高速公路事故频发,而以往研究未能充分揭示交通流动态特性对事故类型与严重程度的影响。为此研究了基于动态交通流数据的高速公路事故类型与严重程度的预测方法。从高速公路门架数据中提取流量、密度、速度等交通流数据,同时考虑时间特...高速公路事故频发,而以往研究未能充分揭示交通流动态特性对事故类型与严重程度的影响。为此研究了基于动态交通流数据的高速公路事故类型与严重程度的预测方法。从高速公路门架数据中提取流量、密度、速度等交通流数据,同时考虑时间特征以及时间和空间不均匀性特征的数据,与事故数据相匹配构成全样本。建立了基于极端梯度提升树(extrem Gradient Boosting,XGBoost)算法的预测模型,预测事故是否发生、事故类型以及事故严重程度。分别考虑追尾事故和其他事故2种事故类型、有人员伤亡和仅财产损失2种事故严重程度,模型的结果表明:(1)上下游速度差大、低速、路段车流量大且频繁分流、合流条件下交通事故风险较高;(2)低速、路段车辆多且合流、分流交通量大、上下游速度差大的情况下发生追尾事故的风险更高;(3)路段车流量较少且追尾事故发生于周末或夜间可能会增大事故严重程度。将常用机器学习算法与XGBoost算法的预测效果进行对比,XGBoost事故类型预测模型与事故严重程度预测模型的ROC曲线下面积(Area Under Curve,AUC)分别达到了0.76和0.88——相比于序列Logistic、高斯朴素贝叶斯、线性SVM、随机森林以及神经网络等其他常用算法,平均分别提升了0.08和0.24。这表明基于XGBoost建立的模型具有较好的预测性能。研究结果为高速公路路段实时交通流状态预警提供了可靠手段,进而可以提升高速公路行车安全。展开更多
AIM:To analyze the prognostic value of adipokines in predicting the course,complications and fatal outcome of acute pancreatitis(AP).METHODS:We performed the search of PubMed database and the systemic analysis of the ...AIM:To analyze the prognostic value of adipokines in predicting the course,complications and fatal outcome of acute pancreatitis(AP).METHODS:We performed the search of PubMed database and the systemic analysis of the literature for both experimental and human studies on prognostic value of adipokines in AP for period 2002-2012.Only the papers that described the use of adipokines for prediction of severity and/or complications of AP were selected for further analysis.Each article had to contain information about the levels of measured adipokines,diagnosis and verification of AP,to specify presence of pancreatic necrosis,organ dysfunction and/or mortality rates.From the very beginning,study was carried out adhering to the PRISMA checklist and flowchart for systemic reviews.To assess quality of all included human studies,the Quality Assessment of Diagnostic Accuracy Studies tool was used.Because of the high heterogeneity between the studies,it was decided to refrain from the statistical processing or meta-analysis of the available data.RESULTS:Nine human and three experimental studies were included into review.In experimental studies significant differences between leptin concentrations at 24 and 48 h in control,acute edematous and acute necrotizing pancreatitis groups were found(P = 0.027 and P < 0.001).In human studies significant differences between leptin and resitin concentrations in control and acute pancreatitis groups were found.1-3 d serum adiponectin threshold of 4.5 μg/mL correctly classified the severity of 81% of patients with AP.This threshold yielded a sensitivity of 70%,specificity 85%,positive predictive value 64%,negative predictive value88%(area under curve 0.75).Resistin and visfatin concentrations differ significantly between mild and severe acute pancreatitis groups,they correlate with severity of disease,need for interventions and outcome.Both adipokines are good markers for parapancreatic necrosis and the cut-off values of 11.9 ng/mL and 1.8 ng/mL respectively predict the high ranges of radiological scores.However,the review revealed that all nine human studies with adipokines are very different in terms of methodology and objectives,so it is difficult to generalize their results.It seems that concentrations of the leptin and resistin increases significantly in patients with acute pancreatitis compared with controls.Serum levels of adiponectin,visfatin and especially resitin(positive correlation with Acute Physiology and Chronic Health Evaluation Ⅱ,Ranson and C-reactive protein) are significantly different in mild acute pancreatitis and severe acute pancreatitis patients,so,they can serve as a markers for the disease severity prediction.Resistin and visfatin can also be used for pancreatic and parapancreatic necrosis prediction,interventions needs and possible,outcome.CONCLUSION:High levels of adipokines could allow for prediction of a severe disease course and outcome even in small pancreatic lesions on computed tomography scans.展开更多
Background There is a paucity of data about the best lipid ratio predicting the severity of coronary artery disease (CAD) in patients with diabetes mellitus. We determined the relationship between five conventional ...Background There is a paucity of data about the best lipid ratio predicting the severity of coronary artery disease (CAD) in patients with diabetes mellitus. We determined the relationship between five conventional lipid ratios and the extent of coronary artery lesions in Chinese Type 2 diabetics with stable angina pectoris (SAP). Methods A prospective cohort study within 373 type 2 diabetic patients diag- nosed with stable CAD by coronary angiography was performed. All patients were classified into three groups according to the tertiles of Gensini scores (GS, low group 〈 8 points n = 143; intermediate group 8-28 points, n = 109; high group 〉 28 points, n = 121). Association between the ratios of apolipoprotein (apo) B and apoA-1, total cholesterol and high density lipoprotein cholesterol (TC/HDL-C), triglycerides and HDL-C (TG/HDL-C), low density lipoprotein cholesterol and HDL-C (LDL-C/HDL-C), Non-HDL-C/HDL-C and GS were evaluated using the receivers operating characteristic (ROC) curves and multivariate logistic regression models. Results The ratio of apoB/apoA-1, TC/HDL-C, LDL-C/HDL-C, and Non-HDL-C/HDL-C were correlated with Gensini scores. Area under the ROC curves for predicting high Gensini scores in the ratios of apoB/apoA-1, TC/HDL-C, LDL-C/HDL-C and Non-HDL-C/HDL-C were 0.62, 0.60, 0.59 and 0.60, respec- tively (P 〈 0.005 for all). According to multivariate logistic regression analysis after adjusted with demographic characteristic and other lipid parameters, the ratio of apoB/apoA-1 is qualified as an independent discriminator for the severity of CAD. However, after fiu-ther adjusting different baseline variables, such as left ventricular ejective fraction, hemoglobin Alc, leukocytes count and serum creatinine, none of the above lipid ratios remained. Conclusions Compared with other lipid parameters, the ratio of apoB/apoA-1 appears to be more significantly correlated with the extent of coronary artery lesions in Chinese diabetics, but it was not an independent predictor in these settings.展开更多
It has been emphasized that the assessment of residual liver function is of paramount importance to determine the following: severity of acute or chronic liver diseases independent of etiology; long-term prognosis; s...It has been emphasized that the assessment of residual liver function is of paramount importance to determine the following: severity of acute or chronic liver diseases independent of etiology; long-term prognosis; step-bystep disease progression; surgical risk; and efficacy of antiviral treatment. The most frequently used tools are the galactose elimination capacity to asses hepatocyte cytosol activity, plasma clearance of indocyanine green to assess excretory function, and antipyrine clearance to estimate microsomal activity. However, a widely accepted liver test (not necessarily a laboratory one) to assess quantitative functional hepatic reserve still needs to be established, although there have been various proposals. Furthermore, who are the operators that should order these tests? Advances in analytic methods are expected to allow quantitative liver function tests to be used in clinical practice.展开更多
The purpose of the present research was to investigate the predictors to Chinese college students seeking psychological help from professionals. By surveying 1,408 Chinese college students at five universities in Chin...The purpose of the present research was to investigate the predictors to Chinese college students seeking psychological help from professionals. By surveying 1,408 Chinese college students at five universities in China's Mainland, the results showed that among the factors examined, problem severity and help-seeking attitudes directly predicted help-seeking intention, while gender and subjective norms had a significant effect on college students' professional psychological help-seeking intention through help-seeking attitudes. Overall, the model explained 25% and 38.0% (for half-1 and half-2 data sets, respectively) of the variances of help-seeking intention. The results indicated that mainland Chinese college students rationally knew that they should choose to seek such professional help when the problem got severer enough, although they were emotionally reluctant to seek professional psychological help due to negative subjective norms around them. The implications and limitations were discussed.展开更多
Network measures are useful for predicting fault-prone modules. However, existing work has not distinguished faults according to their severity. In practice, high severity faults cause serious problems and require fur...Network measures are useful for predicting fault-prone modules. However, existing work has not distinguished faults according to their severity. In practice, high severity faults cause serious problems and require further attention. In this study, we explored the utility of network measures in high severity faultproneness prediction. We constructed software source code networks for four open-source projects by extracting the dependencies between modules. We then used univariate logistic regression to investigate the associations between each network measure and fault-proneness at a high severity level. We built multivariate prediction models to examine their explanatory ability for fault-proneness, as well as evaluated their predictive effectiveness compared to code metrics under forward-release and cross-project predictions. The results revealed the following:(1) most network measures are significantly related to high severity fault-proneness;(2) network measures generally have comparable explanatory abilities and predictive powers to those of code metrics; and(3) network measures are very unstable for cross-project predictions. These results indicate that network measures are of practical value in high severity fault-proneness prediction.展开更多
文摘高速公路事故频发,而以往研究未能充分揭示交通流动态特性对事故类型与严重程度的影响。为此研究了基于动态交通流数据的高速公路事故类型与严重程度的预测方法。从高速公路门架数据中提取流量、密度、速度等交通流数据,同时考虑时间特征以及时间和空间不均匀性特征的数据,与事故数据相匹配构成全样本。建立了基于极端梯度提升树(extrem Gradient Boosting,XGBoost)算法的预测模型,预测事故是否发生、事故类型以及事故严重程度。分别考虑追尾事故和其他事故2种事故类型、有人员伤亡和仅财产损失2种事故严重程度,模型的结果表明:(1)上下游速度差大、低速、路段车流量大且频繁分流、合流条件下交通事故风险较高;(2)低速、路段车辆多且合流、分流交通量大、上下游速度差大的情况下发生追尾事故的风险更高;(3)路段车流量较少且追尾事故发生于周末或夜间可能会增大事故严重程度。将常用机器学习算法与XGBoost算法的预测效果进行对比,XGBoost事故类型预测模型与事故严重程度预测模型的ROC曲线下面积(Area Under Curve,AUC)分别达到了0.76和0.88——相比于序列Logistic、高斯朴素贝叶斯、线性SVM、随机森林以及神经网络等其他常用算法,平均分别提升了0.08和0.24。这表明基于XGBoost建立的模型具有较好的预测性能。研究结果为高速公路路段实时交通流状态预警提供了可靠手段,进而可以提升高速公路行车安全。
文摘AIM:To analyze the prognostic value of adipokines in predicting the course,complications and fatal outcome of acute pancreatitis(AP).METHODS:We performed the search of PubMed database and the systemic analysis of the literature for both experimental and human studies on prognostic value of adipokines in AP for period 2002-2012.Only the papers that described the use of adipokines for prediction of severity and/or complications of AP were selected for further analysis.Each article had to contain information about the levels of measured adipokines,diagnosis and verification of AP,to specify presence of pancreatic necrosis,organ dysfunction and/or mortality rates.From the very beginning,study was carried out adhering to the PRISMA checklist and flowchart for systemic reviews.To assess quality of all included human studies,the Quality Assessment of Diagnostic Accuracy Studies tool was used.Because of the high heterogeneity between the studies,it was decided to refrain from the statistical processing or meta-analysis of the available data.RESULTS:Nine human and three experimental studies were included into review.In experimental studies significant differences between leptin concentrations at 24 and 48 h in control,acute edematous and acute necrotizing pancreatitis groups were found(P = 0.027 and P < 0.001).In human studies significant differences between leptin and resitin concentrations in control and acute pancreatitis groups were found.1-3 d serum adiponectin threshold of 4.5 μg/mL correctly classified the severity of 81% of patients with AP.This threshold yielded a sensitivity of 70%,specificity 85%,positive predictive value 64%,negative predictive value88%(area under curve 0.75).Resistin and visfatin concentrations differ significantly between mild and severe acute pancreatitis groups,they correlate with severity of disease,need for interventions and outcome.Both adipokines are good markers for parapancreatic necrosis and the cut-off values of 11.9 ng/mL and 1.8 ng/mL respectively predict the high ranges of radiological scores.However,the review revealed that all nine human studies with adipokines are very different in terms of methodology and objectives,so it is difficult to generalize their results.It seems that concentrations of the leptin and resistin increases significantly in patients with acute pancreatitis compared with controls.Serum levels of adiponectin,visfatin and especially resitin(positive correlation with Acute Physiology and Chronic Health Evaluation Ⅱ,Ranson and C-reactive protein) are significantly different in mild acute pancreatitis and severe acute pancreatitis patients,so,they can serve as a markers for the disease severity prediction.Resistin and visfatin can also be used for pancreatic and parapancreatic necrosis prediction,interventions needs and possible,outcome.CONCLUSION:High levels of adipokines could allow for prediction of a severe disease course and outcome even in small pancreatic lesions on computed tomography scans.
文摘Background There is a paucity of data about the best lipid ratio predicting the severity of coronary artery disease (CAD) in patients with diabetes mellitus. We determined the relationship between five conventional lipid ratios and the extent of coronary artery lesions in Chinese Type 2 diabetics with stable angina pectoris (SAP). Methods A prospective cohort study within 373 type 2 diabetic patients diag- nosed with stable CAD by coronary angiography was performed. All patients were classified into three groups according to the tertiles of Gensini scores (GS, low group 〈 8 points n = 143; intermediate group 8-28 points, n = 109; high group 〉 28 points, n = 121). Association between the ratios of apolipoprotein (apo) B and apoA-1, total cholesterol and high density lipoprotein cholesterol (TC/HDL-C), triglycerides and HDL-C (TG/HDL-C), low density lipoprotein cholesterol and HDL-C (LDL-C/HDL-C), Non-HDL-C/HDL-C and GS were evaluated using the receivers operating characteristic (ROC) curves and multivariate logistic regression models. Results The ratio of apoB/apoA-1, TC/HDL-C, LDL-C/HDL-C, and Non-HDL-C/HDL-C were correlated with Gensini scores. Area under the ROC curves for predicting high Gensini scores in the ratios of apoB/apoA-1, TC/HDL-C, LDL-C/HDL-C and Non-HDL-C/HDL-C were 0.62, 0.60, 0.59 and 0.60, respec- tively (P 〈 0.005 for all). According to multivariate logistic regression analysis after adjusted with demographic characteristic and other lipid parameters, the ratio of apoB/apoA-1 is qualified as an independent discriminator for the severity of CAD. However, after fiu-ther adjusting different baseline variables, such as left ventricular ejective fraction, hemoglobin Alc, leukocytes count and serum creatinine, none of the above lipid ratios remained. Conclusions Compared with other lipid parameters, the ratio of apoB/apoA-1 appears to be more significantly correlated with the extent of coronary artery lesions in Chinese diabetics, but it was not an independent predictor in these settings.
文摘It has been emphasized that the assessment of residual liver function is of paramount importance to determine the following: severity of acute or chronic liver diseases independent of etiology; long-term prognosis; step-bystep disease progression; surgical risk; and efficacy of antiviral treatment. The most frequently used tools are the galactose elimination capacity to asses hepatocyte cytosol activity, plasma clearance of indocyanine green to assess excretory function, and antipyrine clearance to estimate microsomal activity. However, a widely accepted liver test (not necessarily a laboratory one) to assess quantitative functional hepatic reserve still needs to be established, although there have been various proposals. Furthermore, who are the operators that should order these tests? Advances in analytic methods are expected to allow quantitative liver function tests to be used in clinical practice.
文摘The purpose of the present research was to investigate the predictors to Chinese college students seeking psychological help from professionals. By surveying 1,408 Chinese college students at five universities in China's Mainland, the results showed that among the factors examined, problem severity and help-seeking attitudes directly predicted help-seeking intention, while gender and subjective norms had a significant effect on college students' professional psychological help-seeking intention through help-seeking attitudes. Overall, the model explained 25% and 38.0% (for half-1 and half-2 data sets, respectively) of the variances of help-seeking intention. The results indicated that mainland Chinese college students rationally knew that they should choose to seek such professional help when the problem got severer enough, although they were emotionally reluctant to seek professional psychological help due to negative subjective norms around them. The implications and limitations were discussed.
基金supported by National Natural Science Foundation of China (Grant Nos. 61472175, 61472178, 61272082, 61272080, 91418202)Natural Science Foundation of Jiangsu Province (Grant No. BK20130014)Natural Science Foundation of Colleges in Jiangsu Province (Grant No. 13KJB520018)
文摘Network measures are useful for predicting fault-prone modules. However, existing work has not distinguished faults according to their severity. In practice, high severity faults cause serious problems and require further attention. In this study, we explored the utility of network measures in high severity faultproneness prediction. We constructed software source code networks for four open-source projects by extracting the dependencies between modules. We then used univariate logistic regression to investigate the associations between each network measure and fault-proneness at a high severity level. We built multivariate prediction models to examine their explanatory ability for fault-proneness, as well as evaluated their predictive effectiveness compared to code metrics under forward-release and cross-project predictions. The results revealed the following:(1) most network measures are significantly related to high severity fault-proneness;(2) network measures generally have comparable explanatory abilities and predictive powers to those of code metrics; and(3) network measures are very unstable for cross-project predictions. These results indicate that network measures are of practical value in high severity fault-proneness prediction.