Background Primary percutaneous intervention （PPCI） is the treatment of choice for ST elevation myocardial infarction （STEMI） but robust evidence in the very elderly is lacking. We compared PPCI outcomes between d...Background Primary percutaneous intervention （PPCI） is the treatment of choice for ST elevation myocardial infarction （STEMI） but robust evidence in the very elderly is lacking. We compared PPCI outcomes between different age quartiles （quartile I 〈 60 years, quartile 2 〉 60 to 〈 70 years, quartile 3 〉 70 to 〈 80 years, quartile 4 〉 80 years）. Methods Retrospective observational analysis of our Morriston Tertiary Cardiac Center （Abertawe Bro Morgannwg University Health Board） patients from 2005 to 2010 with STEMI who underwent PPCI. Resnlts Of 434 patients, 57 （13%） were in quartile 4 （〉 80 years）. In older age quartiles, patients were less likely to receive a drug eluting stent （DES, P = 0.001） or glycoprotein IlbAIIa inhibitor （GPI, P 〈 0.0001）. Increase in age was associated with reduced time to survival （13-coefficient： -0.192, t： -3,70, 95%CI： --4.91 to -1.50, P 〈 0.0001） as was the presence of cardiogenic shock 03-coefficient： -0.194, t = 3.77, 95%CI： -5.26 to -1.65, P 〈 0.0001）. Use of GPI was associated with increased time to survival （p-coefficient： 0.138, t = 2.82, 95%CI： 1.58-8.58, P = 0.005） but older age quartiles were less likely to receive GPI （P 〈 0.0001）. In-hospital mortality （1.8% quartile 1, 3.6% quartile 2, 10.9% quartile 3 and 12.3% quartile 4, P = 0.002） and 1-year mortality （5.4% quartile 1, 5.5% quartile 2, 16.8% quartile 3 and 24.6% quartile 4, P 〈 0.0001, respectively） was significantly higher in older age quartiles. Conclusions Increased short term and intermediate term mortality is seen in the very elderly after PPCI. Age and cardiogenic shock were prognostic factors. Intervention should not be based on age alone and awareness regarding prognostic factors can help improve management.展开更多
It is very difficult to clearly detect the location of a burning area in a coal mine since it is hidden underground.So we conducted research on the distribution of the burning area before controlling it.Firstly,the or...It is very difficult to clearly detect the location of a burning area in a coal mine since it is hidden underground.So we conducted research on the distribution of the burning area before controlling it.Firstly,the original drilling technique was used to analyze and determine the loose and scope of caving of burning area through field test,and then obtained the gases and the temperature data in this area were according to the borehole data.By analyzing these data,we found out that the location of burning area concentrated in the loose and caving area;and finally,the location and development of the burning area within the tested area were accurately determined.Based on this theory,we used the ground penetrating radar(GPR) to find out the loose and caving scale in the burning area during the control process of the burning area,and then located the fire-extinguishing boreholes within target which we used to control burning fire in the section.A mobile comprehensive fire prevention and extinguishing system based on the three-phase foam fire prevention and control technique was then adopted and conducted in the burning area which took only 9 months to extinguish the 227,000 m 2 of burning area of 9# coal.This control technology and experience will provide a very important reference to the control of other coalfield fire and hillock fire in the future.展开更多
This paper proposes a numerical method for the study of ventilation efficiency in buildings. The developed model is validated with the experimental results of Nielsen who tested the isothermal flow in a scaled model o...This paper proposes a numerical method for the study of ventilation efficiency in buildings. The developed model is validated with the experimental results of Nielsen who tested the isothermal flow in a scaled model of a ventilated room. A zonal method is used to predict airflow patterns in the same ventilated room. The different equations governing the flow in the room were coded in Matlab for different operating conditions, different zonal configurations of the room and different number of cells （control volumes）. The efficiency of the ventilation was determined by calculating the number of ACH （air changes per hour） for each cell. The present results show the importance of the inlet air flow rate, the space resolution and the jet inlet dimensions on the determination of air quality.展开更多
Objective Brachial-ankle pulse wave velocity （baPWV） is widely used as a simple noninvasive measure of arterial softness. The aim of this study was to evaluate the usefulness of baPWV as a predictor of the carotid a...Objective Brachial-ankle pulse wave velocity （baPWV） is widely used as a simple noninvasive measure of arterial softness. The aim of this study was to evaluate the usefulness of baPWV as a predictor of the carotid artery atherosclerosis in the elderly. Methods A total of 721 elderly participants （mean ~ SD age, 70.3 -4- 5.6years） were enrolled in the current study. All participant underwent both baPWV measurement and B-mode ultrasound for the intima-media thickness. Carotid atherosclerosis （CAS） was defined as the present of carotid plaque or and/or intima media thickness for at least 1.1 mm. Results A multivariate logistic regression analysis reveals that age, sex, brachial-ankle pulse wave velocity, smoking and LDL-C level showed a significant correlation with the presence of CAS. The odds ratios of CAS associated with a 500cm/s increase of brachial-ankle pulse wave velocity were 2.378 [95% confidence interval, 1.36 to 4.00, P〈0.05], 3.733 [95% confidence interval, 1.729 to 8.058, P〈0.01], 4.438 [95% confidence interval, 1.659 to 11.803, P〈0.01]. The baPWV significantly correlated with IMT by bivariate correlation analysis （r=-0.39; p=0.001）. After adjusting for factors influencing, baPWV all the same correlated with IMT （r=-0.35; p=0.001）.Conclusion These results indicate that brachial-ankle PWV is an independent predictor of CAS in the elderly.It also means that the direct measurement of arterial stiffness by this simple method may be of great help for the evaluation of carotid artherosclerosis, at least in the elderly展开更多
To realize real-time monitoring and short-term forecasting and forewarning of coalmine ventilation systems(CVS), in this paper, we first established a joint surface and underground CVS safety management system consist...To realize real-time monitoring and short-term forecasting and forewarning of coalmine ventilation systems(CVS), in this paper, we first established a joint surface and underground CVS safety management system consisting of main ventilation fan, safety-partition linked passageways, and air-required locations. We then applied chaos theory to identify the air quantity and gas concentration of underground partition boundaries, and adopted a fixed data quantity, multi-step progressive, weighted first-order local-domain method to setup a chaos prediction model and a CVS safety forecasting and forewarning system formed by the normal change level, orange forewarning level, and red alarm level. We next conduct the on-field application of the system in a coalmine in Jining, Shandong, China. The results showed that (1) in the statistical scale of 5 min, the changes in both air quantity and gas concentration along CVS partition airflow boundaries were characteristic of chaos and could be used for short-term chaos prediction, and the latter was more chaotic than the former;(2) the setup chaos prediction model had a higher prediction precision and the established safety prediction system could not only predict the variation in CVS stability but also reflect the rationality of underground mining intensity. Thus, this CVS safety forecasting and forewarning system is of better application value.展开更多
Using frequency and time domain analysis, the authors analyzed the hydrodynamics and motion behavior of a Truss Spar platform at a water depth of 1500 m in the Liwan 3-1 area of the South China Sea. Firstly, the seake...Using frequency and time domain analysis, the authors analyzed the hydrodynamics and motion behavior of a Truss Spar platform at a water depth of 1500 m in the Liwan 3-1 area of the South China Sea. Firstly, the seakeeping ability is acquired in the frequency domain by calculating the hull's hydrodynamics and comparing with a semi-submersible platform. The random wave analysis for 100-year, 10-year and 1-year return periods in Liwan 3-1 distinctly shows lower heave but larger surge and pitch re-sponses of the Truss Spar than those of a semi-submersible. Secondly, 3-hour motions of the Truss Spar are predicted and compared in the time domain under 100-year return period conditions in Liwan 3-1 and the Gulf of Mexico. Thirdly, the hull/mooring line cou-pled and uncoupled models are compared. Finally, the responses of the Truss Spar under 10-year and 1-year return period conditions are assessed. The results reveal that the mooring line damping reflected by the coupled model distinctly decreases the low frequency motion. The maximum heave response for 100-year return period waves is 1.23m and below 0.1m for the case of 1-year return period.展开更多
Early oceans （〉520 Ma） were characterized by widespread water-column anoxia, stratification, and limited oxidant availability which are comparable to the chemical characteristics of modern marine sedimentary pore-w...Early oceans （〉520 Ma） were characterized by widespread water-column anoxia, stratification, and limited oxidant availability which are comparable to the chemical characteristics of modern marine sedimentary pore-waters in productive continental margins. Based on this similarity and our current understanding of the formation mechanism of early Earth ocean chemistry, we propose an idealized chemical zonation model for early oceans that includes the following redox zones （from shallow nearshore to deep offshore regions）： oxic, nitrogenous （NO3^-NO2^-enriched）, manganous-ferruginous （Mn^2＋ or Fe^2＋-enriched）, sulfidic （H2S-enriched）, methanic （CH4-enriched）, and ferruginous （Fe^2＋-enriched）. These zones were dynamically maintained by a combination of processes including surface-water oxygenation by atmospheric free oxygen, nitrate reduction beneath the chemocline, nearshore manganese-iron reduction, sulfate reduction, methanogenesis, and hydrothennal Fe^2＋ inputs from the deep ocean. Our modified ＂euxinic wedge＂ model expands on previous versions of this model, providing a more complete theoretical framework for the chemical zonation of early Earth oceans that helps to explain observations of unusual Mo-S-C isotope patterns. This model may provide a useful foundation for future studies of ocean chemistry evolution and elemental biogeochemical cycles in early Earth history.展开更多
文摘Background Primary percutaneous intervention （PPCI） is the treatment of choice for ST elevation myocardial infarction （STEMI） but robust evidence in the very elderly is lacking. We compared PPCI outcomes between different age quartiles （quartile I 〈 60 years, quartile 2 〉 60 to 〈 70 years, quartile 3 〉 70 to 〈 80 years, quartile 4 〉 80 years）. Methods Retrospective observational analysis of our Morriston Tertiary Cardiac Center （Abertawe Bro Morgannwg University Health Board） patients from 2005 to 2010 with STEMI who underwent PPCI. Resnlts Of 434 patients, 57 （13%） were in quartile 4 （〉 80 years）. In older age quartiles, patients were less likely to receive a drug eluting stent （DES, P = 0.001） or glycoprotein IlbAIIa inhibitor （GPI, P 〈 0.0001）. Increase in age was associated with reduced time to survival （13-coefficient： -0.192, t： -3,70, 95%CI： --4.91 to -1.50, P 〈 0.0001） as was the presence of cardiogenic shock 03-coefficient： -0.194, t = 3.77, 95%CI： -5.26 to -1.65, P 〈 0.0001）. Use of GPI was associated with increased time to survival （p-coefficient： 0.138, t = 2.82, 95%CI： 1.58-8.58, P = 0.005） but older age quartiles were less likely to receive GPI （P 〈 0.0001）. In-hospital mortality （1.8% quartile 1, 3.6% quartile 2, 10.9% quartile 3 and 12.3% quartile 4, P = 0.002） and 1-year mortality （5.4% quartile 1, 5.5% quartile 2, 16.8% quartile 3 and 24.6% quartile 4, P 〈 0.0001, respectively） was significantly higher in older age quartiles. Conclusions Increased short term and intermediate term mortality is seen in the very elderly after PPCI. Age and cardiogenic shock were prognostic factors. Intervention should not be based on age alone and awareness regarding prognostic factors can help improve management.
基金funded by the National Natural Science Foundation of China (No. 51134020)the State Key Laboratory of Coal Resources and Mine Safety Foundation (No.SKLCRSM08x06)the Natural Science Foundation of Jiangsu Province (No. BK2009004)
文摘It is very difficult to clearly detect the location of a burning area in a coal mine since it is hidden underground.So we conducted research on the distribution of the burning area before controlling it.Firstly,the original drilling technique was used to analyze and determine the loose and scope of caving of burning area through field test,and then obtained the gases and the temperature data in this area were according to the borehole data.By analyzing these data,we found out that the location of burning area concentrated in the loose and caving area;and finally,the location and development of the burning area within the tested area were accurately determined.Based on this theory,we used the ground penetrating radar(GPR) to find out the loose and caving scale in the burning area during the control process of the burning area,and then located the fire-extinguishing boreholes within target which we used to control burning fire in the section.A mobile comprehensive fire prevention and extinguishing system based on the three-phase foam fire prevention and control technique was then adopted and conducted in the burning area which took only 9 months to extinguish the 227,000 m 2 of burning area of 9# coal.This control technology and experience will provide a very important reference to the control of other coalfield fire and hillock fire in the future.
文摘This paper proposes a numerical method for the study of ventilation efficiency in buildings. The developed model is validated with the experimental results of Nielsen who tested the isothermal flow in a scaled model of a ventilated room. A zonal method is used to predict airflow patterns in the same ventilated room. The different equations governing the flow in the room were coded in Matlab for different operating conditions, different zonal configurations of the room and different number of cells （control volumes）. The efficiency of the ventilation was determined by calculating the number of ACH （air changes per hour） for each cell. The present results show the importance of the inlet air flow rate, the space resolution and the jet inlet dimensions on the determination of air quality.
文摘Objective Brachial-ankle pulse wave velocity （baPWV） is widely used as a simple noninvasive measure of arterial softness. The aim of this study was to evaluate the usefulness of baPWV as a predictor of the carotid artery atherosclerosis in the elderly. Methods A total of 721 elderly participants （mean ~ SD age, 70.3 -4- 5.6years） were enrolled in the current study. All participant underwent both baPWV measurement and B-mode ultrasound for the intima-media thickness. Carotid atherosclerosis （CAS） was defined as the present of carotid plaque or and/or intima media thickness for at least 1.1 mm. Results A multivariate logistic regression analysis reveals that age, sex, brachial-ankle pulse wave velocity, smoking and LDL-C level showed a significant correlation with the presence of CAS. The odds ratios of CAS associated with a 500cm/s increase of brachial-ankle pulse wave velocity were 2.378 [95% confidence interval, 1.36 to 4.00, P〈0.05], 3.733 [95% confidence interval, 1.729 to 8.058, P〈0.01], 4.438 [95% confidence interval, 1.659 to 11.803, P〈0.01]. The baPWV significantly correlated with IMT by bivariate correlation analysis （r=-0.39; p=0.001）. After adjusting for factors influencing, baPWV all the same correlated with IMT （r=-0.35; p=0.001）.Conclusion These results indicate that brachial-ankle PWV is an independent predictor of CAS in the elderly.It also means that the direct measurement of arterial stiffness by this simple method may be of great help for the evaluation of carotid artherosclerosis, at least in the elderly
基金supported by the National Natural Science Foundation of China(Nos.51304128 and 51674158)the Natural Science Foundation of Shandong Province(No.ZR2013EEQ015)
文摘To realize real-time monitoring and short-term forecasting and forewarning of coalmine ventilation systems(CVS), in this paper, we first established a joint surface and underground CVS safety management system consisting of main ventilation fan, safety-partition linked passageways, and air-required locations. We then applied chaos theory to identify the air quantity and gas concentration of underground partition boundaries, and adopted a fixed data quantity, multi-step progressive, weighted first-order local-domain method to setup a chaos prediction model and a CVS safety forecasting and forewarning system formed by the normal change level, orange forewarning level, and red alarm level. We next conduct the on-field application of the system in a coalmine in Jining, Shandong, China. The results showed that (1) in the statistical scale of 5 min, the changes in both air quantity and gas concentration along CVS partition airflow boundaries were characteristic of chaos and could be used for short-term chaos prediction, and the latter was more chaotic than the former;(2) the setup chaos prediction model had a higher prediction precision and the established safety prediction system could not only predict the variation in CVS stability but also reflect the rationality of underground mining intensity. Thus, this CVS safety forecasting and forewarning system is of better application value.
基金the supports from National Sci-Tech Major Special Item (No. 2008ZX05056-03)
文摘Using frequency and time domain analysis, the authors analyzed the hydrodynamics and motion behavior of a Truss Spar platform at a water depth of 1500 m in the Liwan 3-1 area of the South China Sea. Firstly, the seakeeping ability is acquired in the frequency domain by calculating the hull's hydrodynamics and comparing with a semi-submersible platform. The random wave analysis for 100-year, 10-year and 1-year return periods in Liwan 3-1 distinctly shows lower heave but larger surge and pitch re-sponses of the Truss Spar than those of a semi-submersible. Secondly, 3-hour motions of the Truss Spar are predicted and compared in the time domain under 100-year return period conditions in Liwan 3-1 and the Gulf of Mexico. Thirdly, the hull/mooring line cou-pled and uncoupled models are compared. Finally, the responses of the Truss Spar under 10-year and 1-year return period conditions are assessed. The results reveal that the mooring line damping reflected by the coupled model distinctly decreases the low frequency motion. The maximum heave response for 100-year return period waves is 1.23m and below 0.1m for the case of 1-year return period.
基金supported by the National Basic Research Program of China(Grant No.2013CB955704)National Natural Science Foundation of China(Grant No.41172030)support from the U.S.National Science Foundation,the NASA Exobiology Program,and the China University of Geosciences(Wuhan)(SKL-GPMR program GPMR201301,and SKL-BGEG program BGL21407)
文摘Early oceans （〉520 Ma） were characterized by widespread water-column anoxia, stratification, and limited oxidant availability which are comparable to the chemical characteristics of modern marine sedimentary pore-waters in productive continental margins. Based on this similarity and our current understanding of the formation mechanism of early Earth ocean chemistry, we propose an idealized chemical zonation model for early oceans that includes the following redox zones （from shallow nearshore to deep offshore regions）： oxic, nitrogenous （NO3^-NO2^-enriched）, manganous-ferruginous （Mn^2＋ or Fe^2＋-enriched）, sulfidic （H2S-enriched）, methanic （CH4-enriched）, and ferruginous （Fe^2＋-enriched）. These zones were dynamically maintained by a combination of processes including surface-water oxygenation by atmospheric free oxygen, nitrate reduction beneath the chemocline, nearshore manganese-iron reduction, sulfate reduction, methanogenesis, and hydrothennal Fe^2＋ inputs from the deep ocean. Our modified ＂euxinic wedge＂ model expands on previous versions of this model, providing a more complete theoretical framework for the chemical zonation of early Earth oceans that helps to explain observations of unusual Mo-S-C isotope patterns. This model may provide a useful foundation for future studies of ocean chemistry evolution and elemental biogeochemical cycles in early Earth history.
