = 0.0002), but moderate inhibition of MVD muscle contraction, indicating the role of κ opioid receptors in the contraction. A moderate inhibition of GPI muscles by (Des-Phe) YFa revealed the role of anti-opiate receptors in the smooth muscle contraction. (D-Ala-2) YFa showed significant inhibition of smooth muscle contraction, indicating the involvement of mainly δ receptors in MVD contraction. These results were supported by specific antagonist pretreatment assays. CONCLUSION:YFa revealed its side-effect-free analgesic properties with regard to arrest of gastroin-testinal transit. The study provides evidences for the involvement of κ and anti-opioid receptors in smooth muscle contraction.展开更多
Health care is an area in which all who are involved should try to ensure that the quality of the provision is at a high level, especially in maternity wards. The quality of these services is not only the competence o...Health care is an area in which all who are involved should try to ensure that the quality of the provision is at a high level, especially in maternity wards. The quality of these services is not only the competence of the medical staff, but the whole set of factors prevailing in the ward and in the hospital, from cleanliness of the delivery room to the staff courtesy of the institution. The article presents the results of research on clients＇ satisfaction with the quality of the services offered by the selected maternity ward in Provincial Hospital in Bielsko-Biala. Customer Satisfaction Index （CSI） method was used for analysis.展开更多
Being overweight and obese impacts health due to adiposity itself and illnesses it incurs,which produces individual and societal financial burdens.This urges effective interventions,including adjunct therapies.Acupunc...Being overweight and obese impacts health due to adiposity itself and illnesses it incurs,which produces individual and societal financial burdens.This urges effective interventions,including adjunct therapies.Acupuncture,a traditional Chinese medical practice,indicates positive signs for tackling these problems.Investigating 101 empirical human-based projects,this narrative review analyses their outcomes and then provides an overview of the effects of acupuncture in body weight reduction and obesity-induced diseases,either performed alone or with other approaches.It involves 15941 participants from 9-80 years old in China's Mainland,Taiwan,Turkey,Brazil,Egypt,Iran,Greece,Korea,Sudan,Thailand,and the USA.It also reveals practical implications and future research directions,benefiting the development of acupuncture in the modern medical arena for both patients and practitioners.展开更多
Objective： To make a retrospective control study of the curative effects of ＂Four sacral needles＂ method and conventional acupuncture therapy on female stress incontinence. Methods：A treatment group was treated by...Objective： To make a retrospective control study of the curative effects of ＂Four sacral needles＂ method and conventional acupuncture therapy on female stress incontinence. Methods：A treatment group was treated by ＂Four sacral needles＂ method, in which four sacral points were electroacupunctured with special insertion of needles to excite the pudendal nerve and induce the rhythmic contraction of the pelvic floor muscles, thereby increasing the strength of the pelvic floor muscles and improving ability in urinary continence. A control group was treated by conventional acupuncture therapy, in which corresponding points were acupunctured according to syndrome-based classification. Results： In the 31 cases of the treatment group treated by ＂Four sacral needles＂ method, 100% symptom improvement occurred in 22（71.0% ）after an average of 21 treatments （3-63 treatments）. In the 34 cases of the control group treated by conventional acupuncture therapy, 100% symptom improvement occurred in 0 after 30 treatments. The curative effect was better in the treatment group than in the control group（p〈 0.01）.The curative effect improved with an increase in the number of treatments in the treatment group. Conclusion： ＂Four sacral needles＂ method is more effective than conventional acupuncture therapy in treating female stress incontinence.展开更多
基金Supported by Council of Scientific and Industrial Research,Delhi
文摘AIM:To study the pharmacological profile and inhibition of smooth muscle contraction by YFa and its analogs in conjunction with their receptor selectivity. METHODS:The effects of YFa and its analogs (D-Ala2) YFa, Y (D-Ala2) GFMKKKFMRF amide and Des-Phe-YGGFMKKKFMR amide in guinea pig ileum (GPI) and mouse vas deferens (MVD) motility were studied using an isolated tissue organ bath system, and morphine and DynA (1-13) served as controls. Acetylcholine was used for muscle stimulation. The observations were validated by specific antagonist pretreatment experiments using naloxonazine, naltrindole and norbinaltor-phimine norBNI. RESULTS:YFa did not demonstrate significant inhibition of GPI muscle contraction as compared with mor-phine (15% vs 62%, P = 0.0002), but moderate inhibition of MVD muscle contraction, indicating the role of κ opioid receptors in the contraction. A moderate inhibition of GPI muscles by (Des-Phe) YFa revealed the role of anti-opiate receptors in the smooth muscle contraction. (D-Ala-2) YFa showed significant inhibition of smooth muscle contraction, indicating the involvement of mainly δ receptors in MVD contraction. These results were supported by specific antagonist pretreatment assays. CONCLUSION:YFa revealed its side-effect-free analgesic properties with regard to arrest of gastroin-testinal transit. The study provides evidences for the involvement of κ and anti-opioid receptors in smooth muscle contraction.
文摘Health care is an area in which all who are involved should try to ensure that the quality of the provision is at a high level, especially in maternity wards. The quality of these services is not only the competence of the medical staff, but the whole set of factors prevailing in the ward and in the hospital, from cleanliness of the delivery room to the staff courtesy of the institution. The article presents the results of research on clients＇ satisfaction with the quality of the services offered by the selected maternity ward in Provincial Hospital in Bielsko-Biala. Customer Satisfaction Index （CSI） method was used for analysis.
文摘Being overweight and obese impacts health due to adiposity itself and illnesses it incurs,which produces individual and societal financial burdens.This urges effective interventions,including adjunct therapies.Acupuncture,a traditional Chinese medical practice,indicates positive signs for tackling these problems.Investigating 101 empirical human-based projects,this narrative review analyses their outcomes and then provides an overview of the effects of acupuncture in body weight reduction and obesity-induced diseases,either performed alone or with other approaches.It involves 15941 participants from 9-80 years old in China's Mainland,Taiwan,Turkey,Brazil,Egypt,Iran,Greece,Korea,Sudan,Thailand,and the USA.It also reveals practical implications and future research directions,benefiting the development of acupuncture in the modern medical arena for both patients and practitioners.
文摘Objective： To make a retrospective control study of the curative effects of ＂Four sacral needles＂ method and conventional acupuncture therapy on female stress incontinence. Methods：A treatment group was treated by ＂Four sacral needles＂ method, in which four sacral points were electroacupunctured with special insertion of needles to excite the pudendal nerve and induce the rhythmic contraction of the pelvic floor muscles, thereby increasing the strength of the pelvic floor muscles and improving ability in urinary continence. A control group was treated by conventional acupuncture therapy, in which corresponding points were acupunctured according to syndrome-based classification. Results： In the 31 cases of the treatment group treated by ＂Four sacral needles＂ method, 100% symptom improvement occurred in 22（71.0% ）after an average of 21 treatments （3-63 treatments）. In the 34 cases of the control group treated by conventional acupuncture therapy, 100% symptom improvement occurred in 0 after 30 treatments. The curative effect was better in the treatment group than in the control group（p〈 0.01）.The curative effect improved with an increase in the number of treatments in the treatment group. Conclusion： ＂Four sacral needles＂ method is more effective than conventional acupuncture therapy in treating female stress incontinence.
