Objective: The purpose of this study was to evaluate the outcome of patients with cervical adenocarcinoma and to determine the characteristics and the prognostic factors of this entity. Study design: This retrospectiv...Objective: The purpose of this study was to evaluate the outcome of patients with cervical adenocarcinoma and to determine the characteristics and the prognostic factors of this entity. Study design: This retrospective study was done in the Department of Surgical Oncology of the Salah Azaiz Institute of Tunis with 79 cases of invasive adenocarcinoma of the uterine cervix that were collected from 1990 to 1999. Survival was analyzed according to the Kaplan-Meier method. Univariate analysis of prognostic factors was performed with the test of log rank. Cox regression model was used in multivariate analysis of prognostic factors. Results: Mean age was 50 years, and metrorrhagia was mostly revealing in 73%of the cases. Early stages (I, IIa, IIb with 1/3 proximal parametrial invasion) and “pure”type adenocarcinoma were found in 78%and 87%of the cases, respectively. Treatment consisted of a radiosurgical combination in 52 cases; exclusive radiotherapy was practiced with 17 patients. The 5 year-overall and disease-free survival percentages were, respectively, 68%and 72.4%. Poor prognostic factors were age > 50 years, tumor size > 4 cm, advanced stage, tumor grade, and lymph nodes and lymph-vascular space involvement. With the use of multivariate analysis, only stage and lymph node metastases remained significant prognostic factors. Conclusion: This report shows survival and prognostic factors that are similar to those found in previous studies, but unlike the Western countries, our results demonstrate a high rate of early stages and no increase in frequency of cervical adenocarcinoma.展开更多
阑尾原发性肿瘤非常罕见,组织学多样,阑尾上皮来源肿瘤组织学分为三类,包括黏液腺癌、肠腺癌和印戒细胞腺癌[1]。阑尾黏液腺癌(mucinous adenocarcinomas of appendix,MAA)更为罕见,占所有胃肠道肿瘤的不到0.5%[2],发病中位年龄为60岁,...阑尾原发性肿瘤非常罕见,组织学多样,阑尾上皮来源肿瘤组织学分为三类,包括黏液腺癌、肠腺癌和印戒细胞腺癌[1]。阑尾黏液腺癌(mucinous adenocarcinomas of appendix,MAA)更为罕见,占所有胃肠道肿瘤的不到0.5%[2],发病中位年龄为60岁,迄今尚未发现性别差异[3]。MAA患者无特异性临床表现,因此发现通常较晚,大多数病例是在阑尾手术后确诊或影像学检查中发现。MAA可引起腹膜广泛转移,腹膜转移是不良预后因素。MAA伴腹膜转移的治疗方式包括减瘤手术、腹腔热灌注化疗(HIPEC)和化疗,化疗一般适用于复发转移的患者。本文回顾性分析1例MAA伴腹膜广泛转移患者的临床资料。展开更多
文摘Objective: The purpose of this study was to evaluate the outcome of patients with cervical adenocarcinoma and to determine the characteristics and the prognostic factors of this entity. Study design: This retrospective study was done in the Department of Surgical Oncology of the Salah Azaiz Institute of Tunis with 79 cases of invasive adenocarcinoma of the uterine cervix that were collected from 1990 to 1999. Survival was analyzed according to the Kaplan-Meier method. Univariate analysis of prognostic factors was performed with the test of log rank. Cox regression model was used in multivariate analysis of prognostic factors. Results: Mean age was 50 years, and metrorrhagia was mostly revealing in 73%of the cases. Early stages (I, IIa, IIb with 1/3 proximal parametrial invasion) and “pure”type adenocarcinoma were found in 78%and 87%of the cases, respectively. Treatment consisted of a radiosurgical combination in 52 cases; exclusive radiotherapy was practiced with 17 patients. The 5 year-overall and disease-free survival percentages were, respectively, 68%and 72.4%. Poor prognostic factors were age > 50 years, tumor size > 4 cm, advanced stage, tumor grade, and lymph nodes and lymph-vascular space involvement. With the use of multivariate analysis, only stage and lymph node metastases remained significant prognostic factors. Conclusion: This report shows survival and prognostic factors that are similar to those found in previous studies, but unlike the Western countries, our results demonstrate a high rate of early stages and no increase in frequency of cervical adenocarcinoma.
文摘阑尾原发性肿瘤非常罕见,组织学多样,阑尾上皮来源肿瘤组织学分为三类,包括黏液腺癌、肠腺癌和印戒细胞腺癌[1]。阑尾黏液腺癌(mucinous adenocarcinomas of appendix,MAA)更为罕见,占所有胃肠道肿瘤的不到0.5%[2],发病中位年龄为60岁,迄今尚未发现性别差异[3]。MAA患者无特异性临床表现,因此发现通常较晚,大多数病例是在阑尾手术后确诊或影像学检查中发现。MAA可引起腹膜广泛转移,腹膜转移是不良预后因素。MAA伴腹膜转移的治疗方式包括减瘤手术、腹腔热灌注化疗(HIPEC)和化疗,化疗一般适用于复发转移的患者。本文回顾性分析1例MAA伴腹膜广泛转移患者的临床资料。
