Objective： The aim of the study is to investigate the longterm oncologic outcomes including local recurrence, distant metastases and overall survival （OS） for patients with low rectal cancer underwent low anterior ...Objective： The aim of the study is to investigate the longterm oncologic outcomes including local recurrence, distant metastases and overall survival （OS） for patients with low rectal cancer underwent low anterior resection （LAR） with total mesorectal excision （TME）, and to analyze the prognostic factors for them. Methods： Between January 2001 and December 2009, 147 patients with clinical stage II and III rectal cancers located 3-6 cm from the anal verge underwent LAR with TME without temporary diverting stoma. The median distal resection margin （DRM） was 1.0 （range, 0.3-5） cm. Anastomostic leakage occurred in 29 （19.7%） patients. Thirty patients received surgery alone, 20 patients received preoperative chemoradiotherapy （CRT）, 43 patients received postoperative CRT, and adjuvant chemotherapy was administered for 108 patients. The median cycle of adjuvant chemotherapy was 6 （range, 2-20） cycles. The median followup was 74.8 （range, 30.1-146.3） months. Results： In all patients, 5-year recurrence-free survival （RFS）, disease-free survival （DFS） and OS were 70.4%, 54.2% and 60.5%, respectively. Forty-three （29.3%） patients suffered local recurrence. Patients received preoperative CRT with a downstaging yp0/1 who had a better 5-year RFS, DFS and OS, which were 100%, 90.9%, and 90.9%, respectively. For patients with pathologic stage Ⅱ and stage Ⅲ, the 5-year RFS, DFS, and OS were 79.2% and 60.1%, 67.9% and 39.1%, 72.1% and 48.2%, respectively. On multivariable analysis, RFS was associated with anostomostic leakage, DFS was associated with anastomostic leakage and pathologic N stage, and OS was associated with anastomostic leakage, pathologic N and T stage. For patients with anastomostic leakage, the 5-year RFS, DFS, and OS were 51.7%, 32.4%, and 38.3%, respectively, which were worse than that for patients without anastomostic leakage, the latter were 75.2%, 59.7%, 65.7%, respectively （P 〈 0.05）. DRM and radiotherapy were associated with RFS on univariable analysis （P 〈 0.05）, but not on multivariable analysis. Tumor grade was prognostic factors for RFS and OS on univariable analysis, but not on multivariable analysis. The other factors including sex, age, tumor size and adjuvant chemotherapy were not associated with RFS, DFS and OS on univariable analysis. Conclusion： For patients with low rectal caner underwent LAR and TME, the long-term oncologic outcomes were satisfactory for patients with stage yp0/1, but not for patients with pathologic stage II1. Anastomositic leakage negatively affect long-term oncologic outcomes. Radiotherpy, adjuvant chemotherapy and distal resection margin were not associated with long-term outcomes.展开更多
Batch processes are usually involved with multiple phases in the time domain and many researches on process monitoring as well as quality prediction have been done using phase information. However, few of them conside...Batch processes are usually involved with multiple phases in the time domain and many researches on process monitoring as well as quality prediction have been done using phase information. However, few of them consider phase transitions, though they exit widely in batch processes and have non-ignorable impacts on product qualities. In the present work, a phase-based partial least squares (PLS) method utilizing transition information is proposed to give both online and offline quality predictions. First, batch processes are divided into several phases using regression parameters other than prior process knowledge. Then both steady phases and transitions which have great influences on qualities are identified as critical-to-quality phases using statistical methods. Finally, based on the analysis of different characteristics of transitions and steady phases, an integrated algorithm is developed for quality prediction. The application to an injection molding process shows the effectiveness of the proposed algorithm in comparison with the traditional MPLS method and the phase-based PLS method.展开更多
Experiments were conducted in an indoor soil bin filled with sandy clay loam soil. Tests were carried out with tillage tines to study the effect tool width on soil disturbance and draught. Depth of operation was held ...Experiments were conducted in an indoor soil bin filled with sandy clay loam soil. Tests were carried out with tillage tines to study the effect tool width on soil disturbance and draught. Depth of operation was held constant at 35 mm and then at 70 mm while speed was varied at three levels of 1.0, 3.6 and 9.0 km/h. The widths of the tines tested were 10, 20, 31, 40, 51, 88, 126, 163 and 200 mm. The cone penetration resistance of the soil varied from 400 to 600 kPa. Draught was measured with a load cell while soil disturbance was measured with a profile meter and meter rule. Draught increased at a decreasing rate with tine width. Quadratic models best fitted the data points with high R2 values. The increase in draught was affected by the forward speed since higher draught values were obtained at higher speed. Results show that the parameters of soil disturbance increased with increase in tine width, except height of ridge （hr）, which did not show any specific trend. The specific draught was highest （10.63 N/cm） with tine T20 while Tine T1 had the least specific draught of 5.2 N/cm.展开更多
The creep anisotropy behavior under different stresses at 180℃ of hot-extruded AZ91−2Y magnesium alloy with pre-compression(PC)and without pre-compression(NPC)was studied.Microstructure,texture and mechanical propert...The creep anisotropy behavior under different stresses at 180℃ of hot-extruded AZ91−2Y magnesium alloy with pre-compression(PC)and without pre-compression(NPC)was studied.Microstructure,texture and mechanical properties of the alloy were examined by scanning electron microscopy(SEM),electron backscatter diffraction(EBSD),transmission electron microscopy(TEM)and tensile creep tests.The results revealed that the creep resistance was proportional to the volume fraction of spherical Mg_(17)Al_(12) precipitates.The dynamic precipitation of large volume fraction of lamellar Mg_(17)Al_(12) in NPC samples leads to the basaláañslip as the dominant creep mechanism,and the NPC samples have obvious anisotropy.In the PC samples,dynamic precipitation of large volume fraction of spherical Mg_(17)Al_(12) has inhibitory effect on the basaláañslip.The pyramidalác+añslip and twinning improve the creep anisotropy resistance significantly.展开更多
Using a diffusion model we investigate deformation effects on the sensitivity of different light particles to nuclear dissipation for a rather neutron-deficlent ^178Pb system. Galculations show that deformation signif...Using a diffusion model we investigate deformation effects on the sensitivity of different light particles to nuclear dissipation for a rather neutron-deficlent ^178Pb system. Galculations show that deformation significantly increases the sensitivity of neutron emission to dissipation strength, and that this effect becomes stronger with increasing deformation.展开更多
To study the deformability and ductility of an innovative precast shear wall joined by bolted connections,experimental tests were conducted on two test walls under monotonic and cyclic loading,respectively;subsequentl...To study the deformability and ductility of an innovative precast shear wall joined by bolted connections,experimental tests were conducted on two test walls under monotonic and cyclic loading,respectively;subsequently,theoretical analysis was performed on the deformation performance of the shear wall assembly.The test results confirmed the favorable deformability and ductility of the specimens.The top displacement of the shear wall assembly was analytically decomposed into several constituent parts,the theoretical formulae of which were subsequently deduced.The compositional analysis demonstrated that the top displacement of the test wall was primarily induced by the elastic deformation of the upper wall panel(UWP),the relative slippages within the bolted connections,and the flexural deformation within the plastic region of the UWP,while the constituent part contributed by the deformation in the connecting steel frame can be neglected.展开更多
文摘Objective： The aim of the study is to investigate the longterm oncologic outcomes including local recurrence, distant metastases and overall survival （OS） for patients with low rectal cancer underwent low anterior resection （LAR） with total mesorectal excision （TME）, and to analyze the prognostic factors for them. Methods： Between January 2001 and December 2009, 147 patients with clinical stage II and III rectal cancers located 3-6 cm from the anal verge underwent LAR with TME without temporary diverting stoma. The median distal resection margin （DRM） was 1.0 （range, 0.3-5） cm. Anastomostic leakage occurred in 29 （19.7%） patients. Thirty patients received surgery alone, 20 patients received preoperative chemoradiotherapy （CRT）, 43 patients received postoperative CRT, and adjuvant chemotherapy was administered for 108 patients. The median cycle of adjuvant chemotherapy was 6 （range, 2-20） cycles. The median followup was 74.8 （range, 30.1-146.3） months. Results： In all patients, 5-year recurrence-free survival （RFS）, disease-free survival （DFS） and OS were 70.4%, 54.2% and 60.5%, respectively. Forty-three （29.3%） patients suffered local recurrence. Patients received preoperative CRT with a downstaging yp0/1 who had a better 5-year RFS, DFS and OS, which were 100%, 90.9%, and 90.9%, respectively. For patients with pathologic stage Ⅱ and stage Ⅲ, the 5-year RFS, DFS, and OS were 79.2% and 60.1%, 67.9% and 39.1%, 72.1% and 48.2%, respectively. On multivariable analysis, RFS was associated with anostomostic leakage, DFS was associated with anastomostic leakage and pathologic N stage, and OS was associated with anastomostic leakage, pathologic N and T stage. For patients with anastomostic leakage, the 5-year RFS, DFS, and OS were 51.7%, 32.4%, and 38.3%, respectively, which were worse than that for patients without anastomostic leakage, the latter were 75.2%, 59.7%, 65.7%, respectively （P 〈 0.05）. DRM and radiotherapy were associated with RFS on univariable analysis （P 〈 0.05）, but not on multivariable analysis. Tumor grade was prognostic factors for RFS and OS on univariable analysis, but not on multivariable analysis. The other factors including sex, age, tumor size and adjuvant chemotherapy were not associated with RFS, DFS and OS on univariable analysis. Conclusion： For patients with low rectal caner underwent LAR and TME, the long-term oncologic outcomes were satisfactory for patients with stage yp0/1, but not for patients with pathologic stage II1. Anastomositic leakage negatively affect long-term oncologic outcomes. Radiotherpy, adjuvant chemotherapy and distal resection margin were not associated with long-term outcomes.
基金Supported by Guangzhou Nansha District Bureau of Economy & Trade, Science & Technology, Information, Project (201103003)the Fundamental Research Funds for the Central Universities (2012QNA5012)+1 种基金Project of Education Department of Zhejiang Province (Y201223159)Technology Foundation for Selected Overseas Chinese Scholar of Zhejiang Province (J20120561)
文摘Batch processes are usually involved with multiple phases in the time domain and many researches on process monitoring as well as quality prediction have been done using phase information. However, few of them consider phase transitions, though they exit widely in batch processes and have non-ignorable impacts on product qualities. In the present work, a phase-based partial least squares (PLS) method utilizing transition information is proposed to give both online and offline quality predictions. First, batch processes are divided into several phases using regression parameters other than prior process knowledge. Then both steady phases and transitions which have great influences on qualities are identified as critical-to-quality phases using statistical methods. Finally, based on the analysis of different characteristics of transitions and steady phases, an integrated algorithm is developed for quality prediction. The application to an injection molding process shows the effectiveness of the proposed algorithm in comparison with the traditional MPLS method and the phase-based PLS method.
文摘Experiments were conducted in an indoor soil bin filled with sandy clay loam soil. Tests were carried out with tillage tines to study the effect tool width on soil disturbance and draught. Depth of operation was held constant at 35 mm and then at 70 mm while speed was varied at three levels of 1.0, 3.6 and 9.0 km/h. The widths of the tines tested were 10, 20, 31, 40, 51, 88, 126, 163 and 200 mm. The cone penetration resistance of the soil varied from 400 to 600 kPa. Draught was measured with a load cell while soil disturbance was measured with a profile meter and meter rule. Draught increased at a decreasing rate with tine width. Quadratic models best fitted the data points with high R2 values. The increase in draught was affected by the forward speed since higher draught values were obtained at higher speed. Results show that the parameters of soil disturbance increased with increase in tine width, except height of ridge （hr）, which did not show any specific trend. The specific draught was highest （10.63 N/cm） with tine T20 while Tine T1 had the least specific draught of 5.2 N/cm.
基金the National Natural Science Foundation of China(Nos.52075048,52171099 and 52105140)the Natural Science Foundation of Hunan Province,China(No.2021JJ40583)+2 种基金the Science and Technology Innovation Project of Hunan Province,China(No.2018RS3073)the Scientific Research Innovation Project for Graduate Student of Changsha University of Science&Technology,China(No.CX2021SS55)the Double First-class Scientific Research International Cooperation Project of Changsha University of Science and Technology,China(No.2019IC15).
文摘The creep anisotropy behavior under different stresses at 180℃ of hot-extruded AZ91−2Y magnesium alloy with pre-compression(PC)and without pre-compression(NPC)was studied.Microstructure,texture and mechanical properties of the alloy were examined by scanning electron microscopy(SEM),electron backscatter diffraction(EBSD),transmission electron microscopy(TEM)and tensile creep tests.The results revealed that the creep resistance was proportional to the volume fraction of spherical Mg_(17)Al_(12) precipitates.The dynamic precipitation of large volume fraction of lamellar Mg_(17)Al_(12) in NPC samples leads to the basaláañslip as the dominant creep mechanism,and the NPC samples have obvious anisotropy.In the PC samples,dynamic precipitation of large volume fraction of spherical Mg_(17)Al_(12) has inhibitory effect on the basaláañslip.The pyramidalác+añslip and twinning improve the creep anisotropy resistance significantly.
基金The project supported by National Natural Science Foundation of China under Grant No. 10405007 and the Teaching and Researching Foundation of the Excellent Teacher of Southeast University
文摘Using a diffusion model we investigate deformation effects on the sensitivity of different light particles to nuclear dissipation for a rather neutron-deficlent ^178Pb system. Galculations show that deformation significantly increases the sensitivity of neutron emission to dissipation strength, and that this effect becomes stronger with increasing deformation.
基金supported by the National Natural Science Foundation of China(Grant No.51078077)
文摘To study the deformability and ductility of an innovative precast shear wall joined by bolted connections,experimental tests were conducted on two test walls under monotonic and cyclic loading,respectively;subsequently,theoretical analysis was performed on the deformation performance of the shear wall assembly.The test results confirmed the favorable deformability and ductility of the specimens.The top displacement of the shear wall assembly was analytically decomposed into several constituent parts,the theoretical formulae of which were subsequently deduced.The compositional analysis demonstrated that the top displacement of the test wall was primarily induced by the elastic deformation of the upper wall panel(UWP),the relative slippages within the bolted connections,and the flexural deformation within the plastic region of the UWP,while the constituent part contributed by the deformation in the connecting steel frame can be neglected.
