Background Many epidemiological studies analyze the relationship between hyperuricemia and cardiovascular outcomes. This observational prospective study investigates the association of serum uric acid （SUA） levels w...Background Many epidemiological studies analyze the relationship between hyperuricemia and cardiovascular outcomes. This observational prospective study investigates the association of serum uric acid （SUA） levels with adverse cardiovascular events and deaths in an elderly population affected by advanced atherosclerosis. Methods Two hundred and seventy six elderly patients affected by advanced atherosclerosis （217 males and 59 females; aged 71.2 ±7.8 years） were included. All patients were assessed for history of cardiovascular disease, cancer, obesity and traditional risk factors. Patients were followed for approximately 31 ±11 months. Major events were recorded during follow-up, defined as myocardial infarction, cerebral isehemia, myocardial and/or peripheral revascularization and death. Results Mean SUA level was 5.47 ±1.43 mg/dL; then we further divided the population in two groups, according to the median value （5.36 mg/dL）. During a median follow up of 31 months （5 to 49 months）, 66 cardiovascular events, 9 fatal cardiovascular events and 14 cancer-related deaths have occurred. The patients with increased SUA level presented a higher significant incidence of total cardiovascular events （HR： 1.867, P = 0.014, 95% CI： 1.134-3.074）, The same patients showed a significant increased risk of cancer-related death （HR： 4.335, P = 0.025, 95% CI： 1.204-15.606）. Conclusions Increased SUA levels are independently and significantly associated with risk of cardiovascular events and cancer related death in a population of mainly elderly patients affected by peripheral vasculopathy.展开更多
临床研究过程中发生的不良事件的伦理审查一直是难点,文中参考了美国人类研究保护办公室2007年发布的"Guidanceon Reviewing and Reporting Unanticipated Problems Involving Risks to Subjects or Others and Adverse Events&quo...临床研究过程中发生的不良事件的伦理审查一直是难点,文中参考了美国人类研究保护办公室2007年发布的"Guidanceon Reviewing and Reporting Unanticipated Problems Involving Risks to Subjects or Others and Adverse Events",提出对不良事件的伦理审查应侧重关注"非预期事件"。同时,对内部不良事件和外部不良事件区别对待处理。展开更多
European Centre for Medium-Range Weather Forecasts Re-Analysis Interim(ERA-Interim)reanalysis data and satellite data,and trajectory model were applied to analyze the dynamical,thermo-dynamical,and chemical structure ...European Centre for Medium-Range Weather Forecasts Re-Analysis Interim(ERA-Interim)reanalysis data and satellite data,and trajectory model were applied to analyze the dynamical,thermo-dynamical,and chemical structure in the upper troposphere and lower stratosphere(UTLS)of an intense cut-off low(COL)event occurring over East Asia during June 19-23,2010,and to characterize the process and transport pathway of deep stratospheric intrusion.The Atmospheric Infrared Sounder(AIRS)ozone data and the Global Positioning System Ozone(GPSO3)sonde data showed that the air mass originating from the polar formed a region with relatively high values of potential vorticity(PV)and ozone in the center of COL,and a secondary ozone peak appeared in the upper troposphere during mature stage of the COL.Forward trajectory simulation suggested that during the first stage of COL,deep stratospheric intrusion associated with strong northerly wind jet on the west side of the upper-level trough transported ozone-rich air from the polar lower stratosphere into the middle and lower troposphere in the mid-latitude,and increased the ozone concentration there.During the mature stage of the COL,stratospheric air was transported counterclockwise into the troposphere.Backward trajectory model was used to find the source regions of air mass within the COL during its mature stage.Model results show that air masses with high ozone concentration in the center of the COL have two source regions:one is the subpolar vortex which lies in northern part of Center Siberia,where ozone-rich air plays a major role in increasing the ozone concentrations,and the other is the strong shear region which is near by the cyclonic side of the extratropical jet axis(west of 90°E,near 50°N).The air masses with low ozone concentration around the COL also have two source regions:one is the anticyclonic side of the extratropical jet axis,where the air mass with the relatively low ozone concentration at the bottom of the COL is mainly controlled by horizontal movement,and the other is the warm area of the south side of COL,where the air mass on the east and west side of the COL is mainly dominated by upward motion.展开更多
文摘Background Many epidemiological studies analyze the relationship between hyperuricemia and cardiovascular outcomes. This observational prospective study investigates the association of serum uric acid （SUA） levels with adverse cardiovascular events and deaths in an elderly population affected by advanced atherosclerosis. Methods Two hundred and seventy six elderly patients affected by advanced atherosclerosis （217 males and 59 females; aged 71.2 ±7.8 years） were included. All patients were assessed for history of cardiovascular disease, cancer, obesity and traditional risk factors. Patients were followed for approximately 31 ±11 months. Major events were recorded during follow-up, defined as myocardial infarction, cerebral isehemia, myocardial and/or peripheral revascularization and death. Results Mean SUA level was 5.47 ±1.43 mg/dL; then we further divided the population in two groups, according to the median value （5.36 mg/dL）. During a median follow up of 31 months （5 to 49 months）, 66 cardiovascular events, 9 fatal cardiovascular events and 14 cancer-related deaths have occurred. The patients with increased SUA level presented a higher significant incidence of total cardiovascular events （HR： 1.867, P = 0.014, 95% CI： 1.134-3.074）, The same patients showed a significant increased risk of cancer-related death （HR： 4.335, P = 0.025, 95% CI： 1.204-15.606）. Conclusions Increased SUA levels are independently and significantly associated with risk of cardiovascular events and cancer related death in a population of mainly elderly patients affected by peripheral vasculopathy.
文摘临床研究过程中发生的不良事件的伦理审查一直是难点,文中参考了美国人类研究保护办公室2007年发布的"Guidanceon Reviewing and Reporting Unanticipated Problems Involving Risks to Subjects or Others and Adverse Events",提出对不良事件的伦理审查应侧重关注"非预期事件"。同时,对内部不良事件和外部不良事件区别对待处理。
基金supported by the National Basic Research Program of China(Grant No.2010CB428602)the National Natural Science Foundation of China(Grant No.41175040)
文摘European Centre for Medium-Range Weather Forecasts Re-Analysis Interim(ERA-Interim)reanalysis data and satellite data,and trajectory model were applied to analyze the dynamical,thermo-dynamical,and chemical structure in the upper troposphere and lower stratosphere(UTLS)of an intense cut-off low(COL)event occurring over East Asia during June 19-23,2010,and to characterize the process and transport pathway of deep stratospheric intrusion.The Atmospheric Infrared Sounder(AIRS)ozone data and the Global Positioning System Ozone(GPSO3)sonde data showed that the air mass originating from the polar formed a region with relatively high values of potential vorticity(PV)and ozone in the center of COL,and a secondary ozone peak appeared in the upper troposphere during mature stage of the COL.Forward trajectory simulation suggested that during the first stage of COL,deep stratospheric intrusion associated with strong northerly wind jet on the west side of the upper-level trough transported ozone-rich air from the polar lower stratosphere into the middle and lower troposphere in the mid-latitude,and increased the ozone concentration there.During the mature stage of the COL,stratospheric air was transported counterclockwise into the troposphere.Backward trajectory model was used to find the source regions of air mass within the COL during its mature stage.Model results show that air masses with high ozone concentration in the center of the COL have two source regions:one is the subpolar vortex which lies in northern part of Center Siberia,where ozone-rich air plays a major role in increasing the ozone concentrations,and the other is the strong shear region which is near by the cyclonic side of the extratropical jet axis(west of 90°E,near 50°N).The air masses with low ozone concentration around the COL also have two source regions:one is the anticyclonic side of the extratropical jet axis,where the air mass with the relatively low ozone concentration at the bottom of the COL is mainly controlled by horizontal movement,and the other is the warm area of the south side of COL,where the air mass on the east and west side of the COL is mainly dominated by upward motion.
