近年来,健康体检越来越受到人们的重视。优序预检法（optimal order advance check method,OOACM）[1]是由我院经过近3年在健康检查工作中通过不断研究总结,形成的健康科学的管理方法,该法结合现代医学和现代管理学的理论、技术、方法...近年来,健康体检越来越受到人们的重视。优序预检法（optimal order advance check method,OOACM）[1]是由我院经过近3年在健康检查工作中通过不断研究总结,形成的健康科学的管理方法,该法结合现代医学和现代管理学的理论、技术、方法和手段,能够实现对个体或群体健康状况及其影响健康的危险因素进行全面检测、评估、有效干预与连续跟踪服务的医学行为及过程。展开更多
Petroleum geophysicists recognize that many parameters related to oil and gas reservoirs are predicted using seismic attribute data. However, how best to optimize the seismic attributes, predict the character of thin ...Petroleum geophysicists recognize that many parameters related to oil and gas reservoirs are predicted using seismic attribute data. However, how best to optimize the seismic attributes, predict the character of thin sandstone reservoirs, and enhance the reservoir description accuracy is an important goal for geologists and geophysicists. Based on the theory of main component analysis, we present a new optimization method, called constrained main component analysis. Modeling estimates and real application in an oilfield show that it can enhance reservoir prediction accuracy and has better applicability.展开更多
AIM To examine the association between the timing of endo-scopy and the short-term outcomes of acute variceal bleeding in cirrhotic patients.METHODS This retrospective study included 274 consecutive patients admitted ...AIM To examine the association between the timing of endo-scopy and the short-term outcomes of acute variceal bleeding in cirrhotic patients.METHODS This retrospective study included 274 consecutive patients admitted with acute esophageal variceal bleeding of two tertiary hospitals in Korea. We adjusted confounding factors using the Cox proportional hazards model and the inverse probability weighting （IPW） method. The primary outcome was the mortality of patients within 6 wk.RESULTS A total of 173 patients received urgent endoscopy （ i.e. , ≤ 12 h after admission）, and 101 patients received non-urgent endoscopy （〉 12 h after admission）. The 6-wk mortality rate was 22.5% in the urgent endoscopy group and 29.7% in the non-urgent endoscopy group, and there was no significant difference between the two groups before （P = 0.266） and after IPW （P = 0.639）. The length of hospital stay was statistically different between the urgent group and non-urgent group （P = 0.033）; however, there was no significant difference in the in-hospital mortality rate between the two groups （8.1%vs 7.9%, P = 0.960）. In multivariate analyses, timing of endoscopy was not associated with 6-wk mortality （hazard ratio, 1.297; 95% confdence interval, 0.806-2.089; P = 0.284）.CONCLUSION In cirrhotic patients with acute variceal bleeding, the timing of endoscopy may be independent of short-term mortality.展开更多
Objective:To observe the clinicopathological characteristics of gastric stump cancer(GSC)and evaluate the benefitsof radical surgery of GSC.Methods:The clinicopathological characteristics and postoperative survival ti...Objective:To observe the clinicopathological characteristics of gastric stump cancer(GSC)and evaluate the benefitsof radical surgery of GSC.Methods:The clinicopathological characteristics and postoperative survival time of 37 GSC patientswho underwent surgery were investigated retrospectively.The survival time was compared according to the type of surgicaloperation(radical resection vs palliative operation).Twenty-one cases that received radical resection were analyzed based on thepTMN stage.Survival curves were traced by using Kaplan-Meier methods.Results:Most GSC(32/37)was detected in patientswho had received Billroth Ⅱ reconstruction after partial gastrectomy for benign gastric disease.The lesser curvature side and thesuture line of anastomosis were the most frequent sites where GSC occurred(27/37).Differentiated adenocarcinoma was thedominant histopathological type(24/37).The postoperative 5-year survival rate of early stage GSC patients(n=9)was significantlyhigher than advanced stage GSC(n=12)(55.6% vs 16.5%,x_L^2=11.48,P<0.01).Five-year survival rate of 21 GSC patients withradical resection were 75%(3/4)for stage Ⅰ,60%(3/5)for stage Ⅱ,14.2%(1/7)for stage Ⅲ,and 0%(0/5)for stage Ⅳ respectively.The median survival time of 21 GSC patients who underwent radical resection was longer than those undergoing palliative op-eration(43.0 m vs 13.0 m,X_L^2=36.31,P<0.01),the median survival time of stage Ⅳ patients with radical resection was 23.8months.Conclusions:Without remote metastasis,radical resection for GSC is possible,and is an effective way to improve theprognosis of GSC.Even in stage Ⅳ GSC,radical resection can still prolong the survival time.It is necessary for the patients withbenign gastric diseases who received partial gastrectomy to carry out the endoscopy follow-up,especially in patients with BillrothⅡ reconstruction procedure at 15-20 years.展开更多
AIM： Prior Helicobacterpylori （Hpylori infection has often been underestimated. These underestimations have misled physicians attempting to determine the significance between Hpyloriand certain gastrointestinal lesi...AIM： Prior Helicobacterpylori （Hpylori infection has often been underestimated. These underestimations have misled physicians attempting to determine the significance between Hpyloriand certain gastrointestinal lesions such as intestinal metaplasia, atrophic gastritis, and gastric cancer. Our study endeavored to debit past Hppylorinfections accurately, easily, and rapidly with the newly developed irnmunoblot kit, Helico Blot 2.1. METHODS： Thirty-three patients, including 25 H pylori infected and 8 uninfected cases, were enrolled in our study. All patients received consecutive gastroendoscopic examinations and ^3C-urea breath test （UBT） tests at 6- or 12-mo intervals for up to 4 years. Serum samples were obtained from each patient at the same time. Intragastric H pylori infection was confirmed in accordance with the gold standard. Twenty-five H pylori-infected patients received triple therapies after initial bacterial confirmation, and were successful in eradicating their infections. Serially obtained sera were tested by means of Helico Blot 2.1. RESULTS： Current infection marker detected by Helico Blot 2.1 was unreliable for representing ongoing Hpylori infection. Only 35 and 37 ku antibodies of H pylorihad significant seroconversion rates 1 year after having been cured. The seroposiUve rates of 116 ku （cytotoxin-associated antigen [CagA]） and Helico Blot 2.1 were nearly 100% during 4-year follow-up period. Both CagA antigen and Helico blot 2.1 could serve as indicators of long-term H pylori infection. CONCLUSION： Helico Blot 2.1 can detect past H pylori infections for up to 4 years, and is the best method to date for detecting previous long-term H pylori infection. 2005 The WJG Press and Elsevier Inc. All rights reserved.展开更多
We explored the potential of the environment and disaster monitoring and forecasting small satellite constellations (HJ-1A/1B satellites) charge-coupled device (CCD) imagery (spatial resolution of 30 m, revisit time o...We explored the potential of the environment and disaster monitoring and forecasting small satellite constellations (HJ-1A/1B satellites) charge-coupled device (CCD) imagery (spatial resolution of 30 m, revisit time of 2 days) in the monitoring of total suspended sediment (TSS) concentrations in dynamic water bodies using Poyang Lake, the largest freshwater lake in China, as an example. Field surveys conducted during October 17-26, 2009 showed a wide range of TSS concentration (3-524 mg/L). Atmospheric correction was implemented using the Fast Line-of-sight Atmospheric Analysis of Spectral Hypercubes (FLAASH) module in ENVI with the aid of aerosol information retrieved from concurrent Terra/Moderate Resolution Imaging Spectroradiometer (MODIS) surveys, which worked well at the CCD bands with relatively high reflectance. A practical exponential retrieval algorithm was created between satellite remote sensing reflectance and in-situ measured TSS concentration. The retrieved results for the whole water area matched the in-situ data well at most stations. The retrieval errors may be related to the problem of scale matching and mixed pixel. In three selected subregions of Poyang Lake, the distribution trend of retrieved TSS was consistent with that of the field investigation. It was shown that HJ-1A/1B CCD imagery can be used to estimate TSS concentrations in Poyang Lake over synoptic scales after applying an appropriate atmospheric correction method and retrieval algorithm.展开更多
文摘近年来,健康体检越来越受到人们的重视。优序预检法（optimal order advance check method,OOACM）[1]是由我院经过近3年在健康检查工作中通过不断研究总结,形成的健康科学的管理方法,该法结合现代医学和现代管理学的理论、技术、方法和手段,能够实现对个体或群体健康状况及其影响健康的危险因素进行全面检测、评估、有效干预与连续跟踪服务的医学行为及过程。
文摘Petroleum geophysicists recognize that many parameters related to oil and gas reservoirs are predicted using seismic attribute data. However, how best to optimize the seismic attributes, predict the character of thin sandstone reservoirs, and enhance the reservoir description accuracy is an important goal for geologists and geophysicists. Based on the theory of main component analysis, we present a new optimization method, called constrained main component analysis. Modeling estimates and real application in an oilfield show that it can enhance reservoir prediction accuracy and has better applicability.
文摘AIM To examine the association between the timing of endo-scopy and the short-term outcomes of acute variceal bleeding in cirrhotic patients.METHODS This retrospective study included 274 consecutive patients admitted with acute esophageal variceal bleeding of two tertiary hospitals in Korea. We adjusted confounding factors using the Cox proportional hazards model and the inverse probability weighting （IPW） method. The primary outcome was the mortality of patients within 6 wk.RESULTS A total of 173 patients received urgent endoscopy （ i.e. , ≤ 12 h after admission）, and 101 patients received non-urgent endoscopy （〉 12 h after admission）. The 6-wk mortality rate was 22.5% in the urgent endoscopy group and 29.7% in the non-urgent endoscopy group, and there was no significant difference between the two groups before （P = 0.266） and after IPW （P = 0.639）. The length of hospital stay was statistically different between the urgent group and non-urgent group （P = 0.033）; however, there was no significant difference in the in-hospital mortality rate between the two groups （8.1%vs 7.9%, P = 0.960）. In multivariate analyses, timing of endoscopy was not associated with 6-wk mortality （hazard ratio, 1.297; 95% confdence interval, 0.806-2.089; P = 0.284）.CONCLUSION In cirrhotic patients with acute variceal bleeding, the timing of endoscopy may be independent of short-term mortality.
文摘Objective:To observe the clinicopathological characteristics of gastric stump cancer(GSC)and evaluate the benefitsof radical surgery of GSC.Methods:The clinicopathological characteristics and postoperative survival time of 37 GSC patientswho underwent surgery were investigated retrospectively.The survival time was compared according to the type of surgicaloperation(radical resection vs palliative operation).Twenty-one cases that received radical resection were analyzed based on thepTMN stage.Survival curves were traced by using Kaplan-Meier methods.Results:Most GSC(32/37)was detected in patientswho had received Billroth Ⅱ reconstruction after partial gastrectomy for benign gastric disease.The lesser curvature side and thesuture line of anastomosis were the most frequent sites where GSC occurred(27/37).Differentiated adenocarcinoma was thedominant histopathological type(24/37).The postoperative 5-year survival rate of early stage GSC patients(n=9)was significantlyhigher than advanced stage GSC(n=12)(55.6% vs 16.5%,x_L^2=11.48,P<0.01).Five-year survival rate of 21 GSC patients withradical resection were 75%(3/4)for stage Ⅰ,60%(3/5)for stage Ⅱ,14.2%(1/7)for stage Ⅲ,and 0%(0/5)for stage Ⅳ respectively.The median survival time of 21 GSC patients who underwent radical resection was longer than those undergoing palliative op-eration(43.0 m vs 13.0 m,X_L^2=36.31,P<0.01),the median survival time of stage Ⅳ patients with radical resection was 23.8months.Conclusions:Without remote metastasis,radical resection for GSC is possible,and is an effective way to improve theprognosis of GSC.Even in stage Ⅳ GSC,radical resection can still prolong the survival time.It is necessary for the patients withbenign gastric diseases who received partial gastrectomy to carry out the endoscopy follow-up,especially in patients with BillrothⅡ reconstruction procedure at 15-20 years.
基金Supported by Grants From the China American Petrochemical Co., Ltd. Foundation (CAPCO) and the National Science Council of the ROC (NSC-90-2314-B-037-044)
文摘AIM： Prior Helicobacterpylori （Hpylori infection has often been underestimated. These underestimations have misled physicians attempting to determine the significance between Hpyloriand certain gastrointestinal lesions such as intestinal metaplasia, atrophic gastritis, and gastric cancer. Our study endeavored to debit past Hppylorinfections accurately, easily, and rapidly with the newly developed irnmunoblot kit, Helico Blot 2.1. METHODS： Thirty-three patients, including 25 H pylori infected and 8 uninfected cases, were enrolled in our study. All patients received consecutive gastroendoscopic examinations and ^3C-urea breath test （UBT） tests at 6- or 12-mo intervals for up to 4 years. Serum samples were obtained from each patient at the same time. Intragastric H pylori infection was confirmed in accordance with the gold standard. Twenty-five H pylori-infected patients received triple therapies after initial bacterial confirmation, and were successful in eradicating their infections. Serially obtained sera were tested by means of Helico Blot 2.1. RESULTS： Current infection marker detected by Helico Blot 2.1 was unreliable for representing ongoing Hpylori infection. Only 35 and 37 ku antibodies of H pylorihad significant seroconversion rates 1 year after having been cured. The seroposiUve rates of 116 ku （cytotoxin-associated antigen [CagA]） and Helico Blot 2.1 were nearly 100% during 4-year follow-up period. Both CagA antigen and Helico blot 2.1 could serve as indicators of long-term H pylori infection. CONCLUSION： Helico Blot 2.1 can detect past H pylori infections for up to 4 years, and is the best method to date for detecting previous long-term H pylori infection. 2005 The WJG Press and Elsevier Inc. All rights reserved.
基金Supported by the National Basic Research Program of China(973Program)(No.2011CB707106)the National Natural Science Foundation of China(Nos.41071261,41023001,41021061,40906092,40971193,41101415)+3 种基金the Opening Foundation of Institute of Remote Sensing and Earth Sciences,Hangzhou Normal University(No.PDKF2010YG06)the Fundamental Research Funds for the Central Universities,the China Postdoctoral Science Foundation(No.20100480861)LIESMARS Special Research Funding,the Natural Science Foundation of Hubei Province,China(No.2009CDB107)the Natural Science Foundation of Zhejiang Province,China(No.Y5090143)
文摘We explored the potential of the environment and disaster monitoring and forecasting small satellite constellations (HJ-1A/1B satellites) charge-coupled device (CCD) imagery (spatial resolution of 30 m, revisit time of 2 days) in the monitoring of total suspended sediment (TSS) concentrations in dynamic water bodies using Poyang Lake, the largest freshwater lake in China, as an example. Field surveys conducted during October 17-26, 2009 showed a wide range of TSS concentration (3-524 mg/L). Atmospheric correction was implemented using the Fast Line-of-sight Atmospheric Analysis of Spectral Hypercubes (FLAASH) module in ENVI with the aid of aerosol information retrieved from concurrent Terra/Moderate Resolution Imaging Spectroradiometer (MODIS) surveys, which worked well at the CCD bands with relatively high reflectance. A practical exponential retrieval algorithm was created between satellite remote sensing reflectance and in-situ measured TSS concentration. The retrieved results for the whole water area matched the in-situ data well at most stations. The retrieval errors may be related to the problem of scale matching and mixed pixel. In three selected subregions of Poyang Lake, the distribution trend of retrieved TSS was consistent with that of the field investigation. It was shown that HJ-1A/1B CCD imagery can be used to estimate TSS concentrations in Poyang Lake over synoptic scales after applying an appropriate atmospheric correction method and retrieval algorithm.
